MOUSE:EAA2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc1a2 (synonyms: Eaat2, Glt1)
Protein Name(s)	Excitatory amino acid transporter 2 GLT-1 Sodium-dependent glutamate/aspartate transporter 2 Solute carrier family 1 member 2
External Links
UniProt	P43006
EMBL	U11763 D43796 U24699 U75372 U75373 AB007810 AB007811 AB007812
CCDS	CCDS16469.1 CCDS38188.1 CCDS38189.1
PIR	A55676 JC4262
RefSeq	NP_001070982.1 NP_001070983.1 NP_035523.1
UniGene	Mm.267547 Mm.371582
ProteinModelPortal	P43006
SMR	P43006
BioGrid	203290
IntAct	P43006
MINT	MINT-4093909
PhosphoSite	P43006
MaxQB	P43006
PaxDb	P43006
PRIDE	P43006
Ensembl	ENSMUST00000005220 ENSMUST00000080210 ENSMUST00000111212
GeneID	20511
KEGG	mmu:20511
UCSC	uc008lid.2
CTD	6506
MGI	MGI:101931
eggNOG	COG1301
GeneTree	ENSGT00760000119117
HOGENOM	HOG000208776
HOVERGEN	HBG000080
InParanoid	P43006
KO	K05613
OMA	FIAFGIC
OrthoDB	EOG7RV9G2
PhylomeDB	P43006
TreeFam	TF315206
Reactome	REACT_251788 REACT_255654
ChiTaRS	Slc1a2
NextBio	298703
PRO	PR:P43006
Proteomes	UP000000589
Bgee	P43006
ExpressionAtlas	P43006
Genevestigator	P43006
GO	GO:0030673 GO:0030424 GO:0005887 GO:0015501 GO:0005313 GO:0017153 GO:0030534 GO:0031668 GO:0070779 GO:0051938 GO:0089711 GO:0015813 GO:0035264 GO:0010259 GO:0007399 GO:0046326 GO:0043200 GO:0042493 GO:0009416 GO:0009611 GO:0021537 GO:0007632
Gene3D	1.10.3860.10
InterPro	IPR001991 IPR018107
PANTHER	PTHR11958
Pfam	PF00375
PRINTS	PR00173
SUPFAM	SSF118215
PROSITE	PS00713 PS00714

