MOUSE:AT2B2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Atp2b2 (synonyms: Pmca2)
Protein Name(s)	Plasma membrane calcium-transporting ATPase 2 PMCA2 Plasma membrane calcium ATPase isoform 2 Plasma membrane calcium pump isoform 2
External Links
UniProt	Q9R0K7
EMBL	AF053471 AB030737 AB030738
CCDS	CCDS20433.1
RefSeq	NP_001031761.1 NP_033853.1
UniGene	Mm.321755 Mm.443564
ProteinModelPortal	Q9R0K7
SMR	Q9R0K7
BioGrid	198250
IntAct	Q9R0K7
MINT	MINT-4088651
STRING	10090.ENSMUSP00000098605
PhosphoSite	Q9R0K7
MaxQB	Q9R0K7
PaxDb	Q9R0K7
PRIDE	Q9R0K7
Ensembl	ENSMUST00000089003 ENSMUST00000101045
GeneID	11941
KEGG	mmu:11941
UCSC	uc009dhn.1
CTD	491
MGI	MGI:105368
eggNOG	COG0474
GeneTree	ENSGT00510000046331
HOGENOM	HOG000265623
HOVERGEN	HBG061286
InParanoid	Q9R0K7
KO	K05850
OrthoDB	EOG7SN8BN
TreeFam	TF300330
Reactome	REACT_247905 REACT_250224
ChiTaRS	Atp2b2
NextBio	280043
PRO	PR:Q9R0K7
Proteomes	UP000000589
Bgee	Q9R0K7
CleanEx	MM_ATP2B2
ExpressionAtlas	Q9R0K7
Genevestigator	Q9R0K7
GO	GO:0016324 GO:0030054 GO:0005929 GO:0005737 GO:0005783 GO:0016021 GO:0043025 GO:0005886 GO:0045202 GO:0005524 GO:0005509 GO:0030899 GO:0005388 GO:0005516 GO:0030165 GO:0008022 GO:0006200 GO:0060088 GO:0006816 GO:0000902 GO:0006874 GO:0021707 GO:0021702 GO:0021692 GO:0021549 GO:0046068 GO:0090102 GO:0051480 GO:0050910 GO:0048839 GO:0042472 GO:0060113 GO:0007595 GO:0040011 GO:0007626 GO:0050885 GO:0030182 GO:0006996 GO:0045299 GO:0051928 GO:0008361 GO:0048167 GO:0007605 GO:0042428 GO:0050808
Gene3D	1.20.1110.10
InterPro	IPR030322 IPR022141 IPR006068 IPR004014 IPR023299 IPR018303 IPR023298 IPR008250 IPR023214 IPR006408 IPR001757
PANTHER	PTHR24093:SF247
Pfam	PF12424 PF00689 PF00690 PF00122 PF00702
PRINTS	PR00119
SMART	SM00831
SUPFAM	SSF56784 SSF81660
TIGRFAMs	TIGR01517 TIGR01494
PROSITE	PS00154

