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PMID:17409239
| Citation |
Empson, RM, Garside, ML and Knöpfel, T (2007) Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J. Neurosci. 27:3753-8 |
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| Abstract |
Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2-/- knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function. |
| Links |
PubMed Online version:10.1523/JNEUROSCI.0069-07.2007 |
| Keywords |
Animals; Cerebellum/enzymology; Female; Isoenzymes/deficiency; Isoenzymes/genetics; Isoenzymes/physiology; Male; Mice; Mice, Knockout; Muscle Fibers, Fast-Twitch/enzymology; Neuronal Plasticity/physiology; Plasma Membrane Calcium-Transporting ATPases/deficiency; Plasma Membrane Calcium-Transporting ATPases/genetics; Plasma Membrane Calcium-Transporting ATPases/physiology; Purkinje Cells/enzymology; Reaction Time; Synapses/enzymology; Synapses/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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