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MOUSE:EFNA1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Efna1 (synonyms: Epgl1, Epl1, Lerk1) | |
Protein Name(s) | Ephrin-A1
EPH-related receptor tyrosine kinase ligand 1 LERK-1 Immediate early response protein B61 Ephrin-A1, secreted form | |
External Links | ||
UniProt | P52793 | |
EMBL | D38146 U26188 U90662 BC002046 | |
CCDS | CCDS17501.1 | |
RefSeq | NP_034237.3 | |
UniGene | Mm.15675 | |
ProteinModelPortal | P52793 | |
SMR | P52793 | |
BioGrid | 199389 | |
IntAct | P52793 | |
STRING | 10090.ENSMUSP00000029566 | |
PhosphoSite | P52793 | |
PaxDb | P52793 | |
PRIDE | P52793 | |
Ensembl | ENSMUST00000029566 | |
GeneID | 13636 | |
KEGG | mmu:13636 | |
UCSC | uc008pyo.2 | |
CTD | 1942 | |
MGI | MGI:103236 | |
eggNOG | NOG296825 | |
GeneTree | ENSGT00390000015107 | |
HOGENOM | HOG000234373 | |
HOVERGEN | HBG051447 | |
InParanoid | P52793 | |
KO | K05462 | |
OMA | PIHHQED | |
OrthoDB | EOG70W3FD | |
PhylomeDB | P52793 | |
Reactome | REACT_243590 REACT_243939 REACT_258158 | |
NextBio | 284320 | |
PRO | PR:P52793 | |
Proteomes | UP000000589 | |
Bgee | P52793 | |
CleanEx | MM_EFNA1 | |
ExpressionAtlas | P52793 | |
Genevestigator | P52793 | |
GO | GO:0046658 GO:0070062 GO:0046875 GO:0000187 GO:0001525 GO:0003180 GO:0007411 GO:0016477 GO:0003199 GO:0048013 GO:0003183 GO:0061002 GO:0010719 GO:0000122 GO:0030182 GO:0014028 GO:0050731 GO:0045765 GO:0050770 GO:0043535 GO:0033628 GO:0050730 GO:0034446 | |
Gene3D | 2.60.40.420 | |
InterPro | IPR008972 IPR001799 IPR019765 | |
PANTHER | PTHR11304 | |
Pfam | PF00812 | |
PRINTS | PR01347 | |
ProDom | PD002533 | |
SUPFAM | SSF49503 | |
PROSITE | PS01299 PS51551 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000314 |
P |
Figure 3-results indicate that both Vav2 and Vav3 are activated by EphA receptor forward signaling to promote Rac1 GTPase activity. |
complete | |||||
involved_in |
GO:0010719 |
negative regulation of epithelial to mesenchymal transition |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003199 |
endocardial cushion to mesenchymal transition involved in heart valve formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003183 |
mitral valve morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003180 |
aortic valve morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061002 |
negative regulation of dendritic spine morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050730 |
regulation of peptidyl-tyrosine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0046658 |
anchored component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045765 |
regulation of angiogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043535 |
regulation of blood vessel endothelial cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:102707 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046875 |
ephrin receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040324 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0046658 |
anchored component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103236 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007411 |
axon guidance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040324 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:105097 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1903051 |
negative regulation of proteolysis involved in cellular protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902961 |
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902004 |
positive regulation of amyloid-beta formation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070244 |
negative regulation of thymocyte apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0061098 |
positive regulation of protein tyrosine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050821 |
protein stabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050770 |
regulation of axonogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046875 |
ephrin receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043409 |
negative regulation of MAPK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034446 |
substrate adhesion-dependent cell spreading |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033628 |
regulation of cell adhesion mediated by integrin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030182 |
neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0016477 |
cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0014028 |
notochord formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:95278 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903051 |
negative regulation of proteolysis involved in cellular protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902961 |
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902004 |
positive regulation of amyloid-beta formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061098 |
positive regulation of protein tyrosine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046875 |
ephrin receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034446 |
substrate adhesion-dependent cell spreading |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033628 |
regulation of cell adhesion mediated by integrin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016477 |
cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20827 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046875 |
ephrin receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031225 |
anchored component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Hunter, SG et al. (2006) Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol. Cell. Biol. 26 4830-42 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Frieden, LA et al. (2010) Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1. Dev. Dyn. 239 3226-34 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Fu, WY et al. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat. Neurosci. 10 67-76 PubMed GONUTS page
- ↑ Wykosky, J et al. (2008) Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene 27 7260-73 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Freywald, A et al. (2006) EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes. J. Immunol. 176 4066-74 PubMed GONUTS page
- ↑ 7.0 7.1 Tanaka, M et al. (2004) Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 23 1075-88 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Aoki, M et al. (2004) EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway. J. Biol. Chem. 279 32643-50 PubMed GONUTS page
- ↑ Naruse-Nakajima, C et al. (2001) Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1. Mech. Dev. 102 95-105 PubMed GONUTS page
e
g
m
n
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0070244 ! negative regulation of thymocyte apoptotic process
- GO:0043409 ! negative regulation of MAPK cascade
- GO:1903051 ! negative regulation of proteolysis involved in protein catabolic process
- GO:0061002 ! negative regulation of dendritic spine morphogenesis
- GO:0010719 ! negative regulation of epithelial to mesenchymal transition
- GO:0030182 ! neuron differentiation
- GO:0014028 ! notochord formation
o
p
- GO:0005886 ! plasma membrane
- GO:1902961 ! positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- GO:1902004 ! positive regulation of amyloid-beta formation
- GO:0061098 ! positive regulation of protein tyrosine kinase activity
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0050821 ! protein stabilization
r