MOUSE:F262

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pfkfb2
Protein Name(s)	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6PF-2-K/Fru-2,6-P2ase 2 PFK/FBPase 2 6PF-2-K/Fru-2,6-P2ase heart-type isozyme 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
External Links
UniProt	P70265
EMBL	X98847 BC018418
PIR	S74242
RefSeq	NP_032851.2
UniGene	Mm.249861
ProteinModelPortal	P70265
SMR	P70265
BioGrid	202123
IntAct	P70265
STRING	10090.ENSMUSP00000066426
PhosphoSite	P70265
MaxQB	P70265
PaxDb	P70265
PRIDE	P70265
DNASU	18640
GeneID	18640
KEGG	mmu:18640
CTD	5208
MGI	MGI:107815
eggNOG	COG0406
HOGENOM	HOG000181112
HOVERGEN	HBG005628
InParanoid	P70265
KO	K01103
PhylomeDB	P70265
BRENDA	3.1.3.46
NextBio	294622
PRO	PR:P70265
Proteomes	UP000000589
Genevestigator	P70265
GO	GO:0003873 GO:0005524 GO:0004331 GO:0046835 GO:0006003 GO:0006000 GO:0006096
Gene3D	3.40.50.1240 3.40.50.300
InterPro	IPR003094 IPR013079 IPR016260 IPR013078 IPR029033 IPR027417 IPR001345
PANTHER	PTHR10606
Pfam	PF01591 PF00300
PIRSF	PIRSF000709
PRINTS	PR00991
SMART	SM00855
SUPFAM	SSF52540 SSF53254
PROSITE	PS00175

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	PMID:18039179	ECO:0000314			F		Figure 3.	complete CACAO 6314
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	PMID:18039179	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60825	P		Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60825	F		Seeded From UniProt	complete
involved_in	GO:0006003	fructose 2,6-bisphosphate metabolic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743282 RGD:619776 SGD:S000001369 SGD:S000005496 TAIR:locus:2007367 UniProtKB:P16118	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743282 TAIR:locus:2007367	C		Seeded From UniProt	complete
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107815 PANTHER:PTN000064403 RGD:3307 RGD:3309 RGD:3310 SGD:S000003691 TAIR:locus:2007367 UniProtKB:P16118	F		Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743282 RGD:3307 RGD:3310 SGD:S000001369 UniProtKB:O60825 UniProtKB:P16118 UniProtKB:Q16875 UniProtKB:Q16877	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033133	positive regulation of glucokinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60825	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009749	response to glucose	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006096	glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60825	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006090	pyruvate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006089	lactate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006007	glucose catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60825	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60825	C		Seeded From UniProt	complete
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3309	F		Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60825	F		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004331	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004331	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004331	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004331	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003873	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003873	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003873	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003873	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003873	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001345 InterPro:IPR003094	F		Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013079	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003094 InterPro:IPR013079	F		Seeded From UniProt	complete
involved_in	GO:0006000	fructose metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013079	P		Seeded From UniProt	complete
involved_in	GO:0006003	fructose 2,6-bisphosphate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003094	P		Seeded From UniProt	complete
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.46	F		Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.105	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
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References

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