MOUSE:ABCG5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Abcg5
Protein Name(s)	ATP-binding cassette sub-family G member 5 Sterolin-1
External Links
UniProt	Q99PE8
EMBL	AF312713
CCDS	CCDS29001.1
RefSeq	NP_114090.1
UniGene	Mm.289590
ProteinModelPortal	Q99PE8
SMR	Q99PE8
PhosphoSite	Q99PE8
PRIDE	Q99PE8
Ensembl	ENSMUST00000066175
GeneID	27409
KEGG	mmu:27409
UCSC	uc008dsz.1
CTD	64240
MGI	MGI:1351659
eggNOG	COG1131
GeneTree	ENSGT00740000114855
HOGENOM	HOG000033763
HOVERGEN	HBG050443
InParanoid	Q99PE8
KO	K05683
OMA	SQGIQFI
OrthoDB	EOG7QNVKG
PhylomeDB	Q99PE8
TreeFam	TF105212
Reactome	REACT_197984 REACT_230613
NextBio	305422
PRO	PR:Q99PE8
Proteomes	UP000000589
Bgee	Q99PE8
ExpressionAtlas	Q99PE8
Genevestigator	Q99PE8
GO	GO:0045177 GO:0016324 GO:0016021 GO:0016020 GO:0005524 GO:0016887 GO:0017127 GO:0033344 GO:0042632 GO:0007588 GO:0030299 GO:0045796 GO:0010949 GO:0042493 GO:0010212 GO:0007584
Gene3D	3.40.50.300
InterPro	IPR003593 IPR013525 IPR003439 IPR017871 IPR027417
Pfam	PF01061 PF00005
SMART	SM00382
SUPFAM	SSF52540
PROSITE	PS00211 PS50893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0046982	protein heterodimerization activity	PMID:12208867^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:12208867^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:12208867^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:14504269^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:14504269^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030299	intestinal cholesterol absorption	PMID:12208868^[3]	ECO:0000305	curator inference used in manual assertion	GO:0017127	P		Seeded From UniProt	complete
contributes_to	GO:0017127	cholesterol transporter activity	PMID:14504269^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:14504269^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007588	excretion	PMID:14504269^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003996 FB:FBgn0020762 PANTHER:PTN000443108 TAIR:locus:2084081	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002710457 UniProtKB:Q9H222	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020762 PANTHER:PTN000443108 TAIR:locus:2016089 UniProtKB:Q9H221 UniProtKB:Q9H222	F		Seeded From UniProt	complete
contributes_to	GO:0017127	cholesterol transporter activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351659 PANTHER:PTN002710457 UniProtKB:Q9H222	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000443108 PomBase:SPCC18B5.01c RGD:631345 SGD:S000002418 SGD:S000005537 SGD:S000005679 SGD:S000005855 SGD:S000005979 TAIR:locus:2009680 TAIR:locus:2016089 TAIR:locus:2019693 TAIR:locus:2028656 TAIR:locus:2030898 TAIR:locus:2037703 TAIR:locus:2039523 TAIR:locus:2039682 TAIR:locus:2044893 TAIR:locus:2046203 TAIR:locus:2049867 TAIR:locus:2084081 TAIR:locus:2090009 TAIR:locus:2100514 TAIR:locus:2124029 TAIR:locus:2144133 TAIR:locus:2196593 UniProtKB:A0A1D8PCM6 UniProtKB:A0A1D8PE84 UniProtKB:A0A1D8PQ95 UniProtKB:E9RBG1 UniProtKB:Q4X006 UniProtKB:Q8H8V7 UniProtKB:Q94A18 UniProtKB:Q9UNQ0	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045796	negative regulation of intestinal cholesterol absorption	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:15040800^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:32874)	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	C		Seeded From UniProt	complete
part_of	GO:0043190	ATP-binding cassette (ABC) transporter complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042632	cholesterol homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033344	cholesterol efflux	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	P		Seeded From UniProt	complete
contributes_to	GO:0017127	cholesterol transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	F		Seeded From UniProt	complete
contributes_to	GO:0016887	ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15040800^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010949	negative regulation of intestinal phytosterol absorption	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007588	excretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	P		Seeded From UniProt	complete
contributes_to	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H222	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99PE7 ensembl:ENSRNOP00000007174	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99PE7 ensembl:ENSRNOP00000007174	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99PE7 ensembl:ENSRNOP00000007174	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	F		Seeded From UniProt	complete
involved_in	GO:0045796	negative regulation of intestinal cholesterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	C		Seeded From UniProt	complete
part_of	GO:0043190	ATP-binding cassette (ABC) transporter complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	C		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	F		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	C		Seeded From UniProt	complete
involved_in	GO:0010949	negative regulation of intestinal phytosterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	P		Seeded From UniProt	complete
involved_in	GO:0007588	excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H222 ensembl:ENSP00000260645	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013525	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Graf, GA et al. (2002) Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J. Clin. Invest. 110 659-69 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Graf, GA et al. (2003) ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J. Biol. Chem. 278 48275-82 PubMed GONUTS page
↑ Yu, L et al. (2002) Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110 671-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Klett, EL et al. (2004) A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med 2 5 PubMed GONUTS page

[PMID:12208867-1] 1.0 ^1.1 ^1.2 Graf, GA et al. (2002) Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J. Clin. Invest. 110 659-69 PubMed GONUTS page

[PMID:14504269-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Graf, GA et al. (2003) ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J. Biol. Chem. 278 48275-82 PubMed GONUTS page

[PMID:12208868-3] Yu, L et al. (2002) Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110 671-80 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15040800-5] 5.0 ^5.1 Klett, EL et al. (2004) A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med 2 5 PubMed GONUTS page

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MOUSE:ABCG5

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