I33A0:PB2

Species (Taxon ID)	Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)). (381518)
Gene Name(s)	PB2
Protein Name(s)	Polymerase basic protein 2 RNA-directed RNA polymerase subunit P3
External Links
UniProt	P03427
EMBL	J02179
ProteinModelPortal	P03427
SMR	P03427
IntAct	P03427
MINT	MINT-8081619
Proteomes	UP000000834
GO	GO:0033650 GO:0042025 GO:0019012 GO:0003723 GO:0003968 GO:0006370 GO:0075526 GO:0039545 GO:0039523 GO:0006351
InterPro	IPR001591
Pfam	PF00604
ProDom	PD001667

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0033650	host cell mitochondrion	PMID:27440905^[1]	ECO:0000314			C	Seen in figure 4, PB2 is imported into the mitochondrial matrix of the host. Polymerase basic protein 2 Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))	complete CACAO 12726
involved_in	GO:0039689	negative stranded viral RNA replication	PMID:2214032^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	PMID:1985200^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001591 InterPro:IPR037258	F	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037258	P	Seeded From UniProt	complete
involved_in	GO:0039694	viral RNA genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001591	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	F	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	C	Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	C	Seeded From UniProt	complete
part_of	GO:0033650	host cell mitochondrion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	C	Seeded From UniProt	complete
involved_in	GO:0075526	cap snatching	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P	Seeded From UniProt	complete
involved_in	GO:0006370	7-methylguanosine mRNA capping	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P	Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	F	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P	Seeded From UniProt	complete
involved_in	GO:0019083	viral transcription	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P	Seeded From UniProt	complete
involved_in	GO:0039545	suppression by virus of host MAVS activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523929	P	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C	Seeded From UniProt	complete
involved_in	GO:0006370	7-methylguanosine mRNA capping	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0506	P	Seeded From UniProt	complete
part_of	GO:0033650	host cell mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1045 UniProtKB-SubCell:SL-0407	C	Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P	Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
involved_in	GO:0019083	viral transcription	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1195	P	Seeded From UniProt	complete
involved_in	GO:0075526	cap snatching	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1157	P	Seeded From UniProt	complete
involved_in	GO:0039545	suppression by virus of host MAVS activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1097	P	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1104	P	Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P	Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Long, JC & Fodor, E (2016) The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix. J. Virol. 90 8729-38 PubMed GONUTS page
↑ Huang, TS et al. (1990) Determination of influenza virus proteins required for genome replication. J. Virol. 64 5669-73 PubMed GONUTS page
↑ Mukaigawa, J & Nayak, DP (1991) Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. J. Virol. 65 245-53 PubMed GONUTS page

[PMID:27440905-1] Long, JC & Fodor, E (2016) The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix. J. Virol. 90 8729-38 PubMed GONUTS page

[PMID:2214032-2] Huang, TS et al. (1990) Determination of influenza virus proteins required for genome replication. J. Virol. 64 5669-73 PubMed GONUTS page

[PMID:1985200-3] Mukaigawa, J & Nayak, DP (1991) Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. J. Virol. 65 245-53 PubMed GONUTS page

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I33A0:PB2

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