MOUSE:ANGT

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Agt (synonyms: Serpina8)
Protein Name(s)	Angiotensinogen Serpin A8 Angiotensin-1 Angiotensin 1-10 Angiotensin I Ang I Angiotensin-2 Angiotensin 1-8 Angiotensin II Ang II Angiotensin-3 Angiotensin 2-8 Angiotensin III Ang III Des-Asp[1]-angiotensin II Angiotensin-4 Angiotensin 3-8 Angiotensin IV Ang IV Angiotensin 1-9 Angiotensin 1-7 Angiotensin 1-5 Angiotensin 1-4
External Links
UniProt	P11859
EMBL	AF045887 AF045886 AF045885 AF045884
PIR	A29978
UniGene	Mm.301626
PDB	2WXX 2WXY 2WY0
PDBsum	2WXX 2WXY 2WY0
ProteinModelPortal	P11859
SMR	P11859
STRING	10090.ENSMUSP00000066488
MEROPS	I04.953
PhosphoSite	P11859
EPD	P11859
MaxQB	P11859
PaxDb	P11859
PRIDE	P11859
MGI	MGI:87963
eggNOG	KOG2392 COG4826
HOVERGEN	HBG004233
InParanoid	P11859
PhylomeDB	P11859
EvolutionaryTrace	P11859
PRO	PR:P11859
Proteomes	UP000000589
GO	GO:0072562 GO:0070062 GO:0005615 GO:0005622 GO:0004867 GO:0017080 GO:0031702 GO:0031703 GO:0007250 GO:0001998 GO:0048143 GO:0001568 GO:0002035 GO:0001658 GO:0007160 GO:0042756 GO:0008065 GO:0007588 GO:0030198 GO:0007186 GO:0042445 GO:0001822 GO:0008285 GO:0010951 GO:0043524 GO:0051387 GO:0001543 GO:0030432 GO:0010535 GO:0090190 GO:0032270 GO:0010873 GO:0050715 GO:0010595 GO:0045742 GO:2001238 GO:0045723 GO:1903598 GO:0010628 GO:0043410 GO:1902632 GO:0040018 GO:0046622 GO:0033138 GO:0050731 GO:0014068 GO:1900020 GO:0061098 GO:0045893 GO:0042981 GO:0008217 GO:1903779 GO:1901201 GO:0010468 GO:0050727 GO:0002019 GO:0001991 GO:0001999 GO:0003014 GO:0002018 GO:0009409 GO:0009651 GO:0051145 GO:0048659
InterPro	IPR000227 IPR023796 IPR000215
PANTHER	PTHR11461
Pfam	PF00079
PRINTS	PR00654
SMART	SM00093
SUPFAM	SSF56574

