MOUSE:CAD23

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cdh23
Protein Name(s)	Cadherin-23 Otocadherin
External Links
UniProt	Q99PF4
EMBL	AF308939 AY026062 AK016365 AC079082 AC079818 AC079819 AC153517
RefSeq	NP_075859.2
UniGene	Mm.440327
PDB	2WBX 2WCP 2WD0 2WHV 3MVS 4APX 4AQ8 4AQA 4AQE 4AXW
PDBsum	2WBX 2WCP 2WD0 2WHV 3MVS 4APX 4AQ8 4AQA 4AQE 4AXW
ProteinModelPortal	Q99PF4
SMR	Q99PF4
BioGrid	204475
DIP	DIP-42152N
IntAct	Q99PF4
MINT	MINT-1895823
PhosphoSite	Q99PF4
PaxDb	Q99PF4
PRIDE	Q99PF4
Ensembl	ENSMUST00000105461 ENSMUST00000105463
GeneID	22295
KEGG	mmu:22295
UCSC	uc007fev.2
CTD	64072
MGI	MGI:1890219
eggNOG	NOG12793
GeneTree	ENSGT00760000118805
HOGENOM	HOG000139588
HOVERGEN	HBG050768
InParanoid	Q99PF4
KO	K06813
OMA	DVTEGQP
TreeFam	TF316403
EvolutionaryTrace	Q99PF4
NextBio	302447
PRO	PR:Q99PF4
Proteomes	UP000000589
Bgee	Q99PF4
ExpressionAtlas	Q99PF4
Genevestigator	Q99PF4
GO	GO:0005813 GO:0016021 GO:0060091 GO:0001917 GO:0005886 GO:0032420 GO:0032426 GO:0045202 GO:0005509 GO:0042491 GO:0060088 GO:0016339 GO:0007155 GO:0007156 GO:0048839 GO:0042472 GO:0007626 GO:0048563 GO:0050953 GO:0007605
Gene3D	2.60.40.60
InterPro	IPR002126 IPR015919 IPR020894
Pfam	PF00028
PRINTS	PR00205
SMART	SM00112
SUPFAM	SSF49313
PROSITE	PS00232 PS50268

