MOUSE:CDC42

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cdc42
Protein Name(s)	Cell division control protein 42 homolog G25K GTP-binding protein
External Links
UniProt	P60766
EMBL	L11318 U37720 L78075 AK003098 AK051543 AK075567 AK144216 AK151087 AK151726 AK153564 AK154870 AK159470 AK166281 AK167195 AK167400 AK167609 AK168013 AK168076 AK168089 AK168276 AK168758 AK168820 AK169122 AK169232 AK169805 AL645468 AL645468 BC064792
CCDS	CCDS18816.1 CCDS57305.1
RefSeq	NP_001230698.1 NP_033991.1
UniGene	Mm.1022 Mm.447553
PDB	3EG5
PDBsum	3EG5
ProteinModelPortal	P60766
SMR	P60766
BioGrid	198627
DIP	DIP-32554N
IntAct	P60766
MINT	MINT-1602743
BindingDB	P60766
PhosphoSite	P60766
MaxQB	P60766
PaxDb	P60766
PRIDE	P60766
Ensembl	ENSMUST00000030417 ENSMUST00000051477
GeneID	12540
KEGG	mmu:12540
UCSC	uc008viw.3 uc008viy.2
CTD	998
MGI	MGI:106211
eggNOG	COG1100
GeneTree	ENSGT00760000118978
HOVERGEN	HBG009351
InParanoid	P60766
KO	K04393
OMA	KSDGERM
OrthoDB	EOG764747
PhylomeDB	P60766
TreeFam	TF101109
Reactome	REACT_198374 REACT_198649 REACT_203917 REACT_210090 REACT_248291 REACT_253889 REACT_257088 REACT_257656 REACT_258600 REACT_261451
EvolutionaryTrace	P60766
NextBio	281582
PRO	PR:P60766
Proteomes	UP000000589
Bgee	P60766
CleanEx	MM_CDC42
ExpressionAtlas	P60766
Genevestigator	P60766
GO	GO:0045177 GO:0071944 GO:0042995 GO:0005911 GO:0005737 GO:0036464 GO:0005829 GO:0070062 GO:0030175 GO:0000139 GO:0031256 GO:0016020 GO:0005815 GO:0030496 GO:0072686 GO:0043005 GO:0043025 GO:0030141 GO:0051233 GO:0005525 GO:0030742 GO:0003924 GO:0019901 GO:0090135 GO:0051017 GO:0034332 GO:0060070 GO:0003161 GO:0034613 GO:0036336 GO:0016197 GO:0048730 GO:0090136 GO:0060684 GO:0051683 GO:0035088 GO:0007163 GO:0046847 GO:0007030 GO:0006184 GO:0031069 GO:0060789 GO:0060047 GO:0031424 GO:0003334 GO:0035264 GO:0010629 GO:0031333 GO:0048664 GO:0007097 GO:0051647 GO:0072384 GO:0032467 GO:0045740 GO:0010628 GO:0071338 GO:0090316 GO:0046330 GO:0043410 GO:0048554 GO:0043525 GO:0033138 GO:0043552 GO:0001934 GO:0031274 GO:1900026 GO:0051835 GO:0051988 GO:0051489 GO:0007088 GO:0042176 GO:0043497 GO:0045859 GO:0051246 GO:0031647 GO:0007266 GO:0016337 GO:0002040 GO:0060661 GO:0021762
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR003578
Pfam	PF00071
PRINTS	PR00449
SMART	SM00174
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51420

