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MOUSE:CRTC2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Crtc2 (synonyms: Torc2)
Protein Name(s) CREB-regulated transcription coactivator 2

Transducer of regulated cAMP response element-binding protein 2 TORC-2 Transducer of CREB protein 2

External Links
UniProt Q3U182
EMBL AK156192
AK172084
BC023831
BC032183
BC033300
CCDS CCDS38501.1
RefSeq NP_083157.1
UniGene Mm.35627
ProteinModelPortal Q3U182
SMR Q3U182
BioGrid 216678
DIP DIP-46162N
IntAct Q3U182
MaxQB Q3U182
PaxDb Q3U182
PRIDE Q3U182
Ensembl ENSMUST00000029545
GeneID 74343
KEGG mmu:74343
UCSC uc008qbt.2
CTD 200186
MGI MGI:1921593
eggNOG NOG74259
GeneTree ENSGT00390000010652
HOGENOM HOG000111980
HOVERGEN HBG058314
InParanoid Q3U182
KO K16333
OMA HTLNHQN
OrthoDB EOG7MKW5P
PhylomeDB Q3U182
TreeFam TF321571
NextBio 340497
PRO PR:Q3U182
Proteomes UP000000589
Bgee Q3U182
CleanEx MM_CRTC2
ExpressionAtlas Q3U182
Genevestigator Q3U182
GO GO:0005737
GO:0070062
GO:0005634
GO:0008140
GO:0006094
GO:0042593
GO:0043970
GO:0032793
GO:0045944
GO:0051289
GO:1901998
GO:0006351
InterPro IPR024786
IPR024785
IPR024784
IPR024783
PANTHER PTHR13589
Pfam PF12886
PF12885
PF12884

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0042593

glucose homeostasis

PMID:16308421[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

PMID:16148943[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

PMID:16148943[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16148943[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16308421[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16148943[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16308421[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
UniProtKB:Q6UUV9

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040

P

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001006040
UniProtKB:Q6UUV9
WB:WBGene00021237

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
WB:WBGene00021237

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036746
MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
UniProtKB:Q6UUV9
WB:WBGene00021237

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901998

toxin transport

PMID:23716698[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:24051374[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1343094
MGI:MGI:1343101
MGI:MGI:2155884

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:24674967[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043970

histone H3-K9 acetylation

PMID:24051374[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1343094

P

  • occurs_in:(CL:0000182)
  • has_direct_input:(MGI:MGI:95607)
  • has_direct_input:(MGI:MGI:97501)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042593

glucose homeostasis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308903

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24768298[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:24674967[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35988)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16684769[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308903

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q53ET0

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24768298[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002476)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24674967[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35988)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16684769[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308903

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308903

F

Seeded From UniProt

complete

involved_in

GO:0042593

glucose homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3LRZ1
ensembl:ENSRNOP00000068813

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53ET0
ensembl:ENSP00000357622

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

F

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Shaw, RJ et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642-6 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Koo, SH et al. (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437 1109-11 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Slater, LH et al. (2013) CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc. Natl. Acad. Sci. U.S.A. 110 9932-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 Ravnskjaer, K et al. (2013) Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J. Clin. Invest. 123 4318-28 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Bruno, NE et al. (2014) Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J. 33 1027-43 PubMed GONUTS page
  7. ↑ 7.0 7.1 Luan, B et al. (2014) Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab. 19 1058-65 PubMed GONUTS page
  8. ↑ 8.0 8.1 Ohmae, S et al. (2006) Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. J. Biol. Chem. 281 20427-39 PubMed GONUTS page
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