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PMID:24074261
| Citation |
Bray, K, Gillette, M, Young, J, Loughran, E, Hwang, M, Sears, JC and Vargo-Gogola, T (2013) Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Res. 15:R91 |
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| Abstract |
The Rho GTPase Cdc42 is overexpressed and hyperactivated in breast tumors compared to normal breast tissue. Cdc42 regulates key processes that are critical for mammary gland morphogenesis and become disrupted during the development, progression, and metastasis of breast cancer. However, the contribution of Cdc42 to normal and neoplastic mammary gland development in vivo remains poorly understood. We were therefore interested in investigating the effects of Cdc42 overexpression on mammary gland morphogenesis as a first step towards understanding how its overexpression may contribute to mammary tumorigenesis. |
| Links |
PubMed Online version:10.1186/bcr3487 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0010634: positive regulation of epithelial cell migration |
ECO:0000315: |
P |
Figure 5A- Cdc42 overexpression showed MECs were significantly more migratory. |
complete | ||||
| GO:0043410: positive regulation of MAPK cascade |
ECO:0000315: |
P |
Figure 6D- shows an increase in activated signal transducers along the MAPK pathway. |
complete | ||||
See also
References
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