MOUSE:ACACA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Acaca (ECO:0000312 with MGI:MGI:108451) (synonyms: Acac (ECO:0000312 with EMBL:AAS13685.1), Gm738)
Protein Name(s)	Acetyl-CoA carboxylase 1 ACC1 ACC-alpha Acetyl-CoA carboxylase 265 Biotin carboxylase
External Links
UniProt	Q5SWU9
EMBL	AY451393 AL596252 AL596447 AL596447 AL596252 AL596447 AL596447 AL596447 AL596447 AJ619664 AJ619665 AF374167 AF374168 AF374169 AF374170 BC056500
CCDS	CCDS25185.1
RefSeq	NP_579938.2 XP_006532016.1 XP_006532017.1 XP_006532018.1 XP_006532019.1 XP_006532020.1
UniGene	Mm.31374
ProteinModelPortal	Q5SWU9
SMR	Q5SWU9
BioGrid	223322
DIP	DIP-32276N
IntAct	Q5SWU9
MINT	MINT-4091386
BindingDB	Q5SWU9
ChEMBL	CHEMBL3086
PhosphoSite	Q5SWU9
MaxQB	Q5SWU9
PaxDb	Q5SWU9
PRIDE	Q5SWU9
Ensembl	ENSMUST00000020843 ENSMUST00000103201 ENSMUST00000133811
GeneID	107476
KEGG	mmu:107476
UCSC	uc007kql.1
CTD	31
MGI	MGI:108451
eggNOG	COG0511
GeneTree	ENSGT00550000074703
HOVERGEN	HBG005371
InParanoid	Q5SWU9
KO	K11262
OMA	GESGCIH
OrthoDB	EOG7HXCPW
PhylomeDB	Q5SWU9
TreeFam	TF300061
Reactome	REACT_189100 REACT_198969 REACT_206176 REACT_231395 REACT_255695 REACT_257268
UniPathway	UPA00655
NextBio	358872
PRO	PR:Q5SWU9
Proteomes	UP000000589
Bgee	Q5SWU9
CleanEx	MM_ACACA
ExpressionAtlas	Q5SWU9
Genevestigator	Q5SWU9
GO	GO:0005829 GO:0070062 GO:0005739 GO:0003989 GO:0005524 GO:0004075 GO:0046872 GO:0006084 GO:0006633 GO:0055088 GO:0006629 GO:2001295 GO:0044268 GO:0051289 GO:0001894
Gene3D	3.30.1490.20 3.30.470.20 3.40.50.20 3.90.226.10
InterPro	IPR013537 IPR011761 IPR013815 IPR013816 IPR001882 IPR011764 IPR005482 IPR000089 IPR005481 IPR000022 IPR005479 IPR029045 IPR011763 IPR011762 IPR016185 IPR011054 IPR011053
Pfam	PF08326 PF02785 PF00364 PF01039 PF00289 PF02786
SMART	SM00878
SUPFAM	SSF51230 SSF51246 SSF52096 SSF52440
PROSITE	PS50975 PS50979 PS00188 PS50968 PS50989 PS50980 PS00866 PS00867

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
incorrect (CACAO)	GO:0055088	lipid homeostasis	PMID:20139635^[1]	ECO:0000304			P		intro Liver specific ACC1 knockout mice show decreased hepatic triglyceride accumulation	complete
incorrect (CACAO)	GO:0046890	regulation of lipid biosynthetic process	PMID:20139635^[1]	ECO:0000304			P		intro ...... ACC1 plays a crucial role in the regulation of lipogenesis	complete
involved_in	GO:0051289	protein homotetramerization	PMID:20952656^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	PMID:20952656^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006084	acetyl-CoA metabolic process	PMID:20952656^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:20952656^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	PMID:20952656^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071380	cellular response to prostaglandin E stimulus	PMID:23479225^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055088	lipid homeostasis	PMID:17210641^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700954	P	has_participant:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13085	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621248	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019538	protein metabolic process	PMID:17210641^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700954 MGI:MGI:3700955	P	has_participant:(EMAPA:35690)	Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13085	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014070	response to organic cyclic compound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621248	P		Seeded From UniProt	complete
enables	GO:0009374	biotin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621248	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006633	fatty acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621248	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:17210641^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700954	P	has_participant:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13085	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	PMID:8954960^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621248	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001894	tissue homeostasis	PMID:17210641^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3700954 MGI:MGI:3700955	P	occurs_in:(EMAPA:35690)	Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13085	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13085 ensembl:ENSP00000483300	F		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13085 ensembl:ENSP00000483300	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13085 ensembl:ENSP00000483300	C		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13085 ensembl:ENSP00000483300	C		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013537	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005479 InterPro:IPR011761 InterPro:IPR013537 InterPro:IPR013815	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013537	P		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011763	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011761	F		Seeded From UniProt	complete
enables	GO:0003989	acetyl-CoA carboxylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.4.1.2	F		Seeded From UniProt	complete
enables	GO:0004075	biotin carboxylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.3.4.14	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021 UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021 UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:2001295	malonyl-CoA biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00655	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhao, LF et al. (2010) Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr. J. 57 317-24 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Colbert, CL et al. (2010) Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 18820-5 PubMed GONUTS page
↑ Través, PG et al. (2013) Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J. Immunol. 190 4226-35 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Harada, N et al. (2007) Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol. Cell. Biol. 27 1881-8 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Zhang, S & Kim, KH (1996) Acetyl-CoA carboxylase is essential for nutrient-induced insulin secretion. Biochem. Biophys. Res. Commun. 229 701-5 PubMed GONUTS page

[PMID:20139635-1] 1.0 ^1.1 Zhao, LF et al. (2010) Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr. J. 57 317-24 PubMed GONUTS page

[PMID:20952656-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Colbert, CL et al. (2010) Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc. Natl. Acad. Sci. U.S.A. 107 18820-5 PubMed GONUTS page

[PMID:23479225-3] Través, PG et al. (2013) Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses. J. Immunol. 190 4226-35 PubMed GONUTS page

[PMID:17210641-4] 4.0 ^4.1 ^4.2 ^4.3 Harada, N et al. (2007) Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol. Cell. Biol. 27 1881-8 PubMed GONUTS page

[PMID:18614015-5] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:8954960-6] Zhang, S & Kim, KH (1996) Acetyl-CoA carboxylase is essential for nutrient-induced insulin secretion. Biochem. Biophys. Res. Commun. 229 701-5 PubMed GONUTS page

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MOUSE:ACACA

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