MOUSE:ACOX1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Acox1 (synonyms: Acox, Paox)
Protein Name(s)	Peroxisomal acyl-coenzyme A oxidase 1 AOX Palmitoyl-CoA oxidase
External Links
UniProt	Q9R0H0
EMBL	AF006688 AB034914 AK040566 AK170217 AL669925 AL607108 AL669925 AL607108 AL607108 AL669925 AL607108 AL669925 CH466558 CH466558 BC056448
CCDS	CCDS25660.1 CCDS70354.1
RefSeq	NP_001258827.1 NP_056544.2
UniGene	Mm.356689
ProteinModelPortal	Q9R0H0
SMR	Q9R0H0
IntAct	Q9R0H0
MINT	MINT-1861412
PhosphoSite	Q9R0H0
MaxQB	Q9R0H0
PaxDb	Q9R0H0
PRIDE	Q9R0H0
Ensembl	ENSMUST00000066587 ENSMUST00000072948
GeneID	11430
KEGG	mmu:11430
UCSC	uc007mkj.1 uc007mkl.1
CTD	51
MGI	MGI:1330812
eggNOG	COG1960
GeneTree	ENSGT00530000062919
HOGENOM	HOG000181256
HOVERGEN	HBG050451
InParanoid	Q9R0H0
KO	K00232
OMA	KSANMVK
OrthoDB	EOG7D59MV
TreeFam	TF300672
Reactome	REACT_196541 REACT_198602 REACT_247416
UniPathway	UPA00661
ChiTaRS	Acox1
NextBio	278708
PRO	PR:Q9R0H0
Proteomes	UP000000589
Bgee	Q9R0H0
CleanEx	MM_ACOX1 MM_PAOX
ExpressionAtlas	Q9R0H0
Genevestigator	Q9R0H0
GO	GO:0005737 GO:0005739 GO:0005778 GO:0005777 GO:0003995 GO:0003997 GO:0071949 GO:0005504 GO:0016401 GO:0030165 GO:0006635 GO:0033540 GO:0019395 GO:0006091 GO:0055088 GO:0016559 GO:2000189 GO:0006693 GO:0007283 GO:0000038
Gene3D	1.10.540.10 2.40.110.10
InterPro	IPR029320 IPR006091 IPR012258 IPR002655 IPR009075 IPR013786 IPR009100
Pfam	PF01756 PF02770 PF14749
PIRSF	PIRSF000168
SUPFAM	SSF47203 SSF56645

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0019395	fatty acid oxidation	PMID:20195242^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:17881773^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000473) part_of:(CL:0000216)	Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000097533 UniProtKB:Q15067	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000097533 RGD:619757 RGD:628684 RGD:69245	F		Seeded From UniProt	complete
involved_in	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000097533 RGD:619757 RGD:69245 UniProtKB:Q15067 UniProtKB:Q99424	P		Seeded From UniProt	complete
enables	GO:0016401	palmitoyl-CoA oxidase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000097706 RGD:619757 UniProtKB:Q15067	F		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0032775 MGI:MGI:1330812 PANTHER:PTN000097533 RGD:619757 RGD:628684 RGD:69245 UniProtKB:O15254 UniProtKB:O65202 UniProtKB:Q15067 UniProtKB:Q5AY78 UniProtKB:Q99424 WB:WBGene00008564	C		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000097533 RGD:619757 RGD:628684 RGD:69245	F		Seeded From UniProt	complete
enables	GO:0003997	acyl-CoA oxidase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000097533 UniProtKB:O65201 UniProtKB:O65202 UniProtKB:Q15067	F		Seeded From UniProt	complete
involved_in	GO:0000038	very long-chain fatty acid metabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000097706 UniProtKB:Q15067	P		Seeded From UniProt	complete
enables	GO:0071949	FAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055088	lipid homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619757	F		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619757	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042632	cholesterol homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619757	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:23209302^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019395	fatty acid oxidation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016559	peroxisome fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
enables	GO:0016401	palmitoyl-CoA oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	F		Seeded From UniProt	complete
enables	GO:0016401	palmitoyl-CoA oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619757	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:8798738^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857811	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006693	prostaglandin metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006091	generation of precursor metabolites and energy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	C		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	PMID:12915479^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619757	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11156684^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	C		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619757	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	F		Seeded From UniProt	complete
enables	GO:0003997	acyl-CoA oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000038	very long-chain fatty acid metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15067	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	C		Seeded From UniProt	complete
involved_in	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	F		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	P		Seeded From UniProt	complete
involved_in	GO:0006693	prostaglandin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	P		Seeded From UniProt	complete
involved_in	GO:0006091	generation of precursor metabolites and energy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	F		Seeded From UniProt	complete
enables	GO:0003997	acyl-CoA oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	F		Seeded From UniProt	complete
involved_in	GO:0000038	very long-chain fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15067 ensembl:ENSP00000293217	P		Seeded From UniProt	complete
enables	GO:0003997	acyl-CoA oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002655 InterPro:IPR012258	F		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002655 InterPro:IPR012258	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012258	P		Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002655	P		Seeded From UniProt	complete
enables	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006091 InterPro:IPR009100 InterPro:IPR036250 InterPro:IPR037069	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037069	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006091 InterPro:IPR009100 InterPro:IPR036250 InterPro:IPR037069	P		Seeded From UniProt	complete
enables	GO:0071949	FAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012258	F		Seeded From UniProt	complete
enables	GO:0003997	acyl-CoA oxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.3.3.6	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9033925	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006635	fatty acid beta-oxidation	PMID:8798738^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:8798738^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003997	acyl-CoA oxidase activity	PMID:8798738^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00661	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Vluggens, A et al. (2010) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab. Invest. 90 696-708 PubMed GONUTS page
↑ Nenicu, A et al. (2007) Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol. Reprod. 77 1060-72 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Fan, CY et al. (1996) Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J. Biol. Chem. 271 24698-710 PubMed GONUTS page
↑ Brites, P et al. (2003) Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. Hum. Mol. Genet. 12 2255-67 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Grabenbauer, M et al. (2001) Detection of peroxisomal proteins and their mRNAs in serial sections of fetal and newborn mouse organs. J. Histochem. Cytochem. 49 155-64 PubMed GONUTS page

[PMID:20195242-1] Vluggens, A et al. (2010) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab. Invest. 90 696-708 PubMed GONUTS page

[PMID:17881773-2] Nenicu, A et al. (2007) Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol. Reprod. 77 1060-72 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23209302-4] Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page

[PMID:8798738-5] 5.0 ^5.1 ^5.2 ^5.3 Fan, CY et al. (1996) Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J. Biol. Chem. 271 24698-710 PubMed GONUTS page

[PMID:12915479-6] Brites, P et al. (2003) Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. Hum. Mol. Genet. 12 2255-67 PubMed GONUTS page

[PMID:14651853-7] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:11156684-8] Grabenbauer, M et al. (2001) Detection of peroxisomal proteins and their mRNAs in serial sections of fetal and newborn mouse organs. J. Histochem. Cytochem. 49 155-64 PubMed GONUTS page

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MOUSE:ACOX1

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References

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