GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:15145949
| Citation |
Aoki, M, Yamashita, T and Tohyama, M (2004) EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway. J. Biol. Chem. 279:32643-50 |
|---|---|
| Abstract |
Ephrins are cell surface-associated ligands for Eph receptor tyrosine kinases and are implicated in repulsive axon guidance and cell migration. EphA2, 3, and 4 receptors and one of their cognate ligands, ephrin-A2, are expressed by cells in the subventricular zone and ganglionic eminence of the embryonic day 14.5 telencephalon and by neural precursor cells in vitro. Activation of EphA receptors in dissociated neural precursor cells in vitro facilitates the commitment to neuronal fates. The majority of ephrin-A1-induced neurons is immunoreactive for tyrosine hydroxylase. Blocking the signal by the extracellular domain of EphA in forebrain slices results in a decrease in neurogenesis. Extracellular signal-regulated kinase is activated by the ligand binding to EphA receptors and is involved in the neurogenesis through EphA receptors. Rap1, but not Ras, is activated in response to ephrin-A1. Our results identify EphA receptors as positive regulators of the mitogen-activated protein kinase pathway that exerts neurogenesis of neural precursor cells from the developing central nervous system. |
| Links |
PubMed Online version:10.1074/jbc.M313247200 |
| Keywords |
Animals; Brain/embryology; Cell Differentiation; Cell Division; Cell Movement; Cells, Cultured/metabolism; Central Nervous System/embryology; Culture Media; Ephrin-A2/metabolism; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; MAP Kinase Signaling System; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases/metabolism; Neurons/metabolism; Precipitin Tests; Protein Structure, Tertiary; RNA/metabolism; Receptors, Eph Family/chemistry; Receptors, Eph Family/physiology; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tyrosine/metabolism; Tyrosine 3-Monooxygenase/metabolism; rap1 GTP-Binding Proteins/metabolism; ras Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
