GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:EAA2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Slc1a2 (synonyms: Eaat2, Glt1)
Protein Name(s) Excitatory amino acid transporter 2

GLT-1 Sodium-dependent glutamate/aspartate transporter 2 Solute carrier family 1 member 2

External Links
UniProt P43006
EMBL U11763
D43796
U24699
U75372
U75373
AB007810
AB007811
AB007812
CCDS CCDS16469.1
CCDS38188.1
CCDS38189.1
PIR A55676
JC4262
RefSeq NP_001070982.1
NP_001070983.1
NP_035523.1
UniGene Mm.267547
Mm.371582
ProteinModelPortal P43006
SMR P43006
BioGrid 203290
IntAct P43006
MINT MINT-4093909
PhosphoSite P43006
MaxQB P43006
PaxDb P43006
PRIDE P43006
Ensembl ENSMUST00000005220
ENSMUST00000080210
ENSMUST00000111212
GeneID 20511
KEGG mmu:20511
UCSC uc008lid.2
CTD 6506
MGI MGI:101931
eggNOG COG1301
GeneTree ENSGT00760000119117
HOGENOM HOG000208776
HOVERGEN HBG000080
InParanoid P43006
KO K05613
OMA FIAFGIC
OrthoDB EOG7RV9G2
PhylomeDB P43006
TreeFam TF315206
Reactome REACT_251788
REACT_255654
ChiTaRS Slc1a2
NextBio 298703
PRO PR:P43006
Proteomes UP000000589
Bgee P43006
ExpressionAtlas P43006
Genevestigator P43006
GO GO:0030673
GO:0030424
GO:0005887
GO:0015501
GO:0005313
GO:0017153
GO:0030534
GO:0031668
GO:0070779
GO:0051938
GO:0089711
GO:0015813
GO:0035264
GO:0010259
GO:0007399
GO:0046326
GO:0043200
GO:0042493
GO:0009416
GO:0009611
GO:0021537
GO:0007632
Gene3D 1.10.3860.10
InterPro IPR001991
IPR018107
PANTHER PTHR11958
Pfam PF00375
PRINTS PR00173
SUPFAM SSF118215
PROSITE PS00713
PS00714

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010468

regulation of gene expression

PMID:24569372[1]

ECO:0000315

P

Figure 4 shows LDN/OSU-0212320 delays motor function decline and extends lifespan in SOD1(G93A) mice

complete
CACAO 10537

part_of

GO:0005887

integral component of plasma membrane

PMID:9373176[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0098712

L-glutamate import across plasma membrane

PMID:9373176[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005314

high-affinity glutamate transmembrane transporter activity

PMID:9373176[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P43004

C

Seeded From UniProt

complete

involved_in

GO:0098712

L-glutamate import across plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P43004

P

Seeded From UniProt

complete

involved_in

GO:0070207

protein homotrimerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P43004

P

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:25834045[3]

ECO:0001225

knockout evidence used in manual assertion

C

part_of:(UBERON:0001890)

Seeded From UniProt

complete

involved_in

GO:0098810

neurotransmitter reuptake

PMID:25834045[3]

ECO:0001225

knockout evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0001890)

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098712

L-glutamate import across plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098656

anion transmembrane transport

PMID:24307171[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070779

D-aspartate import across plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070207

protein homotrimerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046326

positive regulation of glucose import

PMID:16197522[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043200

response to amino acid

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

part_of

GO:0043198

dendritic shaft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

C

Seeded From UniProt

complete

part_of

GO:0043197

dendritic spine

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

C

Seeded From UniProt

complete

part_of

GO:0042734

presynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:9539795[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

occurs_in:(EMAPA:17168)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035264

multicellular organism growth

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031668

cellular response to extracellular stimulus

PMID:16197522[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

part_of

GO:0030673

axolemma

PMID:9671661[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17583)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030534

adult behavior

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:9671661[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17583)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021537

telencephalon development

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

results_in_development_of:(EMAPA:16910)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:29350434[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015813

L-glutamate transmembrane transport

PMID:15009636[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015813

L-glutamate transmembrane transport

PMID:7698742[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015813

L-glutamate transmembrane transport

PMID:24307171[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015813

L-glutamate transmembrane transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015813

L-glutamate transmembrane transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

P

Seeded From UniProt

complete

enables

GO:0015501

glutamate:sodium symporter activity

PMID:7698742[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015501

glutamate:sodium symporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

F

Seeded From UniProt

complete

enables

GO:0015501

glutamate:sodium symporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010259

multicellular organism aging

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009611

response to wounding

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009416

response to light stimulus

PMID:9539795[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

occurs_in:(EMAPA:17168)

Seeded From UniProt

complete

enables

GO:0008509

anion transmembrane transporter activity

PMID:24307171[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007632

visual behavior

PMID:16197522[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007399

nervous system development

PMID:9180080[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449707

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:7698742[11]

ECO:0000305

curator inference used in manual assertion

GO:0015501

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:24307171[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

C

Seeded From UniProt

complete

enables

GO:0005314

high-affinity glutamate transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

F

Seeded From UniProt

complete

enables

GO:0005314

high-affinity glutamate transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3697

F

Seeded From UniProt

complete

enables

GO:0005313

L-glutamate transmembrane transporter activity

PMID:15009636[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005313

L-glutamate transmembrane transporter activity

PMID:24307171[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005313

L-glutamate transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43004

F

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

C

Seeded From UniProt

complete

involved_in

GO:0098712

L-glutamate import across plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

P

Seeded From UniProt

complete

involved_in

GO:0070779

D-aspartate import across plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

P

Seeded From UniProt

complete

involved_in

GO:0070207

protein homotrimerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

P

Seeded From UniProt

complete

involved_in

GO:0015813

L-glutamate transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

P

Seeded From UniProt

complete

enables

GO:0015501

glutamate:sodium symporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

C

Seeded From UniProt

complete

enables

GO:0005314

high-affinity glutamate transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

F

Seeded From UniProt

complete

enables

GO:0005313

L-glutamate transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43004
ensembl:ENSP00000278379

F

Seeded From UniProt

complete

enables

GO:0015293

symporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001991
InterPro:IPR036458

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001991
InterPro:IPR036458

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0015293

symporter activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0769

F

Seeded From UniProt

complete

involved_in

GO:0006865

amino acid transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0029

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Kong, Q et al. (2014) Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J. Clin. Invest. 124 1255-67 PubMed GONUTS page
  2. 2.0 2.1 2.2 Utsunomiya-Tate, N et al. (1997) Tissue specific variants of glutamate transporter GLT-1. FEBS Lett. 416 312-6 PubMed GONUTS page
  3. 3.0 3.1 Petr, GT et al. (2015) Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J. Neurosci. 35 5187-201 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Schneider, N et al. (2014) Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 289 1815-24 PubMed GONUTS page
  5. 5.0 5.1 5.2 Herard, AS et al. (2005) Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1. Eur. J. Neurosci. 22 1807-11 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Tanaka, K et al. (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 1699-702 PubMed GONUTS page
  7. 7.0 7.1 Harada, T et al. (1998) Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc. Natl. Acad. Sci. U.S.A. 95 4663-6 PubMed GONUTS page
  8. 8.0 8.1 Yamada, K et al. (1998) Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression. J. Neurosci. 18 5706-13 PubMed GONUTS page
  9. Ottestad-Hansen, S et al. (2018) The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia 66 951-970 PubMed GONUTS page
  10. 10.0 10.1 Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page
  11. 11.0 11.1 11.2 Kirschner, MA et al. (1994) Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics 24 218-24 PubMed GONUTS page