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090102	cochlea development	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:17234811^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:17234811^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814-1	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814-1	F		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814-6	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814-1	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814-1	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814-1	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01814-6	F		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643875 RGD:2176	C		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105368 PANTHER:PTN001184751 UniProtKB:P20020 UniProtKB:Q01814 UniProtKB:Q16720	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643848 RGD:2176 RGD:621303 RGD:621304 RGD:621305 UniProtKB:Q01814	F		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259214 MGI:MGI:105368 MGI:MGI:88111 PANTHER:PTN000643846 PomBase:SPAPB2B4.04c SGD:S000002974 UniProtKB:P23634 UniProtKB:Q4WT17 UniProtKB:Q5B3G0 UniProtKB:Q5BE41 WB:WBGene00003151	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000642960 UniProtKB:P9WPS9	C		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000643812 RGD:2176 RGD:621305 SGD:S000002974 TAIR:locus:2094726 TAIR:locus:2175579 UniProtKB:P23634 UniProtKB:Q01814 WB:WBGene00003151 dictyBase:DDB_G0277861	F		Seeded From UniProt	complete
enables	GO:1905059	calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
enables	GO:1905056	calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060113	inner ear receptor cell differentiation	PMID:11875276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799	P	occurs_in:(EMAPA:19151)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060088	auditory receptor cell stereocilium organization	PMID:11875276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000202)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051928	positive regulation of calcium ion transport	PMID:17823248^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	PMID:16529873^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	occurs_in:(EMAPA:17597) occurs_in:(CL:0000202)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:16845470^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3641249	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:15350283^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:7683393^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:11875276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799	P	results_in_development_of:(EMAPA:19151)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:17409239^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	regulates_o_has_participant:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046068	cGMP metabolic process	PMID:7518067^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P	occurs_in:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046068	cGMP metabolic process	PMID:3038581^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P	occurs_in:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045299	otolith mineralization	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	has_participant:(EMAPA:17293)\|has_participant:(EMAPA:17290)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:10441500^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17597) part_of:(CL:0000589)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	has_participant:(EMAPA:19151)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042428	serotonin metabolic process	PMID:2765934^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P	occurs_in:(EMAPA:16470)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040011	locomotion	PMID:16880690^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3664103	P		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	F		Seeded From UniProt	complete
part_of	GO:0032809	neuronal cell body membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
enables	GO:0030899	calcium-dependent ATPase activity	PMID:17823248^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(EMAPA:17759) occurs_in:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021707	cerebellar granule cell differentiation	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	occurs_in:(EMAPA:17787) results_in_acquisition_of_features_of:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021702	cerebellar Purkinje cell differentiation	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	occurs_in:(EMAPA:17787) results_in_acquisition_of_features_of:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021692	cerebellar Purkinje cell layer morphogenesis	PMID:17409239^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021549	cerebellum development	PMID:16880690^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3664103	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:17823248^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17759) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008361	regulation of cell size	PMID:11875276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799	P	regulates_o_occurs_in:(EMAPA:19151)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:7518067^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:3038581^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:2765934^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:16845470^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3641249	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:9325047^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890219	P	has_participant:(EMAPA:32678)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:9697703^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799 MGI:MGI:1857396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:9668038^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:9325047^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857396	P	has_participant:(EMAPA:32678)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:17234811^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799 MGI:MGI:1857876	P	has_participant:(EMAPA:17597)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:16845470^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3641249	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:15350283^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934613	P	has_participant:(EMAPA:32678)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:11950541^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:10687933^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007595	lactation	PMID:15302868^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	has_participant:(EMAPA:36540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006996	organelle organization	PMID:11875276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799	P	occurs_in:(EMAPA:19151)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:17234811^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799 MGI:MGI:1857876	P	occurs_in:(EMAPA:17293) occurs_in:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:11985881^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P	occurs_in:(EMAPA:35223) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:17234811^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856799 MGI:MGI:1857876	P	occurs_in:(EMAPA:17293) occurs_in:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:15302868^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857876	P	occurs_in:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:10441500^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17597) part_of:(CL:0000601)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17234811^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17234811^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q01814	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2176	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:10441500^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857092	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099132	ATP hydrolysis coupled cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005388	P		Seeded From UniProt	complete
involved_in	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1905056	P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1905059	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023299	F		Seeded From UniProt	complete
enables	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408 InterPro:IPR022141	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001757	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006408	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Kozel, PJ et al. (1998) Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J. Biol. Chem. 273 18693-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Ficarella, R et al. (2007) A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness. Proc. Natl. Acad. Sci. U.S.A. 104 1516-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Dodson, HC & Charalabapoulou, M (2001) PMCA2 mutation causes structural changes in the auditory system in deafwaddler mice. J. Neurocytol. 30 281-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 VanHouten, JN et al. (2007) The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology 148 5943-54 PubMed GONUTS page
↑ Hunt, DL et al. (2006) Multisensory plasticity in congenitally deaf mice: how are cortical areas functionally specified? Neuroscience 139 1507-24 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Tsai, YS et al. (2006) A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. Mamm. Genome 17 716-22 PubMed GONUTS page
↑ ^8.0 ^8.1 McCullough, BJ & Tempel, BL (2004) Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia. Hear. Res. 195 90-102 PubMed GONUTS page
↑ Inoue, Y et al. (1993) Abnormal synaptic architecture in the cerebellar cortex of a new dystonic mutant mouse, Wriggle Mouse Sagami. Neurosci. Res. 16 39-48 PubMed GONUTS page
↑ ^10.0 ^10.1 Empson, RM et al. (2007) Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J. Neurosci. 27 3753-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Ikeda, M et al. (1994) Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami. Neurosci. Lett. 168 65-8 PubMed GONUTS page
↑ ^12.0 ^12.1 Matsui, K et al. (1987) [Fundamental study on ataxic mice (wriggle mouse Sagami)]. Jikken Dobutsu 36 185-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Takahashi, K & Kitamura, K (1999) A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami. Biochem. Biophys. Res. Commun. 261 773-8 PubMed GONUTS page
↑ ^14.0 ^14.1 Ikeda, M et al. (1989) A neurochemical study of a new mutant mouse presenting myoclonus-like involuntary movement: a possible model of spontaneous serotonergic hyperactivity. Brain Res. 495 337-48 PubMed GONUTS page
↑ ^15.0 ^15.1 Chen, Z et al. (2006) A novel mutant mouse, joggle, with inherited ataxia. Exp. Anim. 55 411-4 PubMed GONUTS page
↑ ^16.0 ^16.1 Noben-Trauth, K et al. (1997) mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44 266-72 PubMed GONUTS page
↑ Street, VA et al. (1998) Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice. Nat. Genet. 19 390-4 PubMed GONUTS page
↑ Kozel, PJ et al. (2002) Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hear. Res. 164 231-9 PubMed GONUTS page
↑ Takahashi, K et al. (1999) Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami. Acta Otolaryngol. 119 767-72 PubMed GONUTS page
↑ ^20.0 ^20.1 Reinhardt, TA et al. (2004) Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J. Biol. Chem. 279 42369-73 PubMed GONUTS page
↑ Ueno, T et al. (2002) A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons. Neurosci. Res. 42 287-97 PubMed GONUTS page

