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LAMBD:SPAN1
Contents
| Species (Taxon ID) | Escherichia phage lambda (Bacteriophage lambda). (10710) | |
| Gene Name(s) | Rz | |
| Protein Name(s) | Spanin, inner membrane subunit
i-spanin Lysis protein Rz | |
| External Links | ||
| UniProt | P00726 | |
| EMBL | J02459 | |
| PIR | A94614 | |
| RefSeq | NP_040646.1 | |
| TCDB | 1.M.1.1.1 | |
| PRIDE | P00726 | |
| GeneID | 2703481 | |
| KEGG | vg:2703481 | |
| KO | K14744 | |
| OrthoDB | VOG0900010C | |
| Proteomes | UP000001711 | |
| GO | GO:0020002 GO:0016021 GO:0019835 GO:0019076 | |
| InterPro | IPR004929 | |
| Pfam | PF03245 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042597 |
periplasmic space |
ECO:0000314 |
C |
Figure 2. "Purification of the Rz and Rz1 periplasmic domains" |
complete | |||||
| GO:0061025 |
membrane fusion |
ECO:0007122 |
in vitro assay evidence used in manual assertion |
P |
Figure 3C shows the spheroplast fusion assay in lambda, in which inner membrane protein Rz and outer membrane protein Rz1 fuse together during the last step of the lytic stage. Green GFP displays Rz and red mCherry displays Rz1. |
complete | ||||
| GO:0090680 |
disruption by virus of host outer membrane |
ECO:0000315 |
P |
Fig. 2a,b,e and f demonstrates that Rz, a spanin inner membrane subunit of the Escherichia phage lambda is essential part of the RzRz1 spanin complex, which rapidly lyses the E. coli bacterium. When mutant was observed, the outer membrane was not ruptured, preventing lysis of the bacterium. |
complete | |||||
|
involved_in |
GO:0019076 |
viral release from host cell |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019835 |
cytolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-1030 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019835 |
cytolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Berry, J et al. (2010) The lambda spanin components Rz and Rz1 undergo tertiary and quaternary rearrangements upon complex formation. Protein Sci. 19 1967-77 PubMed GONUTS page
- ↑ Rajaure, M et al. (2015) Membrane fusion during phage lysis. Proc. Natl. Acad. Sci. U.S.A. 112 5497-502 PubMed GONUTS page
- ↑ Berry, J et al. (2012) The spanin complex is essential for lambda lysis. J. Bacteriol. 194 5667-74 PubMed GONUTS page