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	PMID:23219958^[1]	ECO:0000315			P		Figure 1 -in the mice where Cdc42 was selectively deleted in respiratory epithelial cells the mice died at birth due to respiratory failure. While the control mice survived. This data then indicated that the loss of CDC42 decreased cell proliferation, impairing the growth of the fetal lung.	complete CACAO 7715
	GO:0010634	positive regulation of epithelial cell migration	PMID:24074261^[2]	ECO:0000315			P		Figure 5A- Cdc42 overexpression showed MECs were significantly more migratory.	complete CACAO 8797
	GO:0043410	positive regulation of MAPK cascade	PMID:24074261^[2]	ECO:0000315			P		Figure 6D- shows an increase in activated signal transducers along the MAPK pathway.	complete CACAO 8798
involved_in	GO:0007015	actin filament organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
involved_in	GO:0006911	phagocytosis, engulfment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
involved_in	GO:0045198	establishment of epithelial cell apical/basal polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
involved_in	GO:0034329	cell junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:22494997^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	PMID:23219958^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:25851601^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21048939^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5S006	F		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C		Seeded From UniProt	complete
involved_in	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
involved_in	GO:0051489	regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	P		Seeded From UniProt	complete
enables	GO:0030742	GTP-dependent protein binding	PMID:10954424^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z101	F		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60953	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 PANTHER:PTN001530052 WB:WBGene00000390 dictyBase:DDB_G0277869	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106211 MGI:MGI:1921984 PANTHER:PTN001530052 PomBase:SPAC110.03 RGD:621626 RGD:71043 SGD:S000004219 UniProtKB:P17081 UniProtKB:P60953 WB:WBGene00000390	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 MGI:MGI:106211 MGI:MGI:1920546 MGI:MGI:1921984 PANTHER:PTN001530052 UniProtKB:P60953 UniProtKB:Q15669 WB:WBGene00000390 dictyBase:DDB_G0279605	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039140 MGI:MGI:108446 MGI:MGI:97845 PANTHER:PTN000632671 RGD:619755 RGD:619921 RGD:71043 SGD:S000001380 TAIR:locus:2131606 TAIR:locus:2204380 UniProtKB:A0A1D8PDV5 UniProtKB:P15153 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:Q15669 UniProtKB:Q9SSX0 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0010341 FB:FBgn0014011 FB:FBgn0014020 MGI:MGI:106211 MGI:MGI:1096342 MGI:MGI:1916831 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN000632671 PomBase:SPAC110.03 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 PomBase:SPAC23C4.08 RGD:619755 RGD:619921 SGD:S000000046 SGD:S000001380 SGD:S000001763 SGD:S000004219 SGD:S000005034 SGD:S000005124 SGD:S000006369 TAIR:locus:2099232 TAIR:locus:2131606 UniProtKB:A0A1D8PCX9 UniProtKB:A0A1D8PH96 UniProtKB:P17081 UniProtKB:P60763 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:P84095 UniProtKB:Q5A904 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00003239 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
involved_in	GO:0099563	modification of synaptic structure	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000633069 RGD:71043	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000633069 UniProtKB:P60953	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000633069 UniProtKB:P60953	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106211 PANTHER:PTN001530052	C		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001530052 dictyBase:DDB_G0268622 dictyBase:DDB_G0279605	P		Seeded From UniProt	complete
involved_in	GO:0032488	Cdc42 protein signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632904 RGD:71043	P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1916831 MGI:MGI:1931551 PANTHER:PTN001530052 UniProtKB:P60953 UniProtKB:P84095 UniProtKB:Q9H4E5	P		Seeded From UniProt	complete
involved_in	GO:0030031	cell projection assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 PANTHER:PTN000632904	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 MGI:MGI:106211 PANTHER:PTN001530052 UniProtKB:P60953 dictyBase:DDB_G0268622 dictyBase:DDB_G0269176 dictyBase:DDB_G0277869 dictyBase:DDB_G0282365	F		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 MGI:MGI:1916831 MGI:MGI:1931551 MGI:MGI:1931553 PANTHER:PTN001530052 UniProtKB:Q7L0Q8 dictyBase:DDB_G0268622	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 FB:FBgn0014011 MGI:MGI:1931551 PANTHER:PTN000632671 RGD:619921 UniProtKB:I3LVS7 UniProtKB:P61586 UniProtKB:P84095	P		Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001530052 UniProtKB:G5EAY4 UniProtKB:Q4WWL5 WB:WBGene00000390 WB:WBGene00009059	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001530052 RGD:71043 UniProtKB:P60953	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106211 PANTHER:PTN000632904	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099563	modification of synaptic structure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099159	regulation of modification of postsynaptic structure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090316	positive regulation of intracellular protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090135	actin filament branching	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072384	organelle transport along microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:19796622^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071346	cellular response to interferon-gamma	PMID:19144319^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060047	heart contraction	PMID:21690310^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97350	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051835	positive regulation of synapse structural plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051683	establishment of Golgi localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051647	nucleus localization	PMID:16892058^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619134	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048664	neuron fate determination	PMID:16892058^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619134	P	results_in_determination_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046847	filopodium assembly	PMID:10699171^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	PMID:19144319^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:16892058^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:15728722^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043497	regulation of protein heterodimerization activity	PMID:19244314^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:19244314^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043085	positive regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:15728722^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036336	dendritic cell migration	PMID:22461490^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1921396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035088	establishment or maintenance of apical/basal cell polarity	PMID:16892058^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619134	P	occurs_in:(CL:0000710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034613	cellular protein localization	PMID:16621792^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034332	adherens junction organization	PMID:16892058^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619134	P	occurs_in:(CL:0000710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032488	Cdc42 protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	F		Seeded From UniProt	complete