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0050715	positive regulation of cytokine secretion	PMID:19023134^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028988 FB:FBgn0265137 PANTHER:PTN000156123 RGD:3249 UniProtKB:P05121 UniProtKB:P29508 UniProtKB:P35237 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q9UIV8	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0015586 FB:FBgn0028986 FB:FBgn0031973 FB:FBgn0262057 FB:FBgn0265137 MGI:MGI:108080 MGI:MGI:1915304 MGI:MGI:87963 MGI:MGI:88278 MGI:MGI:894696 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:2069 RGD:3249 RGD:3326 RGD:3747 RGD:3748 RGD:619833 RGD:631369 RGD:735225 UniProtKB:P01008 UniProtKB:P01009 UniProtKB:P01011 UniProtKB:P01019 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P08697 UniProtKB:P50453 UniProtKB:Q90935 UniProtKB:Q99574 UniProtKB:Q9TTE1	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0028983 FB:FBgn0028988 FB:FBgn0028990 FB:FBgn0265137 MGI:MGI:101780 MGI:MGI:106603 MGI:MGI:1277952 MGI:MGI:2445361 MGI:MGI:2683293 MGI:MGI:891970 MGI:MGI:894696 MGI:MGI:97608 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:3249 RGD:3326 RGD:3748 RGD:619817 RGD:619896 RGD:619897 UniProtKB:P01009 UniProtKB:P01012 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P05155 UniProtKB:P07093 UniProtKB:P08697 UniProtKB:P35237 UniProtKB:P48594 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q3ZEJ6 UniProtKB:Q86WD7 UniProtKB:Q90935 UniProtKB:Q96P63 UniProtKB:Q99574 UniProtKB:Q9TTE1 UniProtKB:Q9UIV8 WB:WBGene00005643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905589	positive regulation of L-arginine import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905010	positive regulation of L-lysine import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903779	regulation of cardiac conduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903598	positive regulation of gap junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901201	regulation of extracellular matrix assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900020	positive regulation of protein kinase C activity	PMID:23775122^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97595)\|has_regulation_target:(MGI:MGI:97596)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070471	uterine smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061049	cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051969	regulation of transmission of nerve impulse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051924	regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051403	stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051145	smooth muscle cell differentiation	PMID:9788961^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P	occurs_in:(EMAPA:17948) results_in_acquisition_of_features_of:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051145	smooth muscle cell differentiation	PMID:9788961^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17950) results_in_acquisition_of_features_of:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:19404405^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98259	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:19404405^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050663	cytokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048659	smooth muscle cell proliferation	PMID:9788961^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P	occurs_in:(EMAPA:17948) acts_on_population_of:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048659	smooth muscle cell proliferation	PMID:9788961^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17950) acts_on_population_of:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048659	smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048144	fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048143	astrocyte activation	PMID:9734405^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046622	positive regulation of organ growth	PMID:12660889^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046622	positive regulation of organ growth	PMID:16374517^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045777	positive regulation of blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:11606482^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:9310306^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P	occurs_in:(EMAPA:19148) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:9196031^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P	regulates_o_occurs_in:(EMAPA:16105) regulates_o_occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043085	positive regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:19404405^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042756	drinking behavior	PMID:9852267^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042445	hormone metabolic process	PMID:12660889^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P	has_input:(MGI:MGI:96573)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042311	vasodilation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042310	vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040018	positive regulation of multicellular organism growth	PMID:12660889^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035815	positive regulation of renal sodium excretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035813	regulation of renal sodium excretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035106	operant conditioning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034104	negative regulation of tissue remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:23775122^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(MGI:MGI:109334)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
enables	GO:0031703	type 2 angiotensin receptor binding	PMID:9878677^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35374	F	occurs_in:(EMAPA:32780)	Seeded From UniProt	complete
enables	GO:0031703	type 2 angiotensin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	F		Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	PMID:9878677^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:18207)\|occurs_in:(EMAPA:32789)\|occurs_in:(EMAPA:32780)	Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030432	peristalsis	PMID:9788961^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P	occurs_in:(EMAPA:17948)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:9734405^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014873	response to muscle activity involved in regulation of muscle adaptation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014824	artery smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014061	regulation of norepinephrine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010873	positive regulation of cholesterol esterification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:19404405^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96559)\|has_regulation_target:(MGI:MGI:98259)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010536	positive regulation of activation of Janus kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:16585392^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:891981)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009651	response to salt stress	PMID:9557921^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009409	response to cold	PMID:12574102^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:8675666^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11606482^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:30449)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10318840^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008217	regulation of blood pressure	PMID:9557921^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008217	regulation of blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008065	establishment of blood-nerve barrier	PMID:9734405^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P	