MOUSE:CALCR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Calcr
Protein Name(s)	Calcitonin receptor CT-R
External Links
UniProt	Q60755
EMBL	U18542 AK039161 AK162391 AK133983 AK138275 AC066688 AC161368 CH466533 CH466533 BC119232 BC119272
CCDS	CCDS39416.1 CCDS39417.1
PIR	I49154
RefSeq	NP_001036190.1 NP_031614.2 XP_006505035.1 XP_006505036.1
UniGene	Mm.4642
ProteinModelPortal	Q60755
SMR	Q60755
GuidetoPHARMACOLOGY	43
PhosphoSite	Q60755
PRIDE	Q60755
Ensembl	ENSMUST00000075644 ENSMUST00000115622 ENSMUST00000168592 ENSMUST00000170266 ENSMUST00000171613
GeneID	12311
KEGG	mmu:12311
UCSC	uc009ave.1 uc009avf.1
CTD	799
MGI	MGI:101950
eggNOG	NOG255868
GeneTree	ENSGT00760000118800
HOVERGEN	HBG102129
InParanoid	Q60755
KO	K04576
OMA	ICKILHF
PhylomeDB	Q60755
TreeFam	TF315710
Reactome	REACT_242871 REACT_255862
NextBio	280862
PRO	PR:Q60755
Proteomes	UP000000589
CleanEx	MM_CALCR
ExpressionAtlas	Q60755
Genevestigator	Q60755
GO	GO:0001669 GO:0030424 GO:0005929 GO:0016021 GO:0043025 GO:0005886 GO:0032841 GO:0004948 GO:0007189 GO:0030279 GO:0030316 GO:0007204 GO:0043488
InterPro	IPR003287 IPR017981 IPR001688 IPR001879 IPR000832 IPR017983
Pfam	PF00002 PF02793
PRINTS	PR00361 PR01350 PR00249
SMART	SM00008
PROSITE	PS00649 PS00650 PS50227 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
contributes_to	GO:0097643	amylin receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001381030 UniProtKB:P30988	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001381030 RGD:621001	C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101950 PANTHER:PTN001381030 UniProtKB:P30988	P		Seeded From UniProt	complete
enables	GO:0004948	calcitonin receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101950 PANTHER:PTN001381030 RGD:621001 UniProtKB:P25117 UniProtKB:P30988	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905665	positive regulation of calcium ion import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904645	response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
part_of	GO:0150058	amylin receptor complex 3	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	C		Seeded From UniProt	complete
part_of	GO:0150057	amylin receptor complex 2	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	C		Seeded From UniProt	complete
part_of	GO:0150056	amylin receptor complex 1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097647	amylin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
enables	GO:0097643	amylin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	F		Seeded From UniProt	complete
contributes_to	GO:0097643	amylin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051384	response to glucocorticoid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045762	positive regulation of adenylate cyclase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043488	regulation of mRNA stability	PMID:9002981^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:101950)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621001	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621001	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038041	cross-receptor inhibition within G protein-coupled receptor heterodimer	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
enables	GO:0032841	calcitonin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621001	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621001	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:7664679^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32760) results_in_acquisition_of_features_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030279	negative regulation of ossification	PMID:14970190^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3038975	P	regulates_o_occurs_in:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010739	positive regulation of protein kinase A signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:9753683^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:7988453^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621001	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:12704735^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
enables	GO:0004948	calcitonin receptor activity	PMID:7988453^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004948	calcitonin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	F		Seeded From UniProt	complete
enables	GO:0004948	calcitonin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621001	F		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	PMID:12704735^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
enables	GO:0001635	calcitonin gene-related peptide receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P30988	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR001879 InterPro:IPR017983 InterPro:IPR036445	F		Seeded From UniProt	complete
enables	GO:0004948	calcitonin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001688 InterPro:IPR003287	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR003287 InterPro:IPR017983	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001688 InterPro:IPR001879 InterPro:IPR003287 InterPro:IPR036445	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR017981	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Wada, S et al. (1997) Regulation by calcitonin and glucocorticoids of calcitonin receptor gene expression in mouse osteoclasts. Endocrinology 138 521-9 PubMed GONUTS page
↑ Lee, SK et al. (1995) Expression of the calcitonin receptor in bone marrow cell cultures and in bone: a specific marker of the differentiated osteoclast that is regulated by calcitonin. Endocrinology 136 4572-81 PubMed GONUTS page
↑ Dacquin, R et al. (2004) Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J. Cell Biol. 164 509-14 PubMed GONUTS page
↑ Wang, J et al. (1998) Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst differentiation by calcitonin. Development 125 4293-302 PubMed GONUTS page
↑ ^6.0 ^6.1 Yamin, M et al. (1994) Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology 135 2635-43 PubMed GONUTS page
↑ ^7.0 ^7.1 Adeoya-Osiguwa, SA & Fraser, LR (2003) Calcitonin acts as a first messenger to regulate adenylyl cyclase/cAMP and mammalian sperm function. Mol. Reprod. Dev. 65 228-36 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9002981-2] Wada, S et al. (1997) Regulation by calcitonin and glucocorticoids of calcitonin receptor gene expression in mouse osteoclasts. Endocrinology 138 521-9 PubMed GONUTS page

[PMID:7664679-3] Lee, SK et al. (1995) Expression of the calcitonin receptor in bone marrow cell cultures and in bone: a specific marker of the differentiated osteoclast that is regulated by calcitonin. Endocrinology 136 4572-81 PubMed GONUTS page

[PMID:14970190-4] Dacquin, R et al. (2004) Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J. Cell Biol. 164 509-14 PubMed GONUTS page

[PMID:9753683-5] Wang, J et al. (1998) Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst differentiation by calcitonin. Development 125 4293-302 PubMed GONUTS page

[PMID:7988453-6] 6.0 ^6.1 Yamin, M et al. (1994) Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology 135 2635-43 PubMed GONUTS page

[PMID:12704735-7] 7.0 ^7.1 Adeoya-Osiguwa, SA & Fraser, LR (2003) Calcitonin acts as a first messenger to regulate adenylyl cyclase/cAMP and mammalian sperm function. Mol. Reprod. Dev. 65 228-36 PubMed GONUTS page

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MOUSE:CALCR

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Annotations

Notes

References

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