MOUSE:1433F

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ywhah
Protein Name(s)	14-3-3 protein eta
External Links
UniProt	P68510
EMBL	U57311 D87661 AF077002 AB063572 AK077596 AK149224 AK168520 AK169035 AK169189 BC008187 BC061497
CCDS	CCDS19198.1
RefSeq	NP_035868.1
UniGene	Mm.332314
ProteinModelPortal	P68510
SMR	P68510
BioGrid	204621
IntAct	P68510
MINT	MINT-198030
PhosphoSite	P68510
UCD-2DPAGE	P68510
MaxQB	P68510
PaxDb	P68510
PRIDE	P68510
Ensembl	ENSMUST00000019109
GeneID	22629
KEGG	mmu:22629
UCSC	uc008xag.2
CTD	7533
MGI	MGI:109194
eggNOG	COG5040
GeneTree	ENSGT00760000119116
HOGENOM	HOG000240379
HOVERGEN	HBG050423
InParanoid	P68510
KO	K16198
OMA	APEQACQ
OrthoDB	EOG7HHWT3
PhylomeDB	P68510
TreeFam	TF102003
Reactome	REACT_199054
ChiTaRS	Ywhah
NextBio	302995
PRO	PR:P68510
Proteomes	UP000000589
Bgee	P68510
Genevestigator	P68510
GO	GO:0005737 GO:0030659 GO:0005829 GO:0070062 GO:0014704 GO:0005886 GO:0003779 GO:0035259 GO:0044325 GO:0019904 GO:0017080 GO:0007010 GO:0006713 GO:0042921 GO:0006886 GO:0086010 GO:0043066 GO:0050774 GO:0045893 GO:0007088 GO:2000649 GO:0002028 GO:0021762
InterPro	IPR000308 IPR023409 IPR023410
PANTHER	PTHR18860
Pfam	PF00244
PIRSF	PIRSF000868
PRINTS	PR00305
SMART	SM00101
SUPFAM	SSF48445
PROSITE	PS00796 PS00797

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12176032^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:12176032^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:12176032^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12176032^[1]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:12176032^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:16728661^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
involved_in	GO:0086010	membrane depolarization during action potential	PMID:16728661^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:16728661^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14524	F	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:16728661^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:16728661^[2]	ECO:0000305	curator inference used in manual assertion	GO:0044325	C	Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	PMID:16728661^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
involved_in	GO:0006713	glucocorticoid catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000649	regulation of sodium ion transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0086010	membrane depolarization during action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050774	negative regulation of dendrite morphogenesis	PMID:9738002^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3978	C	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042921	glucocorticoid receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:12446771^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006886	intracellular protein transport	PMID:12446771^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006713	glucocorticoid catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9738002^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002028	regulation of sodium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04917	P	Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	P	Seeded From UniProt	complete
involved_in	GO:0086010	membrane depolarization during action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	P	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	F	Seeded From UniProt	complete
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	F	Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	F	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	F	Seeded From UniProt	complete
involved_in	GO:0006713	glucocorticoid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	C	Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04917 ensembl:ENSP00000248975	P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000308	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-1454713 Reactome:R-MMU-1445145	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Chen, XQ & Yu, AC (2002) The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes. Biochem. Biophys. Res. Commun. 296 657-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Allouis, M et al. (2006) 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. Circ. Res. 98 1538-46 PubMed GONUTS page
↑ ^3.0 ^3.1 Tang, SJ et al. (1998) Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins. J. Biol. Chem. 273 25356-63 PubMed GONUTS page
↑ ^4.0 ^4.1 Eilers, AL et al. (2002) A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. Mol. Cell. Biol. 22 8514-26 PubMed GONUTS page

[PMID:12176032-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Chen, XQ & Yu, AC (2002) The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes. Biochem. Biophys. Res. Commun. 296 657-63 PubMed GONUTS page

[PMID:16728661-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Allouis, M et al. (2006) 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. Circ. Res. 98 1538-46 PubMed GONUTS page

[PMID:9738002-3] 3.0 ^3.1 Tang, SJ et al. (1998) Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins. J. Biol. Chem. 273 25356-63 PubMed GONUTS page

[PMID:12446771-4] 4.0 ^4.1 Eilers, AL et al. (2002) A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. Mol. Cell. Biol. 22 8514-26 PubMed GONUTS page

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MOUSE:1433F

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