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MOUSE:CISY

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cs
Protein Name(s) Citrate synthase, mitochondrial

Citrate (Si)-synthase

External Links
UniProt Q9CZU6
EMBL AB056479
AK012151
AK145643
AK149990
AK163273
AK166814
AK167125
BC013554
BC029754
CCDS CCDS24273.1
RefSeq NP_080720.1
UniGene Mm.58836
ProteinModelPortal Q9CZU6
SMR Q9CZU6
BioGrid 198926
IntAct Q9CZU6
MINT MINT-1844265
ChEMBL CHEMBL2176798
PhosphoSite Q9CZU6
MaxQB Q9CZU6
PaxDb Q9CZU6
PRIDE Q9CZU6
Ensembl ENSMUST00000005826
GeneID 12974
KEGG mmu:12974
UCSC uc007hmj.1
CTD 1431
MGI MGI:88529
eggNOG COG0372
GeneTree ENSGT00390000006813
HOGENOM HOG000130831
HOVERGEN HBG005336
InParanoid Q9CZU6
KO K01647
OMA ITDYLWS
OrthoDB EOG73BVCB
PhylomeDB Q9CZU6
TreeFam TF300398
Reactome REACT_249033
UniPathway UPA00223
ChiTaRS Cs
NextBio 282742
PRO PR:Q9CZU6
Proteomes UP000000589
Bgee Q9CZU6
CleanEx MM_CS
ExpressionAtlas Q9CZU6
Genevestigator Q9CZU6
GO GO:0005759
GO:0005739
GO:0004108
GO:0046912
GO:0005975
GO:0044262
GO:0006099
Gene3D 1.10.580.10
InterPro IPR016142
IPR002020
IPR016141
IPR019810
IPR010109
PANTHER PTHR11739
Pfam PF00285
PRINTS PR00143
SUPFAM SSF48256
TIGRFAMs TIGR01793
PROSITE PS00480

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005759

mitochondrial matrix

PMID:21245132[1]

ECO:0000314

C

As seen on figure 6, localization of CS (citrate synthase) can be seen to be to the Mitochondrial Matrix. Citrate synthase, mitochondrial Mouse

complete
CACAO 12798

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75390

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75390

C

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75390

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201223
PomBase:SPAC6C3.04
RGD:620330
SGD:S000006205
UniProtKB:Q9I5E3

P

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201223
UniProtKB:O75390

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88529
PANTHER:PTN000201222
UniProtKB:O75390

C

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11756
FB:FBgn0261955
PANTHER:PTN000201223
PomBase:SPAC6C3.04
RGD:620330
SGD:S000000598
SGD:S000005284
SGD:S000006205
TAIR:locus:2050554
TAIR:locus:2052379
TAIR:locus:2098989
UniProtKB:O00098
UniProtKB:O75390
UniProtKB:Q9TEM3
dictyBase:DDB_G0267426

F

Seeded From UniProt

complete

enables

GO:0046912

transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

PMID:18729827[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006107

oxaloacetate metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620330

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006101

citrate metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620330

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006099

tricarboxylic acid cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620330

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006084

acetyl-CoA metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620330

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0005975

carbohydrate metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75390

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:25378300[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75390

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18614015[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14651853[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)|part_of:(EMAPA:16105)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:15809022[7]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8VHF5

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75390

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620330

C

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

PMID:15809022[7]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8VHF5

F

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O75390

F

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620330

F

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010109

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019810

P

Seeded From UniProt

complete

involved_in

GO:0006101

citrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010109

P

Seeded From UniProt

complete

enables

GO:0046912

transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002020
InterPro:IPR019810
InterPro:IPR036969

F

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.3.1

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0816
UniPathway:UPA00223

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Safdar, A et al. (2011) Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J. Biol. Chem. 286 10605-17 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Xu, F et al. (2008) Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria. Biochem. J. 416 15-26 PubMed GONUTS page
  4. ↑ Szczesny, B et al. (2014) Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Res. 42 13161-73 PubMed GONUTS page
  5. ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
  6. ↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
  7. ↑ 7.0 7.1 Chow, KM et al. (2005) Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Biochim. Biophys. Acta 1723 292-301 PubMed GONUTS page
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