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MOUSE:CTLA4

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ctla4 (synonyms: Cd152)
Protein Name(s) Cytotoxic T-lymphocyte protein 4

Cytotoxic T-lymphocyte-associated antigen 4 CTLA-4

External Links
UniProt P09793
EMBL X05719
AF142145
M74362
CCDS CCDS14993.1
PIR A29063
RefSeq NP_033973.2
UniGene Mm.390
PDB 1DQT
PDBsum 1DQT
ProteinModelPortal P09793
SMR P09793
BioGrid 198575
IntAct P09793
MINT MINT-8019867
PhosphoSite P09793
PRIDE P09793
GeneID 12477
KEGG mmu:12477
CTD 1493
MGI MGI:88556
eggNOG NOG42442
HOGENOM HOG000112047
HOVERGEN HBG057978
InParanoid P09793
KO K06538
PhylomeDB P09793
EvolutionaryTrace P09793
NextBio 281362
PRO PR:P09793
Proteomes UP000000589
CleanEx MM_CTLA4
Genevestigator P09793
GO GO:0009897
GO:0016021
GO:0006955
Gene3D 2.60.40.10
InterPro IPR008096
IPR007110
IPR013783
IPR003599
IPR013106
Pfam PF07686
PRINTS PR01720
SMART SM00409
PROSITE PS50835

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16410

C

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000160996
UniProtKB:P16410

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88327
PANTHER:PTN002608477

P

Seeded From UniProt

complete

involved_in

GO:0045590

negative regulation of regulatory T cell differentiation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000160996
UniProtKB:P16410

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88327
MGI:MGI:88556
PANTHER:PTN002608477
UniProtKB:P10747
UniProtKB:P16410

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88327
PANTHER:PTN002608477
RGD:2299
UniProtKB:P10747
UniProtKB:P16410

P

Seeded From UniProt

complete

part_of

GO:0098636

protein complex involved in cell adhesion

PMID:7544393[2]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050853

B cell receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050777

negative regulation of immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:61975

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045590

negative regulation of regulatory T cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

P

Seeded From UniProt

complete

part_of

GO:0045334

clathrin-coated endocytic vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042130

negative regulation of T cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:61975

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030889

negative regulation of B cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:16227984[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000624)

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P16410

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008096

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008096

C

Seeded From UniProt

complete

involved_in

GO:0042129

regulation of T cell proliferation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040216

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Fargeas, CA et al. (1995) Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182 667-75 PubMed GONUTS page
  3. Fontenot, JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6 1142-51 PubMed GONUTS page