has_participant:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007588	excretion	PMID:9557921^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007250	activation of NF-kappaB-inducing kinase activity	PMID:19404405^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007202	activation of phospholipase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	PMID:9734405^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006883	cellular sodium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:7989296^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35690)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11606482^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35690) part_of:(CL:0000448)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10425188^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003331	positive regulation of extracellular matrix constituent secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003051	angiotensin-mediated drinking behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003014	renal system process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002035	brain renin-angiotensin system	PMID:9878677^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:18207)\|has_participant:(EMAPA:32789)\|has_participant:(EMAPA:32780)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002035	brain renin-angiotensin system	PMID:15499027^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002027	regulation of heart rate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002019	regulation of renal output by angiotensin	PMID:9852267^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P	regulates_o_has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002019	regulation of renal output by angiotensin	PMID:9507198^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P	regulates_o_has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002019	regulation of renal output by angiotensin	PMID:11606482^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002018	renin-angiotensin regulation of aldosterone production	PMID:9852267^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002018	renin-angiotensin regulation of aldosterone production	PMID:10076178^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002018	renin-angiotensin regulation of aldosterone production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001999	renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure	PMID:11606482^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001998	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	PMID:10425188^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:18601)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	PMID:9852267^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	PMID:9507198^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	PMID:9466969^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	PMID:7989296^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	PMID:12574102^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857121	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	PMID:11606482^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	PMID:10076178^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136636	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:9466969^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P	results_in_development_of:(EMAPA:18676)\|results_in_development_of:(EMAPA:35655)\|results_in_development_of:(EMAPA:28239)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:8675666^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P	results_in_development_of:(EMAPA:17948)\|results_in_development_of:(EMAPA:19279)\|results_in_development_of:(EMAPA:35655)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:12657564^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:9466969^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P	occurs_in:(EMAPA:28373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:8675666^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183545	P	occurs_in:(EMAPA:17373)\|occurs_in:(EMAPA:35147)\|occurs_in:(EMAPA:17373)\|occurs_in:(EMAPA:35146)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001543	ovarian follicle rupture	PMID:11384650^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857122	P	has_participant:(EMAPA:35627)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000227	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000215	C		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0839	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0838	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Jaffré, F et al. (2009) Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ. Res. 104 113-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Park, K et al. (2013) Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol. Cell. Biol. 33 3227-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Miyazaki, Y et al. (1998) Angiotensin induces the urinary peristaltic machinery during the perinatal period. J. Clin. Invest. 102 1489-97 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Kakinuma, Y et al. (1998) Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat. Med. 4 1078-80 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Kim, S et al. () Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression. Horm. Metab. Res. 34 721-5 PubMed GONUTS page
↑ Peng, X et al. (2006) Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J. Clin. Invest. 116 217-27 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Massiéra, F et al. (2001) Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 15 2727-9 PubMed GONUTS page
↑ Kakinuma, Y et al. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci. Lett. 232 167-70 PubMed GONUTS page
↑ Nyui, N et al. (1997) Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. Biochem. Biophys. Res. Commun. 235 36-41 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Taniguchi, K et al. (1998) Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice. Int. J. Mol. Med. 1 583-7 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Daubert, DL et al. (1999) Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res. 816 8-16 PubMed GONUTS page
↑ Itoh, S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113 1787-98 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Umemura, S et al. (1998) Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading. J. Hypertens. 16 285-9 PubMed GONUTS page
↑ ^16.0 ^16.1 Sun, Z et al. (2003) Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension 41 322-7 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Niimura, F et al. (1995) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J. Clin. Invest. 96 2947-54 PubMed GONUTS page
↑ Kim, HS et al. (1999) Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J. Biol. Chem. 274 14210-7 PubMed GONUTS page
↑ ^19.0 ^19.1 Tanimoto, K et al. (1994) Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269 31334-7 PubMed GONUTS page
↑ ^20.0 ^20.1 Akishita, M et al. (1999) Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem. Biophys. Res. Commun. 261 345-9 PubMed GONUTS page
↑ Kazama, K et al. (2004) Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ. Res. 95 1019-26 PubMed GONUTS page
↑ ^22.0 ^22.1 Kihara, M et al. (1998) Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int. 53 548-55 PubMed GONUTS page
↑ ^23.0 ^23.1 Tamura, K et al. (1999) Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. J. Endocrinol. 160 401-8 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Tsuchida, S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J. Clin. Invest. 101 755-60 PubMed GONUTS page
↑ Iosipiv, IV & Schroeder, M (2003) A role for angiotensin II AT1 receptors in ureteric bud cell branching. Am. J. Physiol. Renal Physiol. 285 F199-207 PubMed GONUTS page
↑ Hefler, LA & Gregg, AR (2001) Influence of the angiotensinogen gene on the ovulatory capacity of mice. Fertil. Steril. 75 1206-11 PubMed GONUTS page

