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MOUSE:CELR3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Celsr3
Protein Name(s) Cadherin EGF LAG seven-pass G-type receptor 3
External Links
UniProt Q91ZI0
EMBL AF427498
AC168054
AF188752
CCDS CCDS23539.1
RefSeq NP_536685.2
UniGene Mm.39945
ProteinModelPortal Q91ZI0
IntAct Q91ZI0
STRING 10090.ENSMUSP00000024238
PhosphoSite Q91ZI0
MaxQB Q91ZI0
PaxDb Q91ZI0
PRIDE Q91ZI0
Ensembl ENSMUST00000024238
GeneID 107934
KEGG mmu:107934
UCSC uc009rrb.1
CTD 1951
MGI MGI:1858236
eggNOG NOG12793
GeneTree ENSGT00760000118805
HOGENOM HOG000231346
HOVERGEN HBG050887
InParanoid Q91ZI0
KO K04602
OMA HRTHNQL
OrthoDB EOG7BP81K
TreeFam TF323983
NextBio 359739
PRO PR:Q91ZI0
Proteomes UP000000589
Bgee Q91ZI0
Genevestigator Q91ZI0
GO GO:0016021
GO:0005886
GO:0005509
GO:0004930
GO:0007413
GO:0042384
GO:0007156
GO:0001764
GO:0007218
GO:0032880
Gene3D 2.60.120.200
2.60.40.60
InterPro IPR002126
IPR015919
IPR020894
IPR013320
IPR022624
IPR000742
IPR013032
IPR002049
IPR017981
IPR001879
IPR000832
IPR017983
IPR000203
IPR001791
Pfam PF00002
PF00028
PF12003
PF00008
PF01825
PF02793
PF00053
PF02210
PRINTS PR00205
PR00249
SMART SM00112
SM00181
SM00180
SM00303
SM00008
SM00282
SUPFAM SSF49313
SSF49899
PROSITE PS00010
PS00232
PS50268
PS00022
PS01186
PS50026
PS01248
PS50027
PS00650
PS50227
PS50261
PS50221
PS50025

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043524

negative regulation of neuron apoptosis

PMID:20631168[1]

ECO:0000315

P

Fig.4C

complete

involved_in

GO:0036515

serotonergic neuron axon guidance

PMID:21106844[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002028)

Seeded From UniProt

complete

involved_in

GO:1904938

planar cell polarity pathway involved in axon guidance

PMID:21106844[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036514

dopaminergic neuron axon guidance

PMID:21106844[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060271

cilium assembly

PMID:20473291[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1858235

P

occurs_in:(CL:0000065)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032880

regulation of protein localization

PMID:20473291[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1858235

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007413

axonal fasciculation

PMID:15778712[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3578665

P

occurs_in:(EMAPA:18206)|occurs_in:(EMAPA:35172)|occurs_in:(EMAPA:36031)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001932

regulation of protein phosphorylation

PMID:24305805[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001764

neuron migration

PMID:20631168[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3578665

P

  • occurs_in:(EMAPA:16916)
  • results_in_movement_of:(CL:0000100)

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR001879
InterPro:IPR017983
InterPro:IPR036445

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR002126
InterPro:IPR015919

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020894

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020894

P

Seeded From UniProt

complete

involved_in

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002126

P

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017983

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001879
InterPro:IPR002126
InterPro:IPR015919
InterPro:IPR036445

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017981

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Qu, Y et al. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J. Neurosci. 30 9392-401 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Fenstermaker, AG et al. (2010) Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J. Neurosci. 30 16053-64 PubMed GONUTS page
  3. ↑ 3.0 3.1 Tissir, F et al. (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat. Neurosci. 13 700-7 PubMed GONUTS page
  4. ↑ Tissir, F et al. (2005) Protocadherin Celsr3 is crucial in axonal tract development. Nat. Neurosci. 8 451-7 PubMed GONUTS page
  5. ↑ Onishi, K et al. (2013) Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J. Neurosci. 33 19071-85 PubMed GONUTS page
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