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MOUSE:1433F

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ywhah
Protein Name(s) 14-3-3 protein eta
External Links
UniProt P68510
EMBL U57311
D87661
AF077002
AB063572
AK077596
AK149224
AK168520
AK169035
AK169189
BC008187
BC061497
CCDS CCDS19198.1
RefSeq NP_035868.1
UniGene Mm.332314
ProteinModelPortal P68510
SMR P68510
BioGrid 204621
IntAct P68510
MINT MINT-198030
PhosphoSite P68510
UCD-2DPAGE P68510
MaxQB P68510
PaxDb P68510
PRIDE P68510
Ensembl ENSMUST00000019109
GeneID 22629
KEGG mmu:22629
UCSC uc008xag.2
CTD 7533
MGI MGI:109194
eggNOG COG5040
GeneTree ENSGT00760000119116
HOGENOM HOG000240379
HOVERGEN HBG050423
InParanoid P68510
KO K16198
OMA APEQACQ
OrthoDB EOG7HHWT3
PhylomeDB P68510
TreeFam TF102003
Reactome REACT_199054
ChiTaRS Ywhah
NextBio 302995
PRO PR:P68510
Proteomes UP000000589
Bgee P68510
Genevestigator P68510
GO GO:0005737
GO:0030659
GO:0005829
GO:0070062
GO:0014704
GO:0005886
GO:0003779
GO:0035259
GO:0044325
GO:0019904
GO:0017080
GO:0007010
GO:0006713
GO:0042921
GO:0006886
GO:0086010
GO:0043066
GO:0050774
GO:0045893
GO:0007088
GO:2000649
GO:0002028
GO:0021762
InterPro IPR000308
IPR023409
IPR023410
PANTHER PTHR18860
Pfam PF00244
PIRSF PIRSF000868
PRINTS PR00305
SMART SM00101
SUPFAM SSF48445
PROSITE PS00796
PS00797

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:12176032[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007088

regulation of mitotic nuclear division

PMID:12176032[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007010

cytoskeleton organization

PMID:12176032[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12176032[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:12176032[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000649

regulation of sodium ion transmembrane transporter activity

PMID:16728661[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

involved_in

GO:0086010

membrane depolarization during action potential

PMID:16728661[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

PMID:16728661[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14524

F

Seeded From UniProt

complete

enables

GO:0017080

sodium channel regulator activity

PMID:16728661[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

part_of

GO:0014704

intercalated disc

PMID:16728661[2]

ECO:0000305

curator inference used in manual assertion

GO:0044325

C

Seeded From UniProt

complete

involved_in

GO:0002028

regulation of sodium ion transport

PMID:16728661[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

involved_in

GO:0042921

glucocorticoid receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

enables

GO:0035259

glucocorticoid receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

involved_in

GO:0006713

glucocorticoid catabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000649

regulation of sodium ion transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0086010

membrane depolarization during action potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050774

negative regulation of dendrite morphogenesis

PMID:9738002[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3978

C

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042921

glucocorticoid receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

enables

GO:0035259

glucocorticoid receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:12446771[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

enables

GO:0017080

sodium channel regulator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006886

intracellular protein transport

PMID:12446771[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006713

glucocorticoid catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9738002[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002028

regulation of sodium ion transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q04917

P

Seeded From UniProt

complete

involved_in

GO:2000649

regulation of sodium ion transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

P

Seeded From UniProt

complete

involved_in

GO:0086010

membrane depolarization during action potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

P

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

F

Seeded From UniProt

complete

involved_in

GO:0042921

glucocorticoid receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

F

Seeded From UniProt

complete

enables

GO:0035259

glucocorticoid receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

F

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

F

Seeded From UniProt

complete

enables

GO:0017080

sodium channel regulator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

F

Seeded From UniProt

complete

involved_in

GO:0006713

glucocorticoid catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

C

Seeded From UniProt

complete

involved_in

GO:0002028

regulation of sodium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q04917
ensembl:ENSP00000248975

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000308

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-MMU-1454713
Reactome:R-MMU-1445145

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Chen, XQ & Yu, AC (2002) The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes. Biochem. Biophys. Res. Commun. 296 657-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Allouis, M et al. (2006) 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. Circ. Res. 98 1538-46 PubMed GONUTS page
  3. 3.0 3.1 Tang, SJ et al. (1998) Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins. J. Biol. Chem. 273 25356-63 PubMed GONUTS page
  4. 4.0 4.1 Eilers, AL et al. (2002) A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. Mol. Cell. Biol. 22 8514-26 PubMed GONUTS page