LACCA:DYR

Species (Taxon ID)	Lactobacillus casei. (1582)
Gene Name(s)	folA (synonyms: dhfR)
Protein Name(s)	Dihydrofolate reductase
External Links
UniProt	P00381
EMBL	M10922
PIR	A24036
PDB	1AO8 1BZF 1DIS 1DIU 1LUD 2HM9 2HQP 2L28 2LF1 3DFR
PDBsum	1AO8 1BZF 1DIS 1DIU 1LUD 2HM9 2HQP 2L28 2LF1 3DFR
ProteinModelPortal	P00381
SMR	P00381
BindingDB	P00381
ChEMBL	CHEMBL2902
BRENDA	1.5.1.3
SABIO-RK	P00381
UniPathway	UPA00077
EvolutionaryTrace	P00381
GO	GO:0004146 GO:0050661 GO:0006545 GO:0009165 GO:0006730 GO:0046677 GO:0031427 GO:0046654
Gene3D	3.40.430.10
InterPro	IPR012259 IPR024072 IPR017925 IPR001796
Pfam	PF00186
PIRSF	PIRSF000194
PRINTS	PR00070
SUPFAM	SSF53597
PROSITE	PS00075 PS51330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050661	NADP binding	PMID:6815179	ECO:0000314			F		Using crystallography, scientists determined that when NADPH binds to dihydrofolate reductase, the enzyme:substrate complex geometry stands out. Nicotinamide interacts with 3 oxygen atoms and 3 hydrogen atoms in this very polar environment.	complete CACAO 11422
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012259 InterPro:IPR017925	F		Seeded From UniProt	complete
involved_in	GO:0006545	glycine biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012259	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012259	P		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012259	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012259 InterPro:IPR017925	P		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.3	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0031427	response to methotrexate	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0487	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0046	P		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00077	P		Seeded From UniProt	complete
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References

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