MOUSE:FGF4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fgf4 (synonyms: Fgf-4, Kfgf)
Protein Name(s)	Fibroblast growth factor 4 FGF-4 Heparin-binding growth factor 4 HBGF-4 K-fibroblast growth factor
External Links
UniProt	P11403
EMBL	X14849 M30642 AK082814 AC149593 AC161763 CH466531 BC104312 BC104313
CCDS	CCDS22052.1
PIR	S04741
RefSeq	NP_034332.2
UniGene	Mm.4956
ProteinModelPortal	P11403
SMR	P11403
BioGrid	199649
STRING	10090.ENSMUSP00000056752
iPTMnet	P11403
PhosphoSitePlus	P11403
PaxDb	P11403
PeptideAtlas	P11403
PRIDE	P11403
Ensembl	ENSMUST00000060336
GeneID	14175
KEGG	mmu:14175
UCSC	uc009kqq.1
CTD	2249
MGI	MGI:95518
eggNOG	KOG3885 ENOG4111IPH
GeneTree	ENSGT00760000118859
HOGENOM	HOG000236341
HOVERGEN	HBG007580
InParanoid	P11403
KO	K04358
OMA	YNAYESH
OrthoDB	EOG091G0NAY
TreeFam	TF317805
Reactome	R-MMU-109704 R-MMU-1257604 R-MMU-190322 R-MMU-190372 R-MMU-190373 R-MMU-190375 R-MMU-5654219 R-MMU-5654221 R-MMU-5654227 R-MMU-5654228 R-MMU-5654687 R-MMU-5654688 R-MMU-5654689 R-MMU-5654693 R-MMU-5654695 R-MMU-5654699 R-MMU-5654700 R-MMU-5654704 R-MMU-5654706 R-MMU-5654710 R-MMU-5654712 R-MMU-5654719 R-MMU-5654720 R-MMU-5654726 R-MMU-5654727 R-MMU-5654732 R-MMU-5654733 R-MMU-5658623 R-MMU-5673001 R-MMU-6811558
PRO	PR:P11403
Proteomes	UP000000589
Bgee	ENSMUSG00000050917
CleanEx	MM_FGF4
ExpressionAtlas	P11403
Genevisible	P11403
GO	GO:0005576 GO:0005104 GO:0008083 GO:0060561 GO:0001502 GO:1990830 GO:0060591 GO:0060363 GO:0035116 GO:0030326 GO:0008543 GO:0010463 GO:0043066 GO:0042475 GO:0051781 GO:0008284 GO:0070374 GO:0010628 GO:0001934 GO:0045944 GO:2000544 GO:0010468 GO:0019827
CDD	cd00058
InterPro	IPR028239 IPR002209 IPR008996
PANTHER	PTHR11486 PTHR11486:SF31
Pfam	PF00167
PRINTS	PR00263
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1905437	positive regulation of histone H3-K4 trimethylation	PMID:26691508^[1]	ECO:0000314			P		Fig. 2 (top panel) shows that in mice, levels of H3K4 trimethylation associated with the Fgf4 promoter increase during reprogramming.	complete CACAO 13363
acts_upstream_of_or_within	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060591	chondroblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060561	apoptotic process involved in morphogenesis	PMID:15649466^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96970	P	occurs_in:(EMAPA:17938) occurs_in:(CL:0000066)\|occurs_in:(EMAPA:17917) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060363	cranial suture morphogenesis	PMID:9477322^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8898217^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97168	P	has_regulation_target:(MGI:MGI:1349162)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9477322^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:16245339^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99604	P	regulates_o_occurs_in:(EMAPA:16781) regulates_o_occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:12502739^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035116	embryonic hindlimb morphogenesis	PMID:16245339^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99604	P	results_in_development_of:(EMAPA:16779)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:15328019^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99604	P	has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:15328412^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97359	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:9244299^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97493)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:19289495^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010463	mesenchymal cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:16245339^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:17951031^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:19289495^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001502	cartilage condensation	PMID:8565825^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98726	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08620 ensembl:ENSP00000168712	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08620 ensembl:ENSP00000168712	P		Seeded From UniProt	complete
involved_in	GO:0060591	chondroblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08620 ensembl:ENSP00000168712	P		Seeded From UniProt	complete
involved_in	GO:0010463	mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08620 ensembl:ENSP00000168712	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08620 ensembl:ENSP00000168712	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08620 ensembl:ENSP00000168712	P		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028239	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028239	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028239	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ Sasaki, T et al. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev. Biol. 278 130-43 PubMed GONUTS page
↑ ^4.0 ^4.1 Kim, HJ et al. (1998) FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 125 1241-51 PubMed GONUTS page
↑ Chen, Y et al. (1996) Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 122 3035-44 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lancman, JJ et al. (2005) Analysis of the regulation of lin-41 during chick and mouse limb development. Dev. Dyn. 234 948-60 PubMed GONUTS page
↑ Kratochwil, K et al. (2002) FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev. 16 3173-85 PubMed GONUTS page
↑ Boulet, AM et al. (2004) The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev. Biol. 273 361-72 PubMed GONUTS page
↑ Zhang, Z et al. (2004) Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Proc. Natl. Acad. Sci. U.S.A. 101 12946-51 PubMed GONUTS page
↑ Neubüser, A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90 247-55 PubMed GONUTS page
↑ ^11.0 ^11.1 Abell, AN et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol. Cell. Biol. 29 2748-61 PubMed GONUTS page
↑ Kettunen, P et al. () Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech. Dev. 124 868-83 PubMed GONUTS page
↑ Grass, S et al. (1996) Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development 122 141-50 PubMed GONUTS page

[PMID:26691508-1] Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page

[PMID:20439489-2] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:15649466-3] Sasaki, T et al. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev. Biol. 278 130-43 PubMed GONUTS page

[PMID:9477322-4] 4.0 ^4.1 Kim, HJ et al. (1998) FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 125 1241-51 PubMed GONUTS page

[PMID:8898217-5] Chen, Y et al. (1996) Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 122 3035-44 PubMed GONUTS page

[PMID:16245339-6] 6.0 ^6.1 ^6.2 Lancman, JJ et al. (2005) Analysis of the regulation of lin-41 during chick and mouse limb development. Dev. Dyn. 234 948-60 PubMed GONUTS page

[PMID:12502739-7] Kratochwil, K et al. (2002) FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev. 16 3173-85 PubMed GONUTS page

[PMID:15328019-8] Boulet, AM et al. (2004) The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev. Biol. 273 361-72 PubMed GONUTS page

[PMID:15328412-9] Zhang, Z et al. (2004) Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Proc. Natl. Acad. Sci. U.S.A. 101 12946-51 PubMed GONUTS page

[PMID:9244299-10] Neubüser, A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90 247-55 PubMed GONUTS page

[PMID:19289495-11] 11.0 ^11.1 Abell, AN et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol. Cell. Biol. 29 2748-61 PubMed GONUTS page

[PMID:17951031-12] Kettunen, P et al. () Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech. Dev. 124 868-83 PubMed GONUTS page

[PMID:8565825-13] Grass, S et al. (1996) Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development 122 141-50 PubMed GONUTS page

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MOUSE:FGF4

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References

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