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MOUSE:DND1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Dnd1 (synonyms: Rbms4, Ter)
Protein Name(s) Dead end protein homolog 1

RNA-binding motif, single-stranded-interacting protein 4

External Links
UniProt Q6VY05
EMBL AY321066
BC034897
CCDS CCDS29163.2
RefSeq NP_775559.2
UniGene Mm.234464
ProteinModelPortal Q6VY05
SMR Q6VY05
BioGrid 229409
STRING 10090.ENSMUSP00000054412
iPTMnet Q6VY05
PhosphoSitePlus Q6VY05
PaxDb Q6VY05
PeptideAtlas Q6VY05
PRIDE Q6VY05
Ensembl ENSMUST00000061522
GeneID 213236
KEGG mmu:213236
UCSC uc008eom.1
uc008eon.1
CTD 373863
MGI MGI:2447763
eggNOG ENOG410IUE0
ENOG410YAVC
GeneTree ENSGT00550000074366
HOGENOM HOG000112240
HOVERGEN HBG051370
InParanoid Q6VY05
OMA QSKRECE
OrthoDB EOG091G0EUB
PhylomeDB Q6VY05
TreeFam TF314932
PRO PR:Q6VY05
Proteomes UP000000589
Bgee ENSMUSG00000044595
CleanEx MM_DND1
Genevisible Q6VY05
GO GO:0005737
GO:0005634
GO:0017091
GO:0000166
GO:0007281
GO:0007275
GO:0060965
Gene3D 3.30.70.330
InterPro IPR012677
IPR000504
Pfam PF00076
SMART SM00360
SUPFAM SSF54928
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043066

negative regulation of apoptotic process

PMID:28297718[1]

ECO:0000314

P

Paper's Protein Name: RNA-binding protein DND1. UniProt's Protein Name: Dead end protein homolog 1. Organism: Mus musculus (Mouse). Notes: This paper deals with the destabilization of specific mRNA segments by the protein Dnd1. One example of this involves apoptosis. When Dnd1 is mutated and loses function, there is “an upregulation of DND1 PAR-CLIP targets... including positive regulators of apoptosis.” More importantly, Extended figure 6g shows that after GSCs are transduced with DND1’s shRNA targets, cell death occurs within 4 days. The paper also states that “Annexin V-positive cells represent early apoptotic cells and are gated as P8 population (green)” in Extended Figure 6i. As can be seen in the figure, there are clearly more “early apoptotic cells” when the cells in question are transduced with DND1’s shRNA targets. It appears that the process for transduction was done with shRNA targets originating from mice, as is listed in Supplementary Table 9.

complete
CACAO 12319

GO:0023056

positive regulation of signaling

PMID:28297718[1]

ECO:0000314

P

Paper's Protein Name: RNA-binding protein DND1. UniProt's Protein Name: Dead end protein homolog 1. Organism: Mus musculus (Mouse). Notes: “Pathway analysis of the top 300 DND1 targets showed enrichment for genes associated with signalling pathways regulating pluripotent stem cells and cancer development (for example, TGFβ, WNT and PI3K–AKT signalling) (Extended Data Fig. 4, Supplementary Table 3)."

complete
CACAO 12320

involved_in

GO:0060965

negative regulation of gene silencing by miRNA

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IYX4

P

Seeded From UniProt

complete

NOT|enables

GO:0035198

miRNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IYX4

F

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IYX4

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18509452[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IYX4

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8IYX4

C

Seeded From UniProt

complete

involved_in

GO:0060965

negative regulation of gene silencing by miRNA

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723154
UniProtKB:Q8IYX4

P

Seeded From UniProt

complete

involved_in

GO:0048255

mRNA stabilization

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723154
ZFIN:ZDB-GENE-030828-4

P

Seeded From UniProt

complete

enables

GO:0017091

AU-rich element binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723154
UniProtKB:Q8IYX4

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2447763
PANTHER:PTN002723154
UniProtKB:F1RGE0
UniProtKB:Q8IYX4
ZFIN:ZDB-GENE-030828-4

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891690
MGI:MGI:1891692
MGI:MGI:1917115
MGI:MGI:2384294
MGI:MGI:3645057
PANTHER:PTN002723140
RGD:1305683
RGD:619834
RGD:631348
UniProtKB:A0A0B4KHI4
UniProtKB:F1RGE0
UniProtKB:O43390
UniProtKB:O60506
UniProtKB:Q8IYX4
UniProtKB:Q9NQ94
WB:WBGene00002000
ZFIN:ZDB-GENE-030828-4

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723140
RGD:1305683
RGD:619834
RGD:631348
UniProtKB:A0A0B4KHI4
UniProtKB:F1RGE0
ZFIN:ZDB-GENE-030828-4
ZFIN:ZDB-GENE-040426-2766

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891690
MGI:MGI:2384294
MGI:MGI:3645057
PANTHER:PTN002723139
RGD:1305683
RGD:619834
RGD:631348
UniProtKB:A0A0B4KHI4
UniProtKB:F1RGE0
UniProtKB:Q8IYX4
UniProtKB:Q9NQ94
ZFIN:ZDB-GENE-030828-4
ZFIN:ZDB-GENE-040426-2766

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060965

negative regulation of gene silencing by miRNA

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IYX4

P

Seeded From UniProt

complete

enables

GO:0017091

AU-rich element binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IYX4

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007281

germ cell development

PMID:15902260[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158668

P

  • occurs_in:(EMAPA:17381)
  • results_in_development_of:(CL:0000586)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IYX4

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8IYX4

C

Seeded From UniProt

complete

involved_in

GO:0060965

negative regulation of gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IYX4
ensembl:ENSP00000445366

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IYX4
ensembl:ENSP00000445366

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IYX4
ensembl:ENSP00000445366

C

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8IYX4
ensembl:ENSP00000445366

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR035979

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Yamaji, M et al. (2017) DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs. Nature PubMed GONUTS page
  2. ↑ Bhattacharya, C et al. (2008) Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1). PLoS ONE 3 e2315 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Youngren, KK et al. (2005) The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature 435 360-4 PubMed GONUTS page
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