[PMID:19023134-1] Jaffré, F et al. (2009) Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ. Res. 104 113-23 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23775122-3] 3.0 ^3.1 Park, K et al. (2013) Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol. Cell. Biol. 33 3227-41 PubMed GONUTS page

[PMID:9788961-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Miyazaki, Y et al. (1998) Angiotensin induces the urinary peristaltic machinery during the perinatal period. J. Clin. Invest. 102 1489-97 PubMed GONUTS page

[PMID:19404405-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page

[PMID:9734405-6] 6.0 ^6.1 ^6.2 ^6.3 Kakinuma, Y et al. (1998) Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat. Med. 4 1078-80 PubMed GONUTS page

[PMID:12660889-7] 7.0 ^7.1 ^7.2 Kim, S et al. () Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression. Horm. Metab. Res. 34 721-5 PubMed GONUTS page

[PMID:16374517-8] Peng, X et al. (2006) Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J. Clin. Invest. 116 217-27 PubMed GONUTS page

[PMID:11606482-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Massiéra, F et al. (2001) Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 15 2727-9 PubMed GONUTS page

[PMID:9310306-10] Kakinuma, Y et al. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci. Lett. 232 167-70 PubMed GONUTS page

[PMID:9196031-11] Nyui, N et al. (1997) Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. Biochem. Biophys. Res. Commun. 235 36-41 PubMed GONUTS page

[PMID:9852267-12] 12.0 ^12.1 ^12.2 ^12.3 Taniguchi, K et al. (1998) Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice. Int. J. Mol. Med. 1 583-7 PubMed GONUTS page

[PMID:9878677-13] 13.0 ^13.1 ^13.2 Daubert, DL et al. (1999) Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res. 816 8-16 PubMed GONUTS page

[PMID:16585392-14] Itoh, S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113 1787-98 PubMed GONUTS page

[PMID:9557921-15] 15.0 ^15.1 ^15.2 Umemura, S et al. (1998) Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading. J. Hypertens. 16 285-9 PubMed GONUTS page

[PMID:12574102-16] 16.0 ^16.1 Sun, Z et al. (2003) Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension 41 322-7 PubMed GONUTS page

[PMID:8675666-17] 17.0 ^17.1 ^17.2 Niimura, F et al. (1995) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J. Clin. Invest. 96 2947-54 PubMed GONUTS page

[PMID:10318840-18] Kim, HS et al. (1999) Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J. Biol. Chem. 274 14210-7 PubMed GONUTS page

[PMID:7989296-19] 19.0 ^19.1 Tanimoto, K et al. (1994) Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269 31334-7 PubMed GONUTS page

[PMID:10425188-20] 20.0 ^20.1 Akishita, M et al. (1999) Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem. Biophys. Res. Commun. 261 345-9 PubMed GONUTS page

[PMID:15499027-21] Kazama, K et al. (2004) Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ. Res. 95 1019-26 PubMed GONUTS page

[PMID:9507198-22] 22.0 ^22.1 Kihara, M et al. (1998) Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int. 53 548-55 PubMed GONUTS page

[PMID:10076178-23] 23.0 ^23.1 Tamura, K et al. (1999) Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. J. Endocrinol. 160 401-8 PubMed GONUTS page

[PMID:9466969-24] 24.0 ^24.1 ^24.2 Tsuchida, S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J. Clin. Invest. 101 755-60 PubMed GONUTS page

[PMID:12657564-25] Iosipiv, IV & Schroeder, M (2003) A role for angiotensin II AT1 receptors in ureteric bud cell branching. Am. J. Physiol. Renal Physiol. 285 F199-207 PubMed GONUTS page

[PMID:11384650-26] Hefler, LA & Gregg, AR (2001) Influence of the angiotensinogen gene on the ovulatory capacity of mice. Fertil. Steril. 75 1206-11 PubMed GONUTS page

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