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MOUSE:CRTC3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Crtc3 (synonyms: Torc3)
Protein Name(s) CREB-regulated transcription coactivator 3

Transducer of regulated cAMP response element-binding protein 3 TORC-3 Transducer of CREB protein 3

External Links
UniProt Q91X84
EMBL AK144840
BC011210
CCDS CCDS21398.2
RefSeq NP_776288.2
XP_006541259.1
UniGene Mm.392175
ProteinModelPortal Q91X84
SMR Q91X84
STRING 10090.ENSMUSP00000113540
PhosphoSite Q91X84
MaxQB Q91X84
PaxDb Q91X84
PRIDE Q91X84
Ensembl ENSMUST00000122255
GeneID 70461
KEGG mmu:70461
UCSC uc009iaz.1
CTD 64784
MGI MGI:1917711
eggNOG NOG74259
GeneTree ENSGT00390000010652
HOGENOM HOG000111980
HOVERGEN HBG058314
InParanoid Q91X84
KO K16334
OMA YMGFCDG
OrthoDB EOG7MKW5P
PhylomeDB Q91X84
TreeFam TF321571
ChiTaRS Crtc3
NextBio 331677
PRO PR:Q91X84
Proteomes UP000000589
Bgee Q91X84
CleanEx MM_CRTC3
Genevestigator Q91X84
GO GO:0005737
GO:0005634
GO:0008140
GO:0097009
GO:0043951
GO:0050995
GO:0032793
GO:0045944
GO:0051289
GO:0006351
InterPro IPR024786
IPR024785
IPR024784
IPR024783
PANTHER PTHR13589
Pfam PF12886
PF12885
PF12884

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:30611118[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:30611118[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

PMID:30611118[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
UniProtKB:Q6UUV9

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040

P

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001006040
UniProtKB:Q6UUV9
WB:WBGene00021237

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
WB:WBGene00021237

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036746
MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
UniProtKB:Q6UUV9
WB:WBGene00021237

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097009

energy homeostasis

PMID:21164481[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4879976

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050995

negative regulation of lipid catabolic process

PMID:21164481[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4879976

P

  • occurs_in:(EMAPA:35926)
  • regulates_o_occurs_in:(CL:0000448)|regulates_o_occurs_in:(EMAPA:19209)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:24674967[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21164481[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:1098271)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043951

negative regulation of cAMP-mediated signaling

PMID:21164481[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042116

macrophage activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6UUV7

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6UUV7

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24768298[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002476)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24674967[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35988)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21164481[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6UUV7

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24768298[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002476)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24674967[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35988)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21164481[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042116

macrophage activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6UUV7
ensembl:ENSP00000268184

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6UUV7
ensembl:ENSP00000268184

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6UUV7
ensembl:ENSP00000268184

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

F

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Sonntag, T et al. (2019) Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. iScience 11 134-145 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Song, Y et al. (2010) CRTC3 links catecholamine signalling to energy balance. Nature 468 933-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Bruno, NE et al. (2014) Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J. 33 1027-43 PubMed GONUTS page
  5. ↑ 5.0 5.1 Luan, B et al. (2014) Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab. 19 1058-65 PubMed GONUTS page
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