I96A0:PB2

Species (Taxon ID)	Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotypeGs/Gd). (93838)
Gene Name(s)	PB2
Protein Name(s)	Polymerase basic protein 2 RNA-directed RNA polymerase subunit P3
External Links
UniProt	Q9Q0V1
EMBL	AF144300
RefSeq	YP_308664.1
ProteinModelPortal	Q9Q0V1
SMR	Q9Q0V1
IntAct	Q9Q0V1
MINT	MINT-8407675
GeneID	3654615
Proteomes	UP000006679
GO	GO:0033650 GO:0042025 GO:0019012 GO:0003723 GO:0003968 GO:0006370 GO:0075526 GO:0039545 GO:0039523 GO:0006351
InterPro	IPR001591
Pfam	PF00604
ProDom	PD001667

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003968	RNA-directed RNA polymerase activity	PMID:21431346	ECO:0000316			F		The polymorphic amino acid sites in the protein sequences of the Egyptian human and avian strains in comparison to the equine isolate were examined, as was the distribution of the alternative residues among strains classified as virulent or nonvirulent (Table 2), such residues having functional significance for virulence in H5N1. H5N1 influenza virus isolated from equines and humans in Egypt contained most of the amino acids specific to the avian virus, where the PB2 contained two avian virus-like amino acids (alanine, A 661 and lysine, K 702). These two amino acids are located in the domain of the PB2 gene, which is believed to be responsible for interaction with other polymerase components [30]. One genetic indicator of adaptation and efficient replication in humans is the E627K substitution in the PB2 protein [34, 37].	Missing: with/from
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001591 InterPro:IPR037258	F		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037258	P		Seeded From UniProt	complete
involved_in	GO:0039694	viral RNA genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001591	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	C		Seeded From UniProt	complete
involved_in	GO:0075526	cap snatching	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	F		Seeded From UniProt	complete
involved_in	GO:0006370	7-methylguanosine mRNA capping	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P		Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	F		Seeded From UniProt	complete
involved_in	GO:0019083	viral transcription	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P		Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1104	P		Seeded From UniProt	complete
involved_in	GO:0019083	viral transcription	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1195	P		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C		Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C		Seeded From UniProt	complete
involved_in	GO:0075526	cap snatching	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1157	P		Seeded From UniProt	complete
involved_in	GO:0006370	7-methylguanosine mRNA capping	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0506	P		Seeded From UniProt	complete
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