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MOUSE:ADEC1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Adamdec1
Protein Name(s) ADAM DEC1

A disintegrin and metalloproteinase domain-like protein decysin-1 ADAM-like protein decysin-1

External Links
UniProt Q9R0X2
EMBL AJ242912
BC046324
CCDS CCDS49532.1
RefSeq NP_067450.1
UniGene Mm.36742
ProteinModelPortal Q9R0X2
SMR Q9R0X2
MEROPS M12.219
PhosphoSite Q9R0X2
MaxQB Q9R0X2
PaxDb Q9R0X2
PRIDE Q9R0X2
Ensembl ENSMUST00000022641
GeneID 58860
KEGG mmu:58860
UCSC uc007uls.1
CTD 27299
MGI MGI:1917650
eggNOG NOG280097
GeneTree ENSGT00760000119181
HOGENOM HOG000230883
HOVERGEN HBG106501
InParanoid Q9R0X2
KO K08634
OMA LRGYFTH
OrthoDB EOG7CNZFH
PhylomeDB Q9R0X2
TreeFam TF314733
NextBio 314412
PRO PR:Q9R0X2
Proteomes UP000000589
Bgee Q9R0X2
CleanEx MM_ADAMDEC1
ExpressionAtlas Q9R0X2
Genevestigator Q9R0X2
GO GO:0005576
GO:0004222
GO:0008270
Gene3D 3.40.390.10
InterPro IPR001762
IPR024079
IPR001590
IPR002870
Pfam PF00200
PF01562
PF01421
SMART SM00050
PROSITE PS50215
PS50214
PS00142

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045589

regulation of regulatory T cell differentiation

PMID:21057086[1]

ECO:0000315

P

Figure 1. Underexpression of the dec1 gene results in reduced T-regulatory cells, this reduction in T-cell number leads to significant growth defects in lymphatic organs. This results in susceptibility to autoimmune disease and reduction of the body's ability to fight infection and other forms of pathogenesis.

complete

part_of

GO:0005575

cellular_component

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004222

metalloendopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001590
InterPro:IPR033613

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001590

P

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024079

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0482

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Miyazaki, K et al. (2010) The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. J. Immunol. 185 7330-9 PubMed GONUTS page