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MOUSE:EFNA1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Efna1 (synonyms: Epgl1, Epl1, Lerk1)
Protein Name(s) Ephrin-A1

EPH-related receptor tyrosine kinase ligand 1 LERK-1 Immediate early response protein B61 Ephrin-A1, secreted form

External Links
UniProt P52793
EMBL D38146
U26188
U90662
BC002046
CCDS CCDS17501.1
RefSeq NP_034237.3
UniGene Mm.15675
ProteinModelPortal P52793
SMR P52793
BioGrid 199389
IntAct P52793
STRING 10090.ENSMUSP00000029566
PhosphoSite P52793
PaxDb P52793
PRIDE P52793
Ensembl ENSMUST00000029566
GeneID 13636
KEGG mmu:13636
UCSC uc008pyo.2
CTD 1942
MGI MGI:103236
eggNOG NOG296825
GeneTree ENSGT00390000015107
HOGENOM HOG000234373
HOVERGEN HBG051447
InParanoid P52793
KO K05462
OMA PIHHQED
OrthoDB EOG70W3FD
PhylomeDB P52793
Reactome REACT_243590
REACT_243939
REACT_258158
NextBio 284320
PRO PR:P52793
Proteomes UP000000589
Bgee P52793
CleanEx MM_EFNA1
ExpressionAtlas P52793
Genevestigator P52793
GO GO:0046658
GO:0070062
GO:0046875
GO:0000187
GO:0001525
GO:0003180
GO:0007411
GO:0016477
GO:0003199
GO:0048013
GO:0003183
GO:0061002
GO:0010719
GO:0000122
GO:0030182
GO:0014028
GO:0050731
GO:0045765
GO:0050770
GO:0043535
GO:0033628
GO:0050730
GO:0034446
Gene3D 2.60.40.420
InterPro IPR008972
IPR001799
IPR019765
PANTHER PTHR11304
Pfam PF00812
PRINTS PR01347
ProDom PD002533
SUPFAM SSF49503
PROSITE PS01299
PS51551

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0048013

ephrin receptor signaling pathway

PMID:16782872[1]

ECO:0000314

P

Figure 3-results indicate that both Vav2 and Vav3 are activated by EphA receptor forward signaling to promote Rac1 GTPase activity.

complete
CACAO 6553

involved_in

GO:0010719

negative regulation of epithelial to mesenchymal transition

PMID:20960543[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003199

endocardial cushion to mesenchymal transition involved in heart valve formation

PMID:20960543[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003183

mitral valve morphogenesis

PMID:20960543[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

PMID:20960543[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:20960543[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061002

negative regulation of dendritic spine morphogenesis

PMID:17143272[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

PMID:17143272[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

PMID:17143272[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0046658

anchored component of plasma membrane

PMID:18794797[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045765

regulation of angiogenesis

PMID:16782872[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043535

regulation of blood vessel endothelial cell migration

PMID:16782872[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102707
MGI:MGI:103236
MGI:MGI:106644
MGI:MGI:107444
PANTHER:PTN000885159
UniProtKB:P20827
UniProtKB:P52797
UniProtKB:P52799
UniProtKB:P52803
UniProtKB:Q15768
WB:WBGene00006869

P

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040324
MGI:MGI:102707
MGI:MGI:102708
MGI:MGI:106644
MGI:MGI:107444
PANTHER:PTN000885159
RGD:620391
UniProtKB:P20827
UniProtKB:P52797
UniProtKB:P52798
UniProtKB:P52799
UniProtKB:P52803
UniProtKB:Q15768
WB:WBGene00006869

F

Seeded From UniProt

complete

part_of

GO:0046658

anchored component of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103236
PANTHER:PTN000139181

C

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040324
MGI:MGI:102708
MGI:MGI:107444
MGI:MGI:109196
PANTHER:PTN000885159
RGD:620389

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:105097
MGI:MGI:107444
PANTHER:PTN000885159
UniProtKB:P52799
UniProtKB:P98172
UniProtKB:Q15768

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903051

negative regulation of proteolysis involved in cellular protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902961

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070244

negative regulation of thymocyte apoptotic process

PMID:16547242[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061098

positive regulation of protein tyrosine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050821

protein stabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050770

regulation of axonogenesis

PMID:14988728[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048013

ephrin receptor signaling pathway

PMID:15145949[8]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16895)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048013

ephrin receptor signaling pathway

PMID:14988728[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048013

ephrin receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043410

positive regulation of MAPK cascade

PMID:15145949[8]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16895)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043409

negative regulation of MAPK cascade

PMID:16547242[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034446

substrate adhesion-dependent cell spreading

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033628

regulation of cell adhesion mediated by integrin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030182

neuron differentiation

PMID:15145949[8]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16895)
  • results_in_acquisition_of_features_of:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016477

cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014028

notochord formation

PMID:11287184[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95278

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P20827

P

Seeded From UniProt

complete

involved_in

GO:1903051

negative regulation of proteolysis involved in cellular protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:1902961

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:1902004

positive regulation of amyloid-beta formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:0061098

positive regulation of protein tyrosine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

F

Seeded From UniProt

complete

involved_in

GO:0034446

substrate adhesion-dependent cell spreading

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:0033628

regulation of cell adhesion mediated by integrin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P20827
ensembl:ENSP00000357392

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001799
InterPro:IPR019765

C

Seeded From UniProt

complete

enables

GO:0046875

ephrin receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034252

F

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034252

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0031225

anchored component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0336

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Hunter, SG et al. (2006) Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol. Cell. Biol. 26 4830-42 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Frieden, LA et al. (2010) Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1. Dev. Dyn. 239 3226-34 PubMed GONUTS page
  3. 3.0 3.1 3.2 Fu, WY et al. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat. Neurosci. 10 67-76 PubMed GONUTS page
  4. Wykosky, J et al. (2008) Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene 27 7260-73 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. 6.0 6.1 Freywald, A et al. (2006) EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes. J. Immunol. 176 4066-74 PubMed GONUTS page
  7. 7.0 7.1 Tanaka, M et al. (2004) Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 23 1075-88 PubMed GONUTS page
  8. 8.0 8.1 8.2 Aoki, M et al. (2004) EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway. J. Biol. Chem. 279 32643-50 PubMed GONUTS page
  9. Naruse-Nakajima, C et al. (2001) Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1. Mech. Dev. 102 95-105 PubMed GONUTS page