[PMID:9668038-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Kozel, PJ et al. (1998) Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J. Biol. Chem. 273 18693-6 PubMed GONUTS page

[PMID:17234811-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Ficarella, R et al. (2007) A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness. Proc. Natl. Acad. Sci. U.S.A. 104 1516-21 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11875276-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Dodson, HC & Charalabapoulou, M (2001) PMCA2 mutation causes structural changes in the auditory system in deafwaddler mice. J. Neurocytol. 30 281-92 PubMed GONUTS page

[PMID:17823248-5] 5.0 ^5.1 ^5.2 VanHouten, JN et al. (2007) The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology 148 5943-54 PubMed GONUTS page

[PMID:16529873-6] Hunt, DL et al. (2006) Multisensory plasticity in congenitally deaf mice: how are cortical areas functionally specified? Neuroscience 139 1507-24 PubMed GONUTS page

[PMID:16845470-7] 7.0 ^7.1 ^7.2 Tsai, YS et al. (2006) A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. Mamm. Genome 17 716-22 PubMed GONUTS page

[PMID:15350283-8] 8.0 ^8.1 McCullough, BJ & Tempel, BL (2004) Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia. Hear. Res. 195 90-102 PubMed GONUTS page

[PMID:7683393-9] Inoue, Y et al. (1993) Abnormal synaptic architecture in the cerebellar cortex of a new dystonic mutant mouse, Wriggle Mouse Sagami. Neurosci. Res. 16 39-48 PubMed GONUTS page

[PMID:17409239-10] 10.0 ^10.1 Empson, RM et al. (2007) Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J. Neurosci. 27 3753-8 PubMed GONUTS page

[PMID:7518067-11] 11.0 ^11.1 Ikeda, M et al. (1994) Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami. Neurosci. Lett. 168 65-8 PubMed GONUTS page

[PMID:3038581-12] 12.0 ^12.1 Matsui, K et al. (1987) [Fundamental study on ataxic mice (wriggle mouse Sagami)]. Jikken Dobutsu 36 185-9 PubMed GONUTS page

[PMID:10441500-13] 13.0 ^13.1 ^13.2 Takahashi, K & Kitamura, K (1999) A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami. Biochem. Biophys. Res. Commun. 261 773-8 PubMed GONUTS page

[PMID:2765934-14] 14.0 ^14.1 Ikeda, M et al. (1989) A neurochemical study of a new mutant mouse presenting myoclonus-like involuntary movement: a possible model of spontaneous serotonergic hyperactivity. Brain Res. 495 337-48 PubMed GONUTS page

[PMID:16880690-15] 15.0 ^15.1 Chen, Z et al. (2006) A novel mutant mouse, joggle, with inherited ataxia. Exp. Anim. 55 411-4 PubMed GONUTS page

[PMID:9325047-16] 16.0 ^16.1 Noben-Trauth, K et al. (1997) mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44 266-72 PubMed GONUTS page

[PMID:9697703-17] Street, VA et al. (1998) Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice. Nat. Genet. 19 390-4 PubMed GONUTS page

[PMID:11950541-18] Kozel, PJ et al. (2002) Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hear. Res. 164 231-9 PubMed GONUTS page

[PMID:10687933-19] Takahashi, K et al. (1999) Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami. Acta Otolaryngol. 119 767-72 PubMed GONUTS page

[PMID:15302868-20] 20.0 ^20.1 Reinhardt, TA et al. (2004) Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J. Biol. Chem. 279 42369-73 PubMed GONUTS page

[PMID:11985881-21] Ueno, T et al. (2002) A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons. Neurosci. Res. 42 287-97 PubMed GONUTS page

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