MESAU:PYR1

Species (Taxon ID)	Mesocricetus auratus (Golden hamster). (10036)
Gene Name(s)	CAD
Protein Name(s)	CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase
External Links
UniProt	P08955
EMBL	J05503 M28866 M60078 M11242 M23652 M21927
PIR	A38653
ProteinModelPortal	P08955
MEROPS	M38.972
PRIDE	P08955
HOVERGEN	HBG000279
BRENDA	3.5.2.3
SABIO-RK	P08955
UniPathway	UPA00070 UPA00070 UPA00070
GO	GO:0005737 GO:0005829 GO:0005739 GO:0016363 GO:0005634 GO:0070335 GO:0004070 GO:0005524 GO:0004088 GO:0004151 GO:0004672 GO:0002134 GO:0008270 GO:0006207 GO:0044205 GO:0070409 GO:0006543 GO:0006541 GO:0018107 GO:0046777
Gene3D	1.10.1030.10 3.30.1490.20 3.30.470.20 3.40.50.1370 3.40.50.1380 3.40.50.20 3.40.50.880 3.50.30.20
HAMAP	MF_00001 MF_01209
InterPro	IPR006132 IPR006130 IPR002082 IPR006131 IPR011761 IPR013815 IPR013816 IPR006275 IPR005481 IPR005480 IPR006274 IPR002474 IPR005479 IPR005483 IPR029062 IPR002195 IPR017926 IPR011059 IPR011607 IPR016185
Pfam	PF00289 PF02786 PF02787 PF00988 PF00117 PF02142 PF00185 PF02729
PRINTS	PR00100 PR00101 PR00098
SMART	SM01096 SM01097 SM00851
SUPFAM	SSF48108 SSF51338 SSF52021 SSF52317 SSF52335 SSF52440 SSF53671
TIGRFAMs	TIGR00670 TIGR01369 TIGR01368
PROSITE	PS50975 PS00097 PS00866 PS00867 PS00482 PS00483 PS51273

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0070335	aspartate binding	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:15890648^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15890648^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15890648^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27708	F	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	PMID:19472^[1]	ECO:0000305	curator inference used in manual assertion	GO:0004070	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15890648^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15890648^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15890648^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	PMID:19472^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0002134	UTP binding	PMID:11986331^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002082	F	Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006274	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005479 InterPro:IPR011761 InterPro:IPR013815	F	Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002082 InterPro:IPR006274	P	Seeded From UniProt	complete
involved_in	GO:0006520	cellular amino acid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006130 InterPro:IPR006131 InterPro:IPR006132 InterPro:IPR036901	P	Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006274	P	Seeded From UniProt	complete
involved_in	GO:0006807	nitrogen compound metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005483 InterPro:IPR006275	P	Seeded From UniProt	complete
enables	GO:0016597	amino acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006130 InterPro:IPR006131 InterPro:IPR036901	F	Seeded From UniProt	complete
enables	GO:0016743	carboxyl- or carbamoyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006130 InterPro:IPR006131 InterPro:IPR006132 InterPro:IPR036901	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006680	F	Seeded From UniProt	complete
enables	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011059	F	Seeded From UniProt	complete
enables	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002195	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011761	F	Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.3.5.5	F	Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.3.2	F	Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.2.3	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511 UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511 UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F	Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0315	P	Seeded From UniProt	complete
involved_in	GO:0006221	pyrimidine nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0665	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0044205	'de novo' UMP biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00070	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Coleman, PF et al. (1977) Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides. J. Biol. Chem. 252 6379-85 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Sigoillot, FD et al. (2002) Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis. J. Biol. Chem. 277 24809-17 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sigoillot, FD et al. (2005) Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J. Biol. Chem. 280 25611-20 PubMed GONUTS page

[PMID:19472-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Coleman, PF et al. (1977) Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides. J. Biol. Chem. 252 6379-85 PubMed GONUTS page

[PMID:11986331-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Sigoillot, FD et al. (2002) Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis. J. Biol. Chem. 277 24809-17 PubMed GONUTS page

[PMID:15890648-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Sigoillot, FD et al. (2005) Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J. Biol. Chem. 280 25611-20 PubMed GONUTS page

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MESAU:PYR1

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