part_of	GO:0031256	leading edge membrane	PMID:22461490^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007097	nuclear migration	PMID:16892058^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619134	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007097	nuclear migration	PMID:15882626^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007088	regulation of mitotic nuclear division	PMID:16892058^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3619134	P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007030	Golgi organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007015	actin filament organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006897	endocytosis	PMID:24792215^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000044)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:23793062^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25217619^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21828338^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21828338^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19796622^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000351)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15775979^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000312)	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:23620790^[24]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60953	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:18838382^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347084	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:18838382^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:15249579^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:10699171^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:12637522^[27]	ECO:0000247	sequence alignment evidence used in manual assertion	RefSeq:NP_001782	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003161	cardiac conduction system development	PMID:21690310^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97350	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002040	sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	P		Seeded From UniProt	complete
part_of	GO:0000322	storage vacuole	PMID:21828338^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71043	C		Seeded From UniProt	complete
involved_in	GO:0099563	modification of synaptic structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0099159	regulation of modification of postsynaptic structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	C		Seeded From UniProt	complete
involved_in	GO:0090316	positive regulation of intracellular protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0090135	actin filament branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0072384	organelle transport along microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0060661	submandibular salivary gland formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0051835	positive regulation of synapse structural plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0051683	establishment of Golgi localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0032488	Cdc42 protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	F		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	C		Seeded From UniProt	complete
involved_in	GO:0007030	Golgi organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	F		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	P		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CFN2 ensembl:ENSRNOP00000030928	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR037874	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR003578 InterPro:IPR005225	F		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003578	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:10954424^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016197	endosomal transport	PMID:10954424^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:10954424^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-5665684 Reactome:R-MMU-448947 Reactome:R-MMU-442572 Reactome:R-MMU-3928643	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007266	Rho protein signal transduction	PMID:10490598^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:10490598^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C		Seeded From UniProt	complete
part_of	GO:0031258	lamellipodium membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0292	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wan, H et al. (2013) CDC42 is required for structural patterning of the lung during development. Dev. Biol. 374 46-57 PubMed GONUTS page
↑ ^2.0 ^2.1 Bray, K et al. (2013) Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Res. 15 R91 PubMed GONUTS page
↑ Sakabe, I et al. (2012) Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. Immun Ageing 9 2 PubMed GONUTS page
↑ Jaudon, F et al. (2015) The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Mol. Biol. Cell 26 2112-27 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ Haebig, K et al. (2010) ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS ONE 5 e13762 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Johansson, A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell. Sci. 113 ( Pt 18) 3267-75 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 ^8.16 ^8.17 ^8.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ ^10.0 ^10.1 Trost, M et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30 143-54 PubMed GONUTS page
↑ ^11.0 ^11.1 Qian, L et al. (2011) Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J. Cell Biol. 193 1181-96 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Cappello, S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat. Neurosci. 9 1099-107 PubMed GONUTS page
↑ ^13.0 ^13.1 Prakash, SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum. Mol. Genet. 9 477-88 PubMed GONUTS page
↑ ^14.0 ^14.1 Aoki, K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol. Biol. Cell 16 2207-17 PubMed GONUTS page
↑ ^15.0 ^15.1 Oh, JE et al. (2009) Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. FASEB J. 23 2088-99 PubMed GONUTS page
↑ ^16.0 ^16.1 Harada, Y et al. (2012) DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood 119 4451-61 PubMed GONUTS page
↑ Sharma, M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J. Biol. Chem. 281 17140-9 PubMed GONUTS page
↑ Gomes, ER et al. (2005) Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell 121 451-63 PubMed GONUTS page
↑ Schultz, ML et al. (2014) CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events. PLoS ONE 9 e96647 PubMed GONUTS page
↑ Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
↑ Cariaga-Martínez, AE et al. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open 3 924-36 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Kepner, EM et al. (2011) Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion. Am. J. Physiol. Endocrinol. Metab. 301 E1072-80 PubMed GONUTS page
↑ Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page
↑ Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page
↑ ^25.0 ^25.1 Huber, C et al. (2008) FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J. Biol. Chem. 283 34002-12 PubMed GONUTS page
↑ Gakidis, MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell Biol. 166 273-82 PubMed GONUTS page
↑ Rossman, KL et al. (2003) Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J. Biol. Chem. 278 18393-400 PubMed GONUTS page
↑ ^28.0 ^28.1 Joberty, G et al. (1999) The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol. Cell. Biol. 19 6585-97 PubMed GONUTS page

