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MOUSE:B1AVP8
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Rgs2 | |
| Protein Name(s) | Regulator of G-protein signaling 2 | |
| External Links | ||
| UniProt | B1AVP8 | |
| EMBL | AL713991 CH466520 | |
| IPI | IPI00309304 | |
| RefSeq | NP_033087.2 | |
| UniGene | Mm.28262 | |
| ProteinModelPortal | B1AVP8 | |
| SMR | B1AVP8 | |
| STRING | B1AVP8 | |
| PRIDE | B1AVP8 | |
| GeneID | 19735 | |
| KEGG | mmu:19735 | |
| UCSC | uc007cxg.2 | |
| CTD | 5997 | |
| MGI | MGI:1098271 | |
| GeneTree | ENSGT00610000085916 | |
| HOVERGEN | HBG013233 | |
| InParanoid | B1AVP8 | |
| OMA | AKKIYTD | |
| NextBio | 297172 | |
| Bgee | B1AVP8 | |
| Genevestigator | B1AVP8 | |
| GO | GO:0005737 GO:0005634 GO:0005096 GO:0050873 GO:0007186 GO:0038032 | |
| InterPro | IPR000342 IPR024066 IPR016137 | |
| Gene3D | G3DSA:1.10.196.10 | |
| Pfam | PF00615 | |
| PRINTS | PR01301 | |
| SMART | SM00315 | |
| SUPFAM | SSF48097 | |
| PROSITE | PS50132 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0045744 |
regulation of G-protein coupled receptor protein signaling pathway |
IMP: Inferred from Mutant Phenotype |
P |
Figure 1B:Treatment of RGS2 -/- mice and RGS2 +/+ mice with Gq agonist showed enhanced protein synthesis, especially in RGS2 -/- mice. |
complete | |||
| GO:0010614 |
negative regulation of cardiac muscle hypertrophy |
IMP: Inferred from Mutant Phenotype |
P |
Figure 1C - 1E: After TAC, RGS2 -/- mice developed increased hypertrophy and had a higher mortality rate than RGS2 +/+ mice. |
complete | |||
| GO:0055118 |
negative regulation of cardiac muscle contraction |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2D: TAC treated RGS2 -/- mice hearts failed to compensate by increasing contractibility like RGS2 +/+ hearts. |
complete | |||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
C |
Figure 7B+D:Immunohistochemtistry showed diffuse of RGS2 to the cytosol. |
complete | |||
| GO:0009279 |
cell outer membrane |
IDA: Inferred from Direct Assay |
C |
Figure 7B+D: Immunohistochemistry shows RGS2 localizes to outer membrane. |
complete | |||
| GO:0004871 |
signal transducer activity |
IEA: Inferred from Electronic Annotation |
F |
complete | ||||
| GO:0005096 |
GTPase activator activity |
TAS: Traceable Author Statement |
F |
complete | ||||
| GO:0005634 |
nucleus |
TAS: Traceable Author Statement |
C |
complete | ||||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
complete | ||||
| GO:0007186 |
G-protein coupled receptor protein signaling pathway |
TAS: Traceable Author Statement |
P |
complete | ||||
| GO:0043547 |
positive regulation of GTPase activity |
TAS: Traceable Author Statement |
P |
complete | ||||
| GO:0050873 |
brown fat cell differentiation |
IDA: Inferred from Direct Assay |
P |
complete | ||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Takimoto, E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J. Clin. Invest. 119 408-20 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Nagata, Y et al. (2001) A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood 97 3051-60 PubMed GONUTS page
- ↑ Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page
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