MOUSE:CTLA4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ctla4 (synonyms: Cd152)
Protein Name(s)	Cytotoxic T-lymphocyte protein 4 Cytotoxic T-lymphocyte-associated antigen 4 CTLA-4
External Links
UniProt	P09793
EMBL	X05719 AF142145 M74362
CCDS	CCDS14993.1
PIR	A29063
RefSeq	NP_033973.2
UniGene	Mm.390
PDB	1DQT
PDBsum	1DQT
ProteinModelPortal	P09793
SMR	P09793
BioGrid	198575
IntAct	P09793
MINT	MINT-8019867
PhosphoSite	P09793
PRIDE	P09793
GeneID	12477
KEGG	mmu:12477
CTD	1493
MGI	MGI:88556
eggNOG	NOG42442
HOGENOM	HOG000112047
HOVERGEN	HBG057978
InParanoid	P09793
KO	K06538
PhylomeDB	P09793
EvolutionaryTrace	P09793
NextBio	281362
PRO	PR:P09793
Proteomes	UP000000589
CleanEx	MM_CTLA4
Genevestigator	P09793
GO	GO:0009897 GO:0016021 GO:0006955
Gene3D	2.60.40.10
InterPro	IPR008096 IPR007110 IPR013783 IPR003599 IPR013106
Pfam	PF07686
PRINTS	PR01720
SMART	SM00409
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16410	C		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000160996 UniProtKB:P16410	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN002608477	P		Seeded From UniProt	complete
involved_in	GO:0045590	negative regulation of regulatory T cell differentiation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000160996 UniProtKB:P16410	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 MGI:MGI:88556 PANTHER:PTN002608477 UniProtKB:P10747 UniProtKB:P16410	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88327 PANTHER:PTN002608477 RGD:2299 UniProtKB:P10747 UniProtKB:P16410	P		Seeded From UniProt	complete
part_of	GO:0098636	protein complex involved in cell adhesion	PMID:7544393^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050853	B cell receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050777	negative regulation of immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61975	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045590	negative regulation of regulatory T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	P		Seeded From UniProt	complete
part_of	GO:0045334	clathrin-coated endocytic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042130	negative regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61975	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16227984^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000624)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16410	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008096	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008096	C		Seeded From UniProt	complete
involved_in	GO:0042129	regulation of T cell proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040216	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page
↑ Fontenot, JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6 1142-51 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7544393-2] Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page

[PMID:16227984-3] Fontenot, JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6 1142-51 PubMed GONUTS page

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MOUSE:CTLA4

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