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MOUSE:FBX11

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Fbxo11
Protein Name(s) F-box only protein 11
External Links
UniProt Q7TPD1
EMBL AC087233
AC154673
BC049946
BC055343
BC117884
BC117885
BC128479
CCDS CCDS37717.1
RefSeq NP_001074503.1
XP_006524267.1
UniGene Mm.386857
ProteinModelPortal Q7TPD1
DIP DIP-59433N
PhosphoSite Q7TPD1
MaxQB Q7TPD1
PaxDb Q7TPD1
PRIDE Q7TPD1
Ensembl ENSMUST00000005504
GeneID 225055
KEGG mmu:225055
CTD 80204
MGI MGI:2147134
eggNOG NOG12793
GeneTree ENSGT00530000063425
HOGENOM HOG000020584
HOVERGEN HBG051565
InParanoid Q7TPD1
KO K10297
OMA VPHHKHY
OrthoDB EOG73803Z
TreeFam TF313602
UniPathway UPA00143
ChiTaRS Fbxo11
NextBio 377524
PRO PR:Q7TPD1
Proteomes UP000000589
Bgee E9QP06
CleanEx MM_FBXO11
ExpressionAtlas Q7TPD1
Genevestigator Q7TPD1
GO GO:0005694
GO:0005737
GO:0005730
GO:0016274
GO:0004842
GO:0008270
GO:0007605
Gene3D 2.160.20.10
InterPro IPR006633
IPR001810
IPR029799
IPR022441
IPR006626
IPR012334
IPR011050
IPR003126
PANTHER PTHR22990:SF12
Pfam PF12937
PF02207
SMART SM00722
SM00256
SM00710
SUPFAM SSF51126
SSF81383
TIGRFAMs TIGR03804
PROSITE PS50181
PS51157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004842

ubiquitin-protein ligase activity

PMID:22113614[1]

ECO:0000315

F

Figure 1 show that FBOX proteins were flagged and immunoblotting indicated that FBXO11 is directly involved in ubiquitin-mediated degradation of BCL6

complete
CACAO 5201

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:22113614[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

PMID:17035249[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016274

protein-arginine N-methyltransferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q86XK2

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007605

sensory perception of sound

PMID:10932191[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861993

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006464

cellular protein modification process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q86XK2

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q86XK2

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q86XK2

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q86XK2

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q86XK2

C

Seeded From UniProt

complete

involved_in

GO:0035246

peptidyl-arginine N-methylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016274

P

Seeded From UniProt

complete

involved_in

GO:0035246

peptidyl-arginine N-methylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016274

P

Seeded From UniProt

complete

enables

GO:0016274

protein-arginine N-methyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q86XK2
ensembl:ENSP00000384823

F

Seeded From UniProt

complete

involved_in

GO:0006464

cellular protein modification process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q86XK2
ensembl:ENSP00000384823

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q86XK2
ensembl:ENSP00000384823

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q86XK2
ensembl:ENSP00000384823

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q86XK2
ensembl:ENSP00000384823

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q86XK2
ensembl:ENSP00000384823

C

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029799

C

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003126

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029799

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Duan, S et al. (2012) FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature 481 90-3 PubMed GONUTS page
  2. Hardisty-Hughes, RE et al. (2006) A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse. Hum. Mol. Genet. 15 3273-9 PubMed GONUTS page
  3. Nolan, PM et al. (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat. Genet. 25 440-3 PubMed GONUTS page