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MOUSE:ASXL2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Asxl2 (synonyms: Kiaa1685)
Protein Name(s) Putative Polycomb group protein ASXL2

Additional sex combs-like protein 2

External Links
UniProt Q8BZ32
EMBL AK036839
AK162455
AK122540
CCDS CCDS36395.2
RefSeq NP_001257917.1
NP_766009.2
UniGene Mm.120475
ProteinModelPortal Q8BZ32
BioGrid 217375
STRING 10090.ENSMUSP00000106846
iPTMnet Q8BZ32
PhosphoSite Q8BZ32
MaxQB Q8BZ32
PaxDb Q8BZ32
PRIDE Q8BZ32
GeneID 75302
KEGG mmu:75302
CTD 55252
MGI MGI:1922552
eggNOG ENOG410IIF3
ENOG4111F3G
HOGENOM HOG000168836
HOVERGEN HBG106941
InParanoid Q8BZ32
KO K11471
ChiTaRS Asxl2
NextBio 13876799
PRO PR:Q8BZ32
Proteomes UP000000589
CleanEx MM_ASXL2
GO GO:0005654
GO:0005634
GO:0003677
GO:0046872
GO:0042975
GO:0007512
GO:0048704
GO:0007507
GO:0003007
GO:0000122
GO:1900159
GO:0045600
GO:1902466
GO:0045672
GO:0035360
GO:0045944
GO:0006351
InterPro IPR026905
IPR024811
IPR028020
IPR024817
IPR007759
PANTHER PTHR13578
PTHR13578:SF11
Pfam PF13919
PF05066
PF13922

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76L83

P

Seeded From UniProt

complete

involved_in

GO:0045600

positive regulation of fat cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76L83

P

Seeded From UniProt

complete

enables

GO:0042975

peroxisome proliferator activated receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76L83

F

Seeded From UniProt

complete

involved_in

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76L83

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684063
PANTHER:PTN000339786
UniProtKB:Q76L83

P

Seeded From UniProt

complete

enables

GO:0042975

peroxisome proliferator activated receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684063
PANTHER:PTN000339788
UniProtKB:Q76L83

F

Seeded From UniProt

complete

part_of

GO:0035517

PR-DUB complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261823
PANTHER:PTN000339786
UniProtKB:Q8IXJ9

C

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684063
PANTHER:PTN000339786

P

Seeded From UniProt

complete

colocalizes_with

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261823
MGI:MGI:1922552
MGI:MGI:2684063
PANTHER:PTN000339786

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261823
PANTHER:PTN000339786

F

Seeded From UniProt

complete

colocalizes_with

GO:0000790

nuclear chromatin

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1922552
PANTHER:PTN000339786

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902466

positive regulation of histone H3-K27 trimethylation

PMID:19270745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3840841

P

regulates_o_occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900159

positive regulation of bone mineralization involved in bone maturation

PMID:21490954[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3840841

P

regulates_o_occurs_in:(EMAPA:32782)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048704

embryonic skeletal system morphogenesis

PMID:19270745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3840841

P

has_participant:(EMAPA:17214)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q76L83

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045672

positive regulation of osteoclast differentiation

PMID:21490954[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_results_in_acquisition_of_features_of:(CL:0002476)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045600

positive regulation of fat cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q76L83

P

Seeded From UniProt

complete

enables

GO:0042975

peroxisome proliferator activated receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q76L83

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q76L83

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007512

adult heart development

PMID:23046516[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3840841

P

results_in_development_of:(EMAPA:17331)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:19270745[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3840841

P

results_in_development_of:(EMAPA:16105)

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q76L83

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20577743[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003007

heart morphogenesis

PMID:24860998[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3840841

P

Seeded From UniProt

complete

colocalizes_with

GO:0000790

nuclear chromatin

PMID:23046516[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:23046516[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3840841

P

has_regulation_target:(MGI:MGI:2155600)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026905

F

Seeded From UniProt

complete

involved_in

GO:0006351

transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007759

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007759

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 Baskind, HA et al. (2009) Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. PLoS ONE 4 e4750 PubMed GONUTS page
  3. 3.0 3.1 Farber, CR et al. (2011) Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet. 7 e1002038 PubMed GONUTS page
  4. 4.0 4.1 4.2 Lai, HL et al. (2012) Maintenance of adult cardiac function requires the chromatin factor Asxl2. J. Mol. Cell. Cardiol. 53 734-41 PubMed GONUTS page
  5. Saferali, A et al. (2010) Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mamm. Genome 21 377-87 PubMed GONUTS page
  6. McGinley, AL et al. (2014) Additional sex combs-like family genes are required for normal cardiovascular development. Genesis 52 671-86 PubMed GONUTS page