MOUSE:BCCIP

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bccip
Protein Name(s)	BRCA2 and CDKN1A-interacting protein
External Links
UniProt	Q9CWI3
EMBL	AK003666 AK010684 BC048465
CCDS	CCDS21935.1
RefSeq	NP_079668.2
UniGene	Mm.389983
ProteinModelPortal	Q9CWI3
IntAct	Q9CWI3
MINT	MINT-4615024
STRING	10090.ENSMUSP00000033282
PhosphoSite	Q9CWI3
MaxQB	Q9CWI3
PaxDb	Q9CWI3
PRIDE	Q9CWI3
Ensembl	ENSMUST00000033282
GeneID	66165
KEGG	mmu:66165
UCSC	uc009kdi.1
CTD	56647
MGI	MGI:1913415
eggNOG	NOG310413
GeneTree	ENSGT00390000000696
HOGENOM	HOG000047210
HOVERGEN	HBG054955
InParanoid	Q9CWI3
KO	K15262
OMA	GSVICQC
OrthoDB	EOG7992RJ
PhylomeDB	Q9CWI3
TreeFam	TF320301
ChiTaRS	Bccip
NextBio	320826
PRO	PR:Q9CWI3
Proteomes	UP000000589
Bgee	Q9CWI3
CleanEx	MM_BCCIP
Genevestigator	Q9CWI3
GO	GO:0019908 GO:0019207 GO:0044822 GO:0007049 GO:0006281 GO:0061101 GO:0000079
InterPro	IPR025602
PANTHER	PTHR13261
Pfam	PF13862
PIRSF	PIRSF028983

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006974	cellular response to DNA damage stimulus	PMID:21966279^[1]	ECO:0000315			P	Figure 7. BCCIP Knockdown cells exhibit greater growth inhibition by irradiation compared to control.	complete CACAO 3994
part_of	GO:0005814	centriole	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9P287	C	Seeded From UniProt	complete
involved_in	GO:0034453	microtubule anchoring	PMID:28394342^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:28394342^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:28394342^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	PMID:28394342^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:28394342^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21966279^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913415 PANTHER:PTN000327451 UniProtKB:Q9P287	C	Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000327451 UniProtKB:Q9P287	P	Seeded From UniProt	complete
involved_in	GO:0034453	microtubule anchoring	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913415 PANTHER:PTN000327451 UniProtKB:Q9P287	P	Seeded From UniProt	complete
enables	GO:0019207	kinase regulator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000327451 UniProtKB:Q9P287	F	Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000327451 UniProtKB:Q9P287	F	Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913415 PANTHER:PTN000327451 UniProtKB:Q9P287	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913415 PANTHER:PTN000327451	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1913415 PANTHER:PTN000327451 UniProtKB:Q9P287	C	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000327451 UniProtKB:Q9P287	P	Seeded From UniProt	complete
involved_in	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000327451 UniProtKB:Q9P287	P	Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090307	mitotic spindle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061101	neuroendocrine cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034453	microtubule anchoring	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	P	Seeded From UniProt	complete
part_of	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	C	Seeded From UniProt	complete
enables	GO:0019207	kinase regulator activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	F	Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007052	mitotic spindle organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000132	establishment of mitotic spindle orientation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9P287	P	Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	C	Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	P	Seeded From UniProt	complete
involved_in	GO:0061101	neuroendocrine cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	P	Seeded From UniProt	complete
involved_in	GO:0034453	microtubule anchoring	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	P	Seeded From UniProt	complete
part_of	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	C	Seeded From UniProt	complete
enables	GO:0019207	kinase regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	F	Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	C	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	P	Seeded From UniProt	complete
involved_in	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9P287 ensembl:ENSP00000357748	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lu, H et al. (2011) Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet. 7 e1002291 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Huhn, SC et al. (2017) Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene 36 4750-4766 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21966279-1] 1.0 ^1.1 Lu, H et al. (2011) Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet. 7 e1002291 PubMed GONUTS page

[PMID:28394342-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Huhn, SC et al. (2017) Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene 36 4750-4766 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:BCCIP

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