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0032420	stereocilium	PMID:12485990^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098684	photoreceptor ribbon synapse	PMID:19756182^[2]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098684	photoreceptor ribbon synapse	PMID:19756182^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098683	cochlear hair cell ribbon synapse	PMID:19756182^[2]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098683	cochlear hair cell ribbon synapse	PMID:19756182^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:19756182^[2]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		C	part_of:(GO:0098684) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:19756182^[2]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		C	part_of:(GO:0098683) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:19756182^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098684) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:19756182^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098683) part_of:(UBERON:0000061)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060122	inner ear receptor cell stereocilium organization	PMID:18339676^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154548	P	occurs_in:(EMAPA:19151)	Seeded From UniProt	complete
part_of	GO:0060091	kinocilium	PMID:15882574^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17597) part_of:(CL:0000202)\|part_of:(EMAPA:17597) part_of:(CL:0000202)\|part_of:(EMAPA:17597) part_of:(CL:0000202)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:15537665^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1891428	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000601)\|occurs_in:(EMAPA:19151) occurs_in:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:9039475^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856681	P	occurs_in:(EMAPA:17815) occurs_in:(CL:0000609)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:8790740^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856681	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000601)\|occurs_in:(EMAPA:19151) occurs_in:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:7610888^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856681	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000601)\|occurs_in:(EMAPA:19151) occurs_in:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:23217710^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154548	P	occurs_in:(EMAPA:17598) occurs_in:(CL:0000202)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:17050716^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154548	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000589)\|occurs_in:(EMAPA:19151) occurs_in:(CL:0000601)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:12121736^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856228	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:11322776^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154549	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000601)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:11138008^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154548	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000589)\|occurs_in:(EMAPA:19151) occurs_in:(CL:0000601)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H251	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050957	equilibrioception	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H251	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050953	sensory perception of light stimulus	PMID:14609561^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856228	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050953	sensory perception of light stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H251	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:8790740^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856681	P	results_in_development_of:(EMAPA:19151)\|results_in_development_of:(EMAPA:35827)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:14759567^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3028349	P	results_in_development_of:(EMAPA:19151)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:13336002^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856228	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048563	post-embryonic animal organ morphogenesis	PMID:13336002^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856228	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619760	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045494	photoreceptor cell maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H251	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14578428^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619760	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042491	inner ear auditory receptor cell differentiation	PMID:12121736^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856228	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:7610888^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:15925194^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665714	P		Seeded From UniProt	complete
part_of	GO:0032426	stereocilium tip	PMID:24920589^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000601) part_of:(EMAPA:17597)	Seeded From UniProt	complete
part_of	GO:0032426	stereocilium tip	PMID:17050716^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17293) part_of:(CL:0000609)\|part_of:(EMAPA:17290) part_of:(CL:0000609)	Seeded From UniProt	complete
part_of	GO:0032426	stereocilium tip	PMID:12485990^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17286) part_of:(CL:0000609)	Seeded From UniProt	complete
part_of	GO:0032420	stereocilium	PMID:17050716^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17293) part_of:(CL:0000609)\|part_of:(EMAPA:17290) part_of:(CL:0000609)	Seeded From UniProt	complete
part_of	GO:0032420	stereocilium	PMID:16481439^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19151) part_of:(CL:0000601)\|part_of:(EMAPA:19151) part_of:(CL:0000589)	Seeded From UniProt	complete
