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LASSJ:NCAP
Contents
| Species (Taxon ID) | Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV). (11622) | |
| Gene Name(s) | N | |
| Protein Name(s) | Nucleoprotein
Nucleocapsid protein Protein N | |
| External Links | ||
| UniProt | P13699 | |
| EMBL | J04324 | |
| PIR | A31294 | |
| RefSeq | NP_694869.1 | |
| PDB | 3MWP 3MWT 3MX2 3MX5 3Q7B 3Q7C 4FVU 4G9Z 4GV3 4GV6 4GV9 | |
| PDBsum | 3MWP 3MWT 3MX2 3MX5 3Q7B 3Q7C 4FVU 4G9Z 4GV3 4GV6 4GV9 | |
| DIP | DIP-59217N | |
| GeneID | 956584 | |
| EvolutionaryTrace | P13699 | |
| Proteomes | UP000002473 | |
| GO | GO:0019029 GO:0030430 GO:0019013 GO:0008408 GO:0046872 GO:0003723 GO:0030683 GO:0090305 GO:0039724 | |
| InterPro | IPR000229 IPR001680 | |
| Pfam | PF00843 | |
| PIRSF | PIRSF004029 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008408 |
3'-5' exonuclease activity |
ECO:0000315 |
F |
Fig. 3 |
complete | |||||
| GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000315 |
P |
Fig. 5 |
complete | |||||
|
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039696 |
RNA-templated viral transcription |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039689 |
negative stranded viral RNA replication |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008408 |
3'-5' exonuclease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008408 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019013 |
viral nucleocapsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019029 |
helical viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039689 |
negative stranded viral RNA replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019013 |
viral nucleocapsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039724 |
suppression by virus of host IKBKE activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039696 |
RNA-templated viral transcription |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000775821 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039724 |
suppression by virus of host IKBKE activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019029 |
helical viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019013 |
viral nucleocapsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Hastie, KM et al. (2011) Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proc. Natl. Acad. Sci. U.S.A. 108 2396-401 PubMed GONUTS page
- ↑ Qi, X et al. (2010) Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature 468 779-83 PubMed GONUTS page
h
o
s
- ssRNA negative-strand viruses
- GO:0039724 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
- GO:0039548 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
