MOUSE:DNM3A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dnmt3a
Protein Name(s)	DNA (cytosine-5)-methyltransferase 3A Dnmt3a DNA methyltransferase MmuIIIA DNA MTase MmuIIIA M.MmuIIIA
External Links
UniProt	O88508
EMBL	AF068625 AF480164 AK013096 AK090132 AK147263 AK147627 AK147642 AK147676 AK157792 BC007466
CCDS	CCDS25784.1 CCDS36397.1
RefSeq	NP_001258682.1 NP_031898.1 NP_714965.1 XP_006515016.1 XP_006515017.1 XP_006515018.1 XP_006515019.1 XP_006515020.1
UniGene	Mm.470389 Mm.5001
PDB	3SW9 3SWC
PDBsum	3SW9 3SWC
ProteinModelPortal	O88508
SMR	O88508
BioGrid	199261
DIP	DIP-38005N
IntAct	O88508
MINT	MINT-2521021
ChEMBL	CHEMBL3108652
REBASE	3747
PhosphoSite	O88508
MaxQB	O88508
PaxDb	O88508
PRIDE	O88508
Ensembl	ENSMUST00000020991 ENSMUST00000111186 ENSMUST00000172689 ENSMUST00000174817
GeneID	13435
KEGG	mmu:13435
UCSC	uc007mxb.1
CTD	1788
MGI	MGI:1261827
eggNOG	NOG70699
GeneTree	ENSGT00390000008341
HOGENOM	HOG000230875
HOVERGEN	HBG051381
InParanoid	O88508
KO	K17398
OMA	FVGGMCQ
OrthoDB	EOG7MWGW6
PhylomeDB	O88508
TreeFam	TF329039
BRENDA	2.1.1.37
Reactome	REACT_222475 REACT_244207 REACT_268475
ChiTaRS	Dnmt3a
NextBio	283867
PRO	PR:O88508
Proteomes	UP000000589
Bgee	O88508
CleanEx	MM_DNMT3A
ExpressionAtlas	O88508
Genevestigator	O88508
GO	GO:0000775 GO:0005737 GO:0000791 GO:0000792 GO:0005720 GO:0016363 GO:0005634 GO:0001741 GO:0003682 GO:0003886 GO:0051718 GO:0003677 GO:0046872 GO:0008168 GO:0045322 GO:0090116 GO:0071230 GO:0006306 GO:0043045 GO:0043046 GO:0010424 GO:0044027 GO:0010216 GO:0006346 GO:0000122 GO:0006349 GO:0046498 GO:0046499 GO:0007283 GO:0006351
Gene3D	3.40.50.150
InterPro	IPR025766 IPR018117 IPR001525 IPR000313 IPR029063
Pfam	PF00855
SMART	SM00293
SUPFAM	SSF53335
PROSITE	PS51533 PS00094 PS50812 PS51679

