LEIMA:DRTS

Species (Taxon ID)	Leishmania major. (5664)
Gene Name(s)	No Information Provided.
Protein Name(s)	Bifunctional dihydrofolate reductase-thymidylate synthase DHFR-TS Dihydrofolate reductase Thymidylate synthase
External Links
UniProt	P07382
EMBL	M12734 M14330 X51733 FR796402
PIR	A23403
RefSeq	XP_001680857.1
ProteinModelPortal	P07382
SMR	P07382
BindingDB	P07382
ChEMBL	CHEMBL4614
GeneID	5649109
KEGG	lma:LMJF_06_0860
HOGENOM	HOG000257901
InParanoid	P07382
KO	K13998
OMA	LEFEICK
UniPathway	UPA00077
Proteomes	UP000000542
GO	GO:0004146 GO:0004799 GO:0006231 GO:0006545 GO:0006730 GO:0046654
Gene3D	3.30.572.10 3.40.430.10
HAMAP	MF_00008
InterPro	IPR024072 IPR012262 IPR017925 IPR001796 IPR023451 IPR000398 IPR020940
Pfam	PF00186 PF00303
PIRSF	PIRSF000389
PRINTS	PR00108
SUPFAM	SSF53597 SSF55831
TIGRFAMs	TIGR03284
PROSITE	PS00075 PS51330 PS00091

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006231	dTMP biosynthetic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11002 PANTHER:PTN000167391 PomBase:SPAC15E1.04 RGD:3921 SGD:S000005600 UniProtKB:P04818 UniProtKB:P9WFR9 WB:WBGene00022455 ZFIN:ZDB-GENE-040426-59	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11002 PANTHER:PTN000167391 TAIR:locus:2042649	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002610699 RGD:3921 TAIR:locus:2139544 UniProtKB:P04818	C		Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11002 PANTHER:PTN000167391 PomBase:SPAC15E1.04 RGD:3921 SGD:S000005600 UniProtKB:P04818 UniProtKB:P9WFR9 WB:WBGene00022455 ZFIN:ZDB-GENE-040426-59	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000101	ECO:0000266	sequence orthology evidence used in manual assertion	GeneDB:Tb927.7.5480	C		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012262 InterPro:IPR017925	F		Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR012262 InterPro:IPR020940	F		Seeded From UniProt	complete
involved_in	GO:0006231	dTMP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR020940	P		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012262	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012262 InterPro:IPR017925	P		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.3	F		Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.45	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0009165	nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0545	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00077	P		Seeded From UniProt	complete
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