part_of	GO:0032420	stereocilium	PMID:15882574^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17597) part_of:(CL:0000601)\|part_of:(EMAPA:17597) part_of:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:11138009^[21]	ECO:0000250	sequence similarity evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:16962269^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154547 MGI:MGI:2154548	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:11386759^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856412	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:10452381^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856681	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:9325047^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:105368	P	has_participant:(EMAPA:32678)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:15537665^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1891428	P	has_participant:(EMAPA:36002)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:9447922^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3028349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:17329413^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3708379	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:15925194^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665714	P	has_participant:(EMAPA:36002)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:15820310^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3028349	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:14759567^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3028349	P	has_participant:(EMAPA:36002)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:13336002^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856228	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:12121736^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856228	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:11322776^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154549	P	has_participant:(EMAPA:36002)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:11138008^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154548	P	has_participant:(EMAPA:36002)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:10452381^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856681	P	has_participant:(EMAPA:36002)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H251	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H251	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:15882574^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17597) part_of:(CL:0000202)	Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	PMID:14578428^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126 InterPro:IPR015919	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126	P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033030	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033030	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126 InterPro:IPR015919	C		Seeded From UniProt	complete
part_of	GO:0032420	stereocilium	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033030	C		Seeded From UniProt	complete
involved_in	GO:0060122	inner ear receptor cell stereocilium organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:11138009^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1009	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Boëda, B et al. (2002) Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J. 21 6689-99 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Lagziel, A et al. (2009) Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D. Mol. Vis. 15 1843-57 PubMed GONUTS page
↑ Lefèvre, G et al. (2008) A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth. Development 135 1427-37 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Lagziel, A et al. (2005) Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development. Dev. Biol. 280 295-306 PubMed GONUTS page
↑ ^5.0 ^5.1 Zheng, QY et al. (2005) Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans. Hum. Mol. Genet. 14 103-11 PubMed GONUTS page
↑ Moriyama, K et al. (1997) Degenerative hairlets on the vestibular sensory cells in mutant bustling (BUS/Idr) mice. Acta Otolaryngol. 117 20-4 PubMed GONUTS page
↑ ^7.0 ^7.1 Yonezawa, S et al. (1996) Cochlear histopathology of the mutant bustling mouse, BUS/Idr. Acta Otolaryngol. 116 409-16 PubMed GONUTS page
↑ ^8.0 ^8.1 Otani, H et al. (1995) Vestibulocochlear defects and effects of deuterium oxide in mutant bustling (BUS) mice. Acta Otolaryngol Suppl 519 286-93 PubMed GONUTS page
↑ Xiong, W et al. (2012) TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell 151 1283-95 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Phillips, KR et al. (2006) Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice. J. Neurosci. 26 10777-88 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Holme, RH & Steel, KP (2002) Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice. Hear. Res. 169 13-23 PubMed GONUTS page
↑ ^12.0 ^12.1 Wada, T et al. (2001) A point mutation in a cadherin gene, Cdh23, causes deafness in a novel mutant, Waltzer mouse niigata. Biochem. Biophys. Res. Commun. 283 113-7 PubMed GONUTS page
↑ ^13.0 ^13.1 Di Palma, F et al. (2001) Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nat. Genet. 27 103-7 PubMed GONUTS page
↑ Libby, RT et al. (2003) Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration. Exp. Eye Res. 77 731-9 PubMed GONUTS page
↑ ^15.0 ^15.1 Keithley, EM et al. (2004) Age-related hearing loss and the ahl locus in mice. Hear. Res. 188 21-8 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 DEOL, MS (1956) The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse. Proc. R. Soc. Lond., B, Biol. Sci. 145 206-13 PubMed GONUTS page
↑ ^17.0 ^17.1 Reiners, J et al. (2003) Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells. Invest. Ophthalmol. Vis. Sci. 44 5006-15 PubMed GONUTS page
↑ ^18.0 ^18.1 Harding, GW et al. (2005) The effect of an age-related hearing loss gene (Ahl) on noise-induced hearing loss and cochlear damage from low-frequency noise. Hear. Res. 204 90-100 PubMed GONUTS page
↑ Kamiya, K et al. (2014) An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells. Proc. Natl. Acad. Sci. U.S.A. 111 9307-12 PubMed GONUTS page
↑ Senften, M et al. (2006) Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J. Neurosci. 26 2060-71 PubMed GONUTS page
↑ ^21.0 ^21.1 Bolz, H et al. (2001) Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D. Nat. Genet. 27 108-12 PubMed GONUTS page
↑ Calderon, A et al. (2006) Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear. Res. 221 44-58 PubMed GONUTS page
↑ Wilson, SM et al. (2001) Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice. Genomics 74 228-33 PubMed GONUTS page
↑ ^24.0 ^24.1 Yonezawa, S et al. (1999) Chromosomal localization of a gene responsible for vestibulocochlear defects of BUS/Idr mice: identification as an allele of waltzer. Hear. Res. 134 116-22 PubMed GONUTS page
↑ Noben-Trauth, K et al. (1997) mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44 266-72 PubMed GONUTS page
↑ Johnson, KR et al. (1997) A major gene affecting age-related hearing loss in C57BL/6J mice. Hear. Res. 114 83-92 PubMed GONUTS page
↑ Schwander, M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J. Neurosci. 27 2163-75 PubMed GONUTS page
↑ Johnson, KR et al. (2005) The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85 582-90 PubMed GONUTS page

