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MOUSE:ATX1L

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Atxn1l (synonyms: Boat)
Protein Name(s) Ataxin-1-like

Brother of ataxin-1

External Links
UniProt P0C7T6
EMBL AC132138
CCDS CCDS40474.1
RefSeq NP_001074399.1
UniGene Mm.276770
ProteinModelPortal P0C7T6
SMR P0C7T6
STRING 10090.ENSMUSP00000090850
PhosphoSite P0C7T6
MaxQB P0C7T6
PRIDE P0C7T6
Ensembl ENSMUST00000093162
GeneID 52335
KEGG mmu:52335
UCSC uc009njh.1
CTD 342371
MGI MGI:3694797
eggNOG NOG306883
GeneTree ENSGT00390000005939
HOGENOM HOG000034225
HOVERGEN HBG100955
InParanoid P0C7T6
OMA TSCSTNH
OrthoDB EOG7PGDQ2
PhylomeDB P0C7T6
TreeFam TF350643
ChiTaRS Atxn1l
NextBio 308800
PRO PR:P0C7T6
Proteomes UP000000589
Bgee P0C7T6
Genevestigator P0C7T6
GO GO:0030425
GO:0005634
GO:0003677
GO:0003723
GO:0030198
GO:0048286
GO:0000122
GO:1902035
GO:0006351
Gene3D 2.170.16.10
InterPro IPR013723
IPR028992
Pfam PF08517
SUPFAM SSF102031
PROSITE PS51148

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007420

brain development

PMID:28288114[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007613

memory

PMID:28288114[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007612

learning

PMID:28288114[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

PMID:28288114[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048856

anatomical structure development

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029907
MGI:MGI:104783
MGI:MGI:3694797
PANTHER:PTN002667577

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104783
MGI:MGI:3694797
PANTHER:PTN000333493

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104783
MGI:MGI:3694797
PANTHER:PTN002667577
UniProtKB:P54253

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104783
PANTHER:PTN002667577
UniProtKB:P0C7T5
UniProtKB:P54253
ZFIN:ZDB-GENE-060503-759
ZFIN:ZDB-GENE-061218-2

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104783
MGI:MGI:3694797
PANTHER:PTN000333493

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902035

positive regulation of hematopoietic stem cell proliferation

PMID:23555280[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5301616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048286

lung alveolus development

PMID:22014525[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104783
MGI:MGI:1918972

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048286

lung alveolus development

PMID:22014525[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5301616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030198

extracellular matrix organization

PMID:22014525[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5301616

P

occurs_in:(EMAPA:32682)

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P0C7T5

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P0C7T5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P0C7T5

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:22014525[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1918972

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:20628574[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1918972

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P0C7T5
ensembl:ENSP00000415822

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P0C7T5
ensembl:ENSP00000415822

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P0C7T5
ensembl:ENSP00000415822

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003652
InterPro:IPR036096

F

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0283

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Lu, HC et al. (2017) Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat. Genet. 49 527-536 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Kahle, JJ et al. (2013) Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery. PLoS Genet. 9 e1003359 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Lee, Y et al. (2011) ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev. Cell 21 746-57 PubMed GONUTS page
  5. ↑ Crespo-Barreto, J et al. (2010) Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis. PLoS Genet. 6 e1001021 PubMed GONUTS page
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