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010468	regulation of gene expression	PMID:24569372^[1]	ECO:0000315			P		Figure 4 shows LDN/OSU-0212320 delays motor function decline and extends lifespan in SOD1(G93A) mice	complete CACAO 10537
part_of	GO:0005887	integral component of plasma membrane	PMID:9373176^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098712	L-glutamate import across plasma membrane	PMID:9373176^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005314	high-affinity glutamate transmembrane transporter activity	PMID:9373176^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43004	C		Seeded From UniProt	complete
involved_in	GO:0098712	L-glutamate import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43004	P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43004	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:25834045^[3]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0001890)	Seeded From UniProt	complete
involved_in	GO:0098810	neurotransmitter reuptake	PMID:25834045^[3]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0001890)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098712	L-glutamate import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098656	anion transmembrane transport	PMID:24307171^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070779	D-aspartate import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070207	protein homotrimerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046326	positive regulation of glucose import	PMID:16197522^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043200	response to amino acid	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	PMID:9539795^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031668	cellular response to extracellular stimulus	PMID:16197522^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
part_of	GO:0030673	axolemma	PMID:9671661^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17583) part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030534	adult behavior	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:9671661^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17583) part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P	results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:29350434^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	PMID:15009636^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	PMID:7698742^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	PMID:24307171^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	P		Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	PMID:7698742^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	F		Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010259	multicellular organism aging	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009416	response to light stimulus	PMID:9539795^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
enables	GO:0008509	anion transmembrane transporter activity	PMID:24307171^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007632	visual behavior	PMID:16197522^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:9180080^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449707	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7698742^[11]	ECO:0000305	curator inference used in manual assertion	GO:0015501	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24307171^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	C		Seeded From UniProt	complete
enables	GO:0005314	high-affinity glutamate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	F		Seeded From UniProt	complete
enables	GO:0005314	high-affinity glutamate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3697	F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	PMID:15009636^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	PMID:24307171^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43004	F		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	C		Seeded From UniProt	complete
involved_in	GO:0098712	L-glutamate import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	P		Seeded From UniProt	complete
involved_in	GO:0070779	D-aspartate import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	P		Seeded From UniProt	complete
involved_in	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	P		Seeded From UniProt	complete
enables	GO:0015501	glutamate:sodium symporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	C		Seeded From UniProt	complete
enables	GO:0005314	high-affinity glutamate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43004 ensembl:ENSP00000278379	F		Seeded From UniProt	complete
enables	GO:0015293	symporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001991 InterPro:IPR036458	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001991 InterPro:IPR036458	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0015293	symporter activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0769	F		Seeded From UniProt	complete
involved_in	GO:0006865	amino acid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0029	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kong, Q et al. (2014) Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J. Clin. Invest. 124 1255-67 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Utsunomiya-Tate, N et al. (1997) Tissue specific variants of glutamate transporter GLT-1. FEBS Lett. 416 312-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Petr, GT et al. (2015) Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J. Neurosci. 35 5187-201 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Schneider, N et al. (2014) Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 289 1815-24 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Herard, AS et al. (2005) Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1. Eur. J. Neurosci. 22 1807-11 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Tanaka, K et al. (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 1699-702 PubMed GONUTS page
↑ ^7.0 ^7.1 Harada, T et al. (1998) Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc. Natl. Acad. Sci. U.S.A. 95 4663-6 PubMed GONUTS page
↑ ^8.0 ^8.1 Yamada, K et al. (1998) Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression. J. Neurosci. 18 5706-13 PubMed GONUTS page
↑ Ottestad-Hansen, S et al. (2018) The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia 66 951-970 PubMed GONUTS page
↑ ^10.0 ^10.1 Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Kirschner, MA et al. (1994) Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics 24 218-24 PubMed GONUTS page

[PMID:24569372-1] Kong, Q et al. (2014) Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J. Clin. Invest. 124 1255-67 PubMed GONUTS page

[PMID:9373176-2] 2.0 ^2.1 ^2.2 Utsunomiya-Tate, N et al. (1997) Tissue specific variants of glutamate transporter GLT-1. FEBS Lett. 416 312-6 PubMed GONUTS page

[PMID:25834045-3] 3.0 ^3.1 Petr, GT et al. (2015) Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J. Neurosci. 35 5187-201 PubMed GONUTS page

[PMID:24307171-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Schneider, N et al. (2014) Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 289 1815-24 PubMed GONUTS page

[PMID:16197522-5] 5.0 ^5.1 ^5.2 Herard, AS et al. (2005) Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1. Eur. J. Neurosci. 22 1807-11 PubMed GONUTS page

[PMID:9180080-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Tanaka, K et al. (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 1699-702 PubMed GONUTS page

[PMID:9539795-7] 7.0 ^7.1 Harada, T et al. (1998) Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc. Natl. Acad. Sci. U.S.A. 95 4663-6 PubMed GONUTS page

[PMID:9671661-8] 8.0 ^8.1 Yamada, K et al. (1998) Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression. J. Neurosci. 18 5706-13 PubMed GONUTS page

[PMID:29350434-9] Ottestad-Hansen, S et al. (2018) The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia 66 951-970 PubMed GONUTS page

[PMID:15009636-10] 10.0 ^10.1 Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page

[PMID:7698742-11] 11.0 ^11.1 ^11.2 Kirschner, MA et al. (1994) Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics 24 218-24 PubMed GONUTS page

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MOUSE:EAA2

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