MOUSE:BOP1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bop1 (synonyms: Kiaa0124)
Protein Name(s)	Ribosome biogenesis protein BOP1 (ECO:0000255 with HAMAP-Rule:MF_03027) Block of proliferation 1 protein (ECO:0000255 with HAMAP-Rule:MF_03027)
External Links
UniProt	P97452
EMBL	U77415 AK129058 AK079627 AK167110 BC012693 AF061503
CCDS	CCDS27570.1
RefSeq	NP_038509.1
UniGene	Mm.4283
ProteinModelPortal	P97452
SMR	P97452
BioGrid	198380
IntAct	P97452
MINT	MINT-4089312
PhosphoSite	P97452
MaxQB	P97452
PaxDb	P97452
PRIDE	P97452
Ensembl	ENSMUST00000023217
GeneID	12181
KEGG	mmu:12181
UCSC	uc007wkf.1
CTD	23246
MGI	MGI:1334460
eggNOG	COG2319
GeneTree	ENSGT00390000018422
HOGENOM	HOG000029368
HOVERGEN	HBG008113
InParanoid	P97452
KO	K14824
OMA	HEAKRIM
OrthoDB	EOG7MPRD9
PhylomeDB	P97452
TreeFam	TF300437
ChiTaRS	Bop1
NextBio	280569
PRO	PR:P97452
Proteomes	UP000000589
Bgee	P97452
CleanEx	MM_BOP1
Genevestigator	P97452
GO	GO:0005730 GO:0005654 GO:0070545 GO:0030687 GO:0030529 GO:0044822 GO:0043021 GO:0008283 GO:0000448 GO:0000463 GO:0051726 GO:0042273 GO:0006364
Gene3D	2.130.10.10
HAMAP	MF_03027
InterPro	IPR028598 IPR012953 IPR015943 IPR001680 IPR019775 IPR017986
Pfam	PF08145 PF00400
SMART	SM01035 SM00320
SUPFAM	SSF50978
PROSITE	PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008283	cell proliferation	PMID:17353269^[1]	ECO:0000315			P	Figure 1A Lanes 3 and 7 illustrates over expression of bop1 cells showed reductions in cell count.	complete CACAO 4583
involved_in	GO:0008283	cell population proliferation	PMID:17353269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070545	PeBoW complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14137	C	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14137	P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:17353269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:17353269^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14137	P	Seeded From UniProt	complete
involved_in	GO:0000448	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	PMID:17353269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070545	PeBoW complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000426773 SGD:S000004652 UniProtKB:Q14137	C	Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1334460 PANTHER:PTN000426773	F	Seeded From UniProt	complete
part_of	GO:0030687	preribosome, large subunit precursor	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000426773 SGD:S000004652	C	Seeded From UniProt	complete
involved_in	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000426773 UniProtKB:Q14137	P	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:18809582^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901796	regulation of signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	P	Seeded From UniProt	complete
part_of	GO:0070545	PeBoW complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	P	Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	PMID:10891491^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042273	ribosomal large subunit biogenesis	PMID:10891491^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006364	rRNA processing	PMID:15225545^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890613	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006364	rRNA processing	PMID:10891491^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000027	ribosomal large subunit assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14137	P	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	C	Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	P	Seeded From UniProt	complete
part_of	GO:0070545	PeBoW complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	C	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	C	Seeded From UniProt	complete
involved_in	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	P	Seeded From UniProt	complete
involved_in	GO:0000027	ribosomal large subunit assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14137 ensembl:ENSP00000455106	P	Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012953	P	Seeded From UniProt	complete
involved_in	GO:0042254	ribosome biogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028598	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107534	C	Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107534	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107534	C	Seeded From UniProt	complete
part_of	GO:0030687	preribosome, large subunit precursor	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107534	C	Seeded From UniProt	complete
involved_in	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107534	P	Seeded From UniProt	complete
involved_in	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107534	P	Seeded From UniProt	complete
involved_in	GO:0042273	ribosomal large subunit biogenesis	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107534	P	Seeded From UniProt	complete
involved_in	GO:0006364	rRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0698	P	Seeded From UniProt	complete
involved_in	GO:0042254	ribosome biogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0690	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Rohrmoser, M et al. (2007) Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol. Cell. Biol. 27 3682-94 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Strezoska, Z et al. (2000) Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. Mol. Cell. Biol. 20 5516-28 PubMed GONUTS page
↑ Lapik, YR et al. (2004) Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol. Cell 15 17-29 PubMed GONUTS page

[PMID:17353269-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Rohrmoser, M et al. (2007) Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol. Cell. Biol. 27 3682-94 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18809582-3] Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page

[PMID:10891491-4] 4.0 ^4.1 ^4.2 Strezoska, Z et al. (2000) Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. Mol. Cell. Biol. 20 5516-28 PubMed GONUTS page

[PMID:15225545-5] Lapik, YR et al. (2004) Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol. Cell 15 17-29 PubMed GONUTS page

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MOUSE:BOP1

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