[PMID:23219958-1] 1.0 ^1.1 Wan, H et al. (2013) CDC42 is required for structural patterning of the lung during development. Dev. Biol. 374 46-57 PubMed GONUTS page

[PMID:24074261-2] 2.0 ^2.1 Bray, K et al. (2013) Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Res. 15 R91 PubMed GONUTS page

[PMID:22494997-3] Sakabe, I et al. (2012) Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. Immun Ageing 9 2 PubMed GONUTS page

[PMID:25851601-4] Jaudon, F et al. (2015) The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Mol. Biol. Cell 26 2112-27 PubMed GONUTS page

[PMID:17634366-5] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:21048939-6] Haebig, K et al. (2010) ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS ONE 5 e13762 PubMed GONUTS page

[PMID:10954424-7] 7.0 ^7.1 ^7.2 ^7.3 Johansson, A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell. Sci. 113 ( Pt 18) 3267-75 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 ^8.16 ^8.17 ^8.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19796622-9] 9.0 ^9.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:19144319-10] 10.0 ^10.1 Trost, M et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30 143-54 PubMed GONUTS page

[PMID:21690310-11] 11.0 ^11.1 Qian, L et al. (2011) Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J. Cell Biol. 193 1181-96 PubMed GONUTS page

[PMID:16892058-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Cappello, S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat. Neurosci. 9 1099-107 PubMed GONUTS page

[PMID:10699171-13] 13.0 ^13.1 Prakash, SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum. Mol. Genet. 9 477-88 PubMed GONUTS page

[PMID:15728722-14] 14.0 ^14.1 Aoki, K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol. Biol. Cell 16 2207-17 PubMed GONUTS page

[PMID:19244314-15] 15.0 ^15.1 Oh, JE et al. (2009) Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. FASEB J. 23 2088-99 PubMed GONUTS page

[PMID:22461490-16] 16.0 ^16.1 Harada, Y et al. (2012) DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood 119 4451-61 PubMed GONUTS page

[PMID:16621792-17] Sharma, M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J. Biol. Chem. 281 17140-9 PubMed GONUTS page

[PMID:15882626-18] Gomes, ER et al. (2005) Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell 121 451-63 PubMed GONUTS page

[PMID:24792215-19] Schultz, ML et al. (2014) CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events. PLoS ONE 9 e96647 PubMed GONUTS page

[PMID:23793062-20] Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page

[PMID:25217619-21] Cariaga-Martínez, AE et al. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open 3 924-36 PubMed GONUTS page

[PMID:21828338-22] 22.0 ^22.1 ^22.2 Kepner, EM et al. (2011) Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion. Am. J. Physiol. Endocrinol. Metab. 301 E1072-80 PubMed GONUTS page

[PMID:15775979-23] Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page

[PMID:23620790-24] Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page

[PMID:18838382-25] 25.0 ^25.1 Huber, C et al. (2008) FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J. Biol. Chem. 283 34002-12 PubMed GONUTS page

[PMID:15249579-26] Gakidis, MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell Biol. 166 273-82 PubMed GONUTS page

[PMID:12637522-27] Rossman, KL et al. (2003) Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J. Biol. Chem. 278 18393-400 PubMed GONUTS page

[PMID:10490598-28] 28.0 ^28.1 Joberty, G et al. (1999) The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol. Cell. Biol. 19 6585-97 PubMed GONUTS page

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