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0043046	DNA methylation involved in gamete generation	PMID:15215868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043045	DNA methylation involved in embryo development	PMID:15215868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K1	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14752048^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	PMID:15456878^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043045	DNA methylation involved in embryo development	PMID:10555141^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043045	DNA methylation involved in embryo development	PMID:20385583^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032776	DNA methylation on cytosine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303336	P		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303336	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:11934864^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182412	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006349	regulation of gene expression by genetic imprinting	PMID:15215868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3047552 MGI:MGI:3047824	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006349	regulation of gene expression by genetic imprinting	PMID:11934864^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182412	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006346	methylation-dependent chromatin silencing	PMID:17938196^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261819	P	has_regulation_target:(MGI:MGI:101893)\|has_regulation_target:(MGI:MGI:1919200)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006346	methylation-dependent chromatin silencing	PMID:16322236^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	PMID:17938196^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261819	P	has_participant:(MGI:MGI:101893)\|has_participant:(MGI:MGI:1919200)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	PMID:11934864^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	PMID:11399089^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006306	DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15739230^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962) part_of:(CL:0000023)\|part_of:(EMAPA:18686) part_of:(CL:0000020)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303336	C		Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:11934864^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20577743^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303336	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:17938196^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1261819	F	has_participant:(MGI:MGI:101893)	Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:9662389^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:11399089^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16322236^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:97171)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303336	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11399089^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
part_of	GO:0001741	XY body	PMID:20577743^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:16322236^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16322236^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K1	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0051719	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003886	P		Seeded From UniProt	complete
involved_in	GO:0097284	hepatocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0032776	DNA methylation on cytosine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	F		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ53 ensembl:ENSRNOP00000046524	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	F		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	F		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	C		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	F		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6K1 ensembl:ENSP00000264709	P		Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030487	P		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001525	F		Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030487	F		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030487	P		Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.37	F		Seeded From UniProt	complete
involved_in	GO:0044027	hypermethylation of CpG island	PMID:21047779^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	PMID:21047779^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051719	DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates	Reactome:R-MMU-5336316	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-5336316 Reactome:R-MMU-5334134 Reactome:R-MMU-4655387	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	PMID:11934864^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
involved_in	GO:0010216	maintenance of DNA methylation	PMID:21047779^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kaneda, M et al. (2004) Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429 900-3 PubMed GONUTS page
↑ Ling, Y et al. (2004) Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 32 598-610 PubMed GONUTS page
↑ Chen, T et al. (2004) The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol. Cell. Biol. 24 9048-58 PubMed GONUTS page
↑ Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page
↑ Okano, M et al. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 247-57 PubMed GONUTS page
↑ Hiura, H et al. (2010) A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res. 38 4929-45 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hata, K et al. (2002) Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129 1983-93 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Li, JY et al. (2007) Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol. Cell. Biol. 27 8748-59 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Datta, J et al. (2005) Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. Cancer Res. 65 10891-900 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gowher, H & Jeltsch, A (2001) Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites. J. Mol. Biol. 309 1201-8 PubMed GONUTS page
↑ Lees-Murdock, DJ et al. (2005) DNA methyltransferase expression in the mouse germ line during periods of de novo methylation. Dev. Dyn. 232 992-1002 PubMed GONUTS page
↑ ^12.0 ^12.1 Saferali, A et al. (2010) Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mamm. Genome 21 377-87 PubMed GONUTS page
↑ Okano, M et al. (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 19 219-20 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Popkie, AP et al. (2010) Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J. Biol. Chem. 285 41337-47 PubMed GONUTS page

[PMID:15215868-1] 1.0 ^1.1 ^1.2 Kaneda, M et al. (2004) Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429 900-3 PubMed GONUTS page

[PMID:14752048-2] Ling, Y et al. (2004) Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 32 598-610 PubMed GONUTS page

[PMID:15456878-3] Chen, T et al. (2004) The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol. Cell. Biol. 24 9048-58 PubMed GONUTS page

[PMID:20548288-4] Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page

[PMID:10555141-5] Okano, M et al. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 247-57 PubMed GONUTS page

[PMID:20385583-6] Hiura, H et al. (2010) A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res. 38 4929-45 PubMed GONUTS page

[PMID:11934864-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hata, K et al. (2002) Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129 1983-93 PubMed GONUTS page

[PMID:17938196-8] 8.0 ^8.1 ^8.2 Li, JY et al. (2007) Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol. Cell. Biol. 27 8748-59 PubMed GONUTS page

[PMID:16322236-9] 9.0 ^9.1 ^9.2 ^9.3 Datta, J et al. (2005) Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. Cancer Res. 65 10891-900 PubMed GONUTS page

[PMID:11399089-10] 10.0 ^10.1 ^10.2 Gowher, H & Jeltsch, A (2001) Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites. J. Mol. Biol. 309 1201-8 PubMed GONUTS page

[PMID:15739230-11] Lees-Murdock, DJ et al. (2005) DNA methyltransferase expression in the mouse germ line during periods of de novo methylation. Dev. Dyn. 232 992-1002 PubMed GONUTS page

[PMID:20577743-12] 12.0 ^12.1 Saferali, A et al. (2010) Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mamm. Genome 21 377-87 PubMed GONUTS page

[PMID:9662389-13] Okano, M et al. (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 19 219-20 PubMed GONUTS page

[PMID:21047779-14] 14.0 ^14.1 ^14.2 Popkie, AP et al. (2010) Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J. Biol. Chem. 285 41337-47 PubMed GONUTS page

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MOUSE:DNM3A

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