[PMID:12485990-1] 1.0 ^1.1 Boëda, B et al. (2002) Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J. 21 6689-99 PubMed GONUTS page

[PMID:19756182-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Lagziel, A et al. (2009) Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D. Mol. Vis. 15 1843-57 PubMed GONUTS page

[PMID:18339676-3] Lefèvre, G et al. (2008) A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth. Development 135 1427-37 PubMed GONUTS page

[PMID:15882574-4] 4.0 ^4.1 ^4.2 Lagziel, A et al. (2005) Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development. Dev. Biol. 280 295-306 PubMed GONUTS page

[PMID:15537665-5] 5.0 ^5.1 Zheng, QY et al. (2005) Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans. Hum. Mol. Genet. 14 103-11 PubMed GONUTS page

[PMID:9039475-6] Moriyama, K et al. (1997) Degenerative hairlets on the vestibular sensory cells in mutant bustling (BUS/Idr) mice. Acta Otolaryngol. 117 20-4 PubMed GONUTS page

[PMID:8790740-7] 7.0 ^7.1 Yonezawa, S et al. (1996) Cochlear histopathology of the mutant bustling mouse, BUS/Idr. Acta Otolaryngol. 116 409-16 PubMed GONUTS page

[PMID:7610888-8] 8.0 ^8.1 Otani, H et al. (1995) Vestibulocochlear defects and effects of deuterium oxide in mutant bustling (BUS) mice. Acta Otolaryngol Suppl 519 286-93 PubMed GONUTS page

[PMID:23217710-9] Xiong, W et al. (2012) TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell 151 1283-95 PubMed GONUTS page

[PMID:17050716-10] 10.0 ^10.1 ^10.2 Phillips, KR et al. (2006) Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice. J. Neurosci. 26 10777-88 PubMed GONUTS page

[PMID:12121736-11] 11.0 ^11.1 ^11.2 Holme, RH & Steel, KP (2002) Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice. Hear. Res. 169 13-23 PubMed GONUTS page

[PMID:11322776-12] 12.0 ^12.1 Wada, T et al. (2001) A point mutation in a cadherin gene, Cdh23, causes deafness in a novel mutant, Waltzer mouse niigata. Biochem. Biophys. Res. Commun. 283 113-7 PubMed GONUTS page

[PMID:11138008-13] 13.0 ^13.1 Di Palma, F et al. (2001) Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nat. Genet. 27 103-7 PubMed GONUTS page

[PMID:14609561-14] Libby, RT et al. (2003) Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration. Exp. Eye Res. 77 731-9 PubMed GONUTS page

[PMID:14759567-15] 15.0 ^15.1 Keithley, EM et al. (2004) Age-related hearing loss and the ahl locus in mice. Hear. Res. 188 21-8 PubMed GONUTS page

[PMID:13336002-16] 16.0 ^16.1 ^16.2 DEOL, MS (1956) The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse. Proc. R. Soc. Lond., B, Biol. Sci. 145 206-13 PubMed GONUTS page

[PMID:14578428-17] 17.0 ^17.1 Reiners, J et al. (2003) Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells. Invest. Ophthalmol. Vis. Sci. 44 5006-15 PubMed GONUTS page

[PMID:15925194-18] 18.0 ^18.1 Harding, GW et al. (2005) The effect of an age-related hearing loss gene (Ahl) on noise-induced hearing loss and cochlear damage from low-frequency noise. Hear. Res. 204 90-100 PubMed GONUTS page

[PMID:24920589-19] Kamiya, K et al. (2014) An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells. Proc. Natl. Acad. Sci. U.S.A. 111 9307-12 PubMed GONUTS page

[PMID:16481439-20] Senften, M et al. (2006) Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J. Neurosci. 26 2060-71 PubMed GONUTS page

[PMID:11138009-21] 21.0 ^21.1 Bolz, H et al. (2001) Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D. Nat. Genet. 27 108-12 PubMed GONUTS page

[PMID:16962269-22] Calderon, A et al. (2006) Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear. Res. 221 44-58 PubMed GONUTS page

[PMID:11386759-23] Wilson, SM et al. (2001) Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice. Genomics 74 228-33 PubMed GONUTS page

[PMID:10452381-24] 24.0 ^24.1 Yonezawa, S et al. (1999) Chromosomal localization of a gene responsible for vestibulocochlear defects of BUS/Idr mice: identification as an allele of waltzer. Hear. Res. 134 116-22 PubMed GONUTS page

[PMID:9325047-25] Noben-Trauth, K et al. (1997) mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44 266-72 PubMed GONUTS page

[PMID:9447922-26] Johnson, KR et al. (1997) A major gene affecting age-related hearing loss in C57BL/6J mice. Hear. Res. 114 83-92 PubMed GONUTS page

[PMID:17329413-27] Schwander, M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J. Neurosci. 27 2163-75 PubMed GONUTS page

[PMID:15820310-28] Johnson, KR et al. (2005) The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85 582-90 PubMed GONUTS page

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