MOUSE:CELR2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Celsr2
Protein Name(s)	Cadherin EGF LAG seven-pass G-type receptor 2 Flamingo homolog
External Links
UniProt	Q9R0M0
EMBL	AB028499 AF031573 BC005499
UniGene	Mm.39728
ProteinModelPortal	Q9R0M0
IntAct	Q9R0M0
MINT	MINT-5202369
MEROPS	S63.009
PhosphoSite	Q9R0M0
MaxQB	Q9R0M0
PaxDb	Q9R0M0
PRIDE	Q9R0M0
MGI	MGI:1858235
eggNOG	NOG12793
HOGENOM	HOG000231346
HOVERGEN	HBG050887
InParanoid	Q9R0M0
PhylomeDB	Q9R0M0
ChiTaRS	Celsr2
PRO	PR:Q9R0M0
Proteomes	UP000000589
Genevestigator	Q9R0M0
GO	GO:0005737 GO:0016021 GO:0005886 GO:0005509 GO:0004930 GO:0033326 GO:0042384 GO:0003341 GO:0007156 GO:0021999 GO:0001764 GO:0007218 GO:0032880 GO:0006355 GO:0021591 GO:0016055
Gene3D	2.60.120.200 2.60.40.60
InterPro	IPR002126 IPR015919 IPR020894 IPR013320 IPR022624 IPR000742 IPR013032 IPR000152 IPR002049 IPR017981 IPR001879 IPR000832 IPR000203 IPR009030 IPR001791 IPR001368
Pfam	PF00002 PF00028 PF12003 PF00008 PF01825 PF00053 PF02210
PRINTS	PR00205 PR00249
SMART	SM00112 SM00181 SM00180 SM00303 SM00008 SM00282 SM00208
SUPFAM	SSF49313 SSF49899 SSF57184
PROSITE	PS00010 PS00232 PS50268 PS00022 PS01186 PS50026 PS01248 PS50027 PS50227 PS50261 PS50221 PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001764	neuron migration	PMID:20631168^[1]	ECO:0000315			P		Fig. 2C,G,K,O	complete
NOT	GO:0021594	rhombomere formation	PMID:20631168^[1]	ECO:0000315			P		Fig.6 The specification of r3-r6 and rhombomeric borders appeared normal in all mutants studied.	complete
involved_in	GO:0021999	neural plate anterior/posterior regionalization	PMID:12755329^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:12755329^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:15296717^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12755329^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16484285^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16484285^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:20473291^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1858236	P	occurs_in:(CL:0000065)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:20473291^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3604518	P	occurs_in:(CL:0000065)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69237	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033326	cerebrospinal fluid secretion	PMID:20473291^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1858236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	PMID:20473291^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1858236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	PMID:20473291^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022407	regulation of cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69237	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021591	ventricular system development	PMID:21746835^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5429210	P	results_in_development_of:(EMAPA:16914)\|results_in_development_of:(EMAPA:16900)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19474315^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q80Z62	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003341	cilium movement	PMID:20473291^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3604518	P	occurs_in:(CL:0000065)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:20631168^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3604518	P	occurs_in:(EMAPA:16916) results_in_movement_of:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR001879 InterPro:IPR036445	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR002126 InterPro:IPR015919	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001879 InterPro:IPR002126 InterPro:IPR015919 InterPro:IPR036445	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR017981	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qu, Y et al. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J. Neurosci. 30 9392-401 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Morgan, R et al. (2003) Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis. Int. J. Dev. Biol. 47 245-52 PubMed GONUTS page
↑ Shima, Y et al. (2004) Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev. Cell 7 205-16 PubMed GONUTS page
↑ ^4.0 ^4.1 Lahousse, SA et al. (2006) Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. Toxicol. Sci. 91 255-64 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Tissir, F et al. (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat. Neurosci. 13 700-7 PubMed GONUTS page
↑ Vogel, P et al. (2012) Congenital hydrocephalus in genetically engineered mice. Vet. Pathol. 49 166-81 PubMed GONUTS page
↑ Rezvani, K et al. (2009) UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. J. Neurosci. 29 6883-96 PubMed GONUTS page

[PMID:20631168-1] 1.0 ^1.1 ^1.2 Qu, Y et al. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J. Neurosci. 30 9392-401 PubMed GONUTS page

[PMID:12755329-2] 2.0 ^2.1 ^2.2 Morgan, R et al. (2003) Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis. Int. J. Dev. Biol. 47 245-52 PubMed GONUTS page

[PMID:15296717-3] Shima, Y et al. (2004) Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev. Cell 7 205-16 PubMed GONUTS page

[PMID:16484285-4] 4.0 ^4.1 Lahousse, SA et al. (2006) Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. Toxicol. Sci. 91 255-64 PubMed GONUTS page

[PMID:20473291-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Tissir, F et al. (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat. Neurosci. 13 700-7 PubMed GONUTS page

[PMID:21746835-6] Vogel, P et al. (2012) Congenital hydrocephalus in genetically engineered mice. Vet. Pathol. 49 166-81 PubMed GONUTS page

[PMID:19474315-7] Rezvani, K et al. (2009) UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. J. Neurosci. 29 6883-96 PubMed GONUTS page

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MOUSE:CELR2

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