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MOUSE:AKAP5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Akap5 (synonyms: Akap150) | |
| Protein Name(s) | A-kinase anchor protein 5
AKAP-5 A-kinase anchor protein 150 kDa AKAP 150 P150 cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein | |
| External Links | ||
| UniProt | D3YVF0 | |
| EMBL | AC120002 | |
| CCDS | CCDS49092.1 | |
| RefSeq | NP_001094941.1 | |
| UniGene | Mm.311452 | |
| ProteinModelPortal | D3YVF0 | |
| SMR | D3YVF0 | |
| BioGrid | 231964 | |
| IntAct | D3YVF0 | |
| MINT | MINT-8412175 | |
| STRING | 10090.ENSMUSP00000114495 | |
| iPTMnet | D3YVF0 | |
| PhosphoSitePlus | D3YVF0 | |
| MaxQB | D3YVF0 | |
| PaxDb | D3YVF0 | |
| PeptideAtlas | D3YVF0 | |
| PRIDE | D3YVF0 | |
| Ensembl | ENSMUST00000154078 | |
| GeneID | 238276 | |
| KEGG | mmu:238276 | |
| UCSC | uc007nya.2 | |
| CTD | 9495 | |
| MGI | MGI:2685104 | |
| eggNOG | ENOG410IIWH ENOG4111833 | |
| GeneTree | ENSGT00390000019941 | |
| HOGENOM | HOG000168350 | |
| InParanoid | D3YVF0 | |
| KO | K16522 | |
| PhylomeDB | D3YVF0 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-399719 R-MMU-399719] | |
| PRO | PR:D3YVF0 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000021057 | |
| ExpressionAtlas | D3YVF0 | |
| Genevisible | D3YVF0 | |
| GO | GO:0005856 GO:0005886 GO:0008179 GO:0034237 GO:0036394 GO:0030819 GO:0010739 GO:0006605 GO:0007165 | |
| InterPro | IPR001573 | |
| Pfam | PF03832 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045161 |
neuronal ion channel clustering |
ECO:0000314 |
P |
AKAP150 facilitates the formation of neuronal ion channel clusters as indicated in figures 3A-D. UniProt Nomenclature: A-kinase anchor protein 5 (AKAP5_MOUSE) Uniprot ID: D3YVF0 Organism: Mus musculus |
complete | |||||
| GO:0043113 |
receptor clustering |
ECO:0000314 |
P |
Figures 3E and 3F confirm that AKAP150 clusters with muscarinic 1 acetylcholine receptors (M1R). UniProt Nomenclature for AKAP150: A-kinase anchor protein 5 (AKAP5_MOUSE) Uniprot ID: D3YVF0 UniProt Nomenclature for M1R: Muscarinic acetylcholine receptor M1 (ACM1_MOUSE) Uniprot ID: P12657 Organism: Mus musculus |
complete | |||||
| GO:0070073 |
clustering of voltage-gated calcium channels |
ECO:0000315 |
P |
AKAP150 forms “super-clusters” of voltage-gated calcium channels (Cav1.2) as seen in Figure 7A. It’s worth noting that absence of these clusters in the AKAP150 KO mouse in Figure 7B reveals the necessity of AKAP150 to form these clusters. Uniprot Nomenclature: A-kinase anchor protein 5 (AKAP5_MOUSE) Uniprot ID: D3YVF0 Organism: Mus musculus |
complete | |||||
| GO:0045163 |
clustering of voltage-gated potassium channels |
ECO:0000314 |
P |
AKAP150 facilitates clustering of voltage-gated potassium channels which include KCNQ2, as seen in Figure 3A and Figure 6A in peripheral nervous system neurons. Uniprot Nomenclature: A-kinase anchor protein 5 (AKAP5_MOUSE) Uniprot ID: D3YVF0 Organism: Mus musculus |
complete | |||||
| GO:0030159 |
receptor signaling complex scaffold activity |
ECO:0000314 |
F |
AKAP150 scaffolding facilitates the functional coupling (Figure 4) of muscarinic 1 receptor signaling to suppression of KCNQ2 channels at the membrane of superior cervical ganglion neurons. Uniprot Nomenclature: A-kinase anchor protein 5 (AKAP5_MOUSE) Uniprot ID: D3YVF0 Organism: Mus musculus |
complete | |||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007194 |
negative regulation of adenylate cyclase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0060090 |
molecular adaptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0060076 |
excitatory synapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0050811 |
GABA receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045762 |
positive regulation of adenylate cyclase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043197 |
dendritic spine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035254 |
glutamate receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034237 |
protein kinase A regulatory subunit binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032590 |
dendrite membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031698 |
beta-2 adrenergic receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000389662 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008179 |
adenylate cyclase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2685104 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2685104 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0099149 |
regulation of postsynaptic neurotransmitter receptor internalization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099092 |
postsynaptic density, intracellular component |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0097110 |
scaffold protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0097110 |
scaffold protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070886 |
positive regulation of calcineurin-NFAT signaling cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0060090 |
