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MOUSE:DKC1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Dkc1 | |
| Protein Name(s) | H/ACA ribonucleoprotein complex subunit 4
Dyskerin Nopp140-associated protein of 57 kDa Nucleolar protein NAP57 Nucleolar protein family A member 4 snoRNP protein DKC1 | |
| External Links | ||
| UniProt | Q9ESX5 | |
| EMBL | AJ250973 AJ250972 AJ250974 AJ250975 AJ250976 AJ250978 AJ250980 AJ250981 AJ250979 AJ250977 AK136418 AL808110 | |
| CCDS | CCDS41029.1 | |
| RefSeq | NP_001025478.1 | |
| UniGene | Mm.291062 | |
| ProteinModelPortal | Q9ESX5 | |
| SMR | Q9ESX5 | |
| BioGrid | 232777 | |
| IntAct | Q9ESX5 | |
| MINT | MINT-1854010 | |
| PhosphoSite | Q9ESX5 | |
| MaxQB | Q9ESX5 | |
| PaxDb | Q9ESX5 | |
| PRIDE | Q9ESX5 | |
| Ensembl | ENSMUST00000033776 | |
| GeneID | 245474 | |
| KEGG | mmu:245474 | |
| UCSC | uc009tpo.2 | |
| CTD | 1736 | |
| MGI | MGI:1861727 | |
| eggNOG | COG0130 | |
| GeneTree | ENSGT00510000047092 | |
| HOGENOM | HOG000231224 | |
| HOVERGEN | HBG081442 | |
| InParanoid | Q9ESX5 | |
| KO | K11131 | |
| OMA | AVEMSSC | |
| OrthoDB | EOG7QC7W0 | |
| TreeFam | TF300354 | |
| Reactome | REACT_262572 | |
| NextBio | 386727 | |
| PRO | PR:Q9ESX5 | |
| Proteomes | UP000000589 | |
| Bgee | Q9ESX5 | |
| ExpressionAtlas | Q9ESX5 | |
| Genevestigator | Q9ESX5 | |
| GO | GO:0015030 GO:0005730 GO:0005697 GO:0044822 GO:0009982 GO:0004730 GO:0003723 GO:0030519 GO:0003720 GO:0006396 GO:0000154 | |
| Gene3D | 2.30.130.10 | |
| InterPro | IPR012960 IPR002501 IPR020103 IPR002478 IPR015947 IPR004802 IPR004521 | |
| PANTHER | PTHR23127 | |
| Pfam | PF08068 PF01472 PF01509 | |
| SMART | SM00359 | |
| SUPFAM | SSF55120 SSF88697 | |
| TIGRFAMs | TIGR00425 TIGR00451 | |
| PROSITE | PS50890 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005697 |
telomerase holoenzyme complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007004 |
telomere maintenance via telomerase |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000455 |
enzyme-directed rRNA pseudouridine synthesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990481 |
mRNA pseudouridine synthesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000565614 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031429 |
box H/ACA snoRNP complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000565614 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031120 |
snRNA pseudouridine synthesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000565614 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031118 |
rRNA pseudouridine synthesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861727 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000565614 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000495 |
box H/ACA snoRNA 3'-end processing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000565614 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1904874 |
positive regulation of telomerase RNA localization to Cajal body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1904872 |
regulation of telomerase RNA localization to Cajal body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1904851 |
positive regulation of establishment of protein localization to telomere |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090669 |
telomerase RNA stabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090666 |
scaRNA localization to Cajal body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0090661 |
box H/ACA telomerase RNP complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070034 |
telomerase RNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051973 |
positive regulation of telomerase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3849598 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051973 |
positive regulation of telomerase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034513 |
box H/ACA snoRNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033979 |
box H/ACA snoRNA metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2446500 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032212 |
positive regulation of telomere maintenance via telomerase |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3849598 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031429 |
box H/ACA snoRNP complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031429 |
box H/ACA snoRNP complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621780 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0031118 |
rRNA pseudouridine synthesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2446500 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0031118 |
rRNA pseudouridine synthesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3849598 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0015030 |
Cajal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015030 |
Cajal body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621780 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621780 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007004 |
telomere maintenance via telomerase |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621780 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005697 |
telomerase holoenzyme complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621780 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003720 |
telomerase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0003720 |
telomerase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001650 |
fibrillar center |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000455 |
enzyme-directed rRNA pseudouridine synthesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000454 |
snoRNA guided rRNA pseudouridine synthesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621780 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904874 |
positive regulation of telomerase RNA localization to Cajal body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904872 |
regulation of telomerase RNA localization to Cajal body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904851 |
positive regulation of establishment of protein localization to telomere |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090669 |
telomerase RNA stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090666 |
scaRNA localization to Cajal body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0090661 |
box H/ACA telomerase RNP complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070034 |
telomerase RNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051973 |
positive regulation of telomerase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034513 |
box H/ACA snoRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031429 |
box H/ACA snoRNP complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007004 |
telomere maintenance via telomerase |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005697 |
telomerase holoenzyme complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003720 |
telomerase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001650 |
fibrillar center |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000455 |
enzyme-directed rRNA pseudouridine synthesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O60832 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001522 |
pseudouridine synthesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006396 |
RNA processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009451 |
RNA modification |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009982 |
pseudouridine synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042254 |
ribosome biogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015030 |
Cajal body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Mochizuki, Y et al. (2004) Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing. Proc. Natl. Acad. Sci. U.S.A. 101 10756-61 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gu, BW et al. (2013) Slow growth and unstable ribosomal RNA lacking pseudouridine in mouse embryonic fibroblast cells expressing catalytically inactive dyskerin. FEBS Lett. 587 2112-7 PubMed GONUTS page
b
e
g
m
p
- GO:0032212 ! positive regulation of telomere maintenance via telomerase
- GO:1904874 ! positive regulation of telomerase RNA localization to Cajal body
- GO:1904851 ! positive regulation of establishment of protein localization to telomere
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0009982 ! pseudouridine synthase activity
- GO:0001522 ! pseudouridine synthesis
r
s
t