molecular adaptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0060076 |
excitatory synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0050811 |
GABA receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050775 |
positive regulation of dendrite morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045762 |
positive regulation of adenylate cyclase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045296 |
cadherin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043624 |
cellular protein complex disassembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043271 |
negative regulation of ion transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043267 |
negative regulation of potassium ion transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043198 |
dendritic shaft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043197 |
dendritic spine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042307 |
positive regulation of protein import into nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0036394 |
amylase secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3766311 |
P |
|
Seeded From UniProt |
complete | |
|
enables |
GO:0035254 |
glutamate receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035254 |
glutamate receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034237 |
protein kinase A regulatory subunit binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034237 |
protein kinase A regulatory subunit binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032591 |
dendritic spine membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032590 |
dendrite membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032279 |
asymmetric synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031698 |
beta-2 adrenergic receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031527 |
filopodium membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030346 |
protein phosphatase 2B binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030346 |
protein phosphatase 2B binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019900 |
kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010738 |
regulation of protein kinase A signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010524 |
positive regulation of calcium ion transport into cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009898 |
cytoplasmic side of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008179 |
adenylate cyclase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0008179 |
adenylate cyclase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008179 |
adenylate cyclase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007194 |
negative regulation of adenylate cyclase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007194 |
negative regulation of adenylate cyclase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003779 |
actin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620829 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006605 |
protein targeting |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-MMU-9010668 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Zhang, J et al. (2016) Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron 92 461-478 PubMed GONUTS page
- ↑ Tunquist, BJ et al. (2008) Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc. Natl. Acad. Sci. U.S.A. 105 12557-62 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Wu, CY et al. (2010) The contribution of AKAP5 in amylase secretion from mouse parotid acini. Am. J. Physiol., Cell Physiol. 298 C1151-8 PubMed GONUTS page
a
c
- GO:0045296 ! cadherin binding
- GO:0005516 ! calmodulin binding
- GO:0043624 ! cellular protein complex disassembly
- Chordata
- GO:0045163 ! clustering of voltage-gated potassium channels
- GO:0070073 ! clustering of voltage-gated calcium channels
- Craniata
- GO:0005737 ! cytoplasm
- GO:0009898 ! cytoplasmic side of plasma membrane
- GO:0005856 ! cytoskeleton
d
g
m
n
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0005886 ! plasma membrane
- GO:0070886 ! positive regulation of calcineurin-NFAT signaling cascade
- GO:0042307 ! positive regulation of protein import into nucleus
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0010524 ! positive regulation of calcium ion transport into cytosol
- GO:1903078 ! positive regulation of protein localization to plasma membrane
- GO:0045762 ! positive regulation of adenylate cyclase activity
- GO:0050775 ! positive regulation of dendrite morphogenesis
- GO:0014069 ! postsynaptic density
- GO:0099092 ! postsynaptic density, intracellular component
- GO:0032991 ! protein-containing complex
- GO:0044877 ! protein-containing complex binding
- GO:0019904 ! protein domain specific binding
- GO:0034237 ! protein kinase A regulatory subunit binding
- GO:0019901 ! protein kinase binding
- GO:0030346 ! protein phosphatase 2B binding
- GO:0006605 ! protein targeting
r
s
