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I33A0:PB2

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Species (Taxon ID) Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)). (381518)
Gene Name(s) PB2
Protein Name(s) Polymerase basic protein 2

RNA-directed RNA polymerase subunit P3

External Links
UniProt P03427
EMBL J02179
ProteinModelPortal P03427
SMR P03427
IntAct P03427
MINT MINT-8081619
Proteomes UP000000834
GO GO:0033650
GO:0042025
GO:0019012
GO:0003723
GO:0003968
GO:0006370
GO:0075526
GO:0039545
GO:0039523
GO:0006351
InterPro IPR001591
Pfam PF00604
ProDom PD001667

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0033650

host cell mitochondrion

PMID:27440905[1]

ECO:0000314

C

Seen in figure 4, PB2 is imported into the mitochondrial matrix of the host. Polymerase basic protein 2 Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

complete
CACAO 12726

involved_in

GO:0039689

negative stranded viral RNA replication

PMID:2214032[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0042025

host cell nucleus

PMID:1985200[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001172

transcription, RNA-templated

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003968

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001591
InterPro:IPR037258

F

Seeded From UniProt

complete

involved_in

GO:0006351

transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037258

P

Seeded From UniProt

complete

involved_in

GO:0039694

viral RNA genome replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001591

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

F

Seeded From UniProt

complete

part_of

GO:0042025

host cell nucleus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

C

Seeded From UniProt

complete

part_of

GO:0019012

virion

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

C

Seeded From UniProt

complete

part_of

GO:0033650

host cell mitochondrion

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

C

Seeded From UniProt

complete

involved_in

GO:0075526

cap snatching

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

P

Seeded From UniProt

complete

involved_in

GO:0006370

7-methylguanosine mRNA capping

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

P

Seeded From UniProt

complete

involved_in

GO:0039523

suppression by virus of host RNA polymerase II activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

P

Seeded From UniProt

complete

enables

GO:0003968

RNA-directed 5'-3' RNA polymerase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

F

Seeded From UniProt

complete

involved_in

GO:0006351

transcription, DNA-templated

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

P

Seeded From UniProt

complete

involved_in

GO:0019083

viral transcription

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

P

Seeded From UniProt

complete

involved_in

GO:0039545

suppression by virus of host MAVS activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000523929

P

Seeded From UniProt

complete

part_of

GO:0042025

host cell nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1048
UniProtKB-SubCell:SL-0414

C

Seeded From UniProt

complete

involved_in

GO:0006370

7-methylguanosine mRNA capping

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0506

P

Seeded From UniProt

complete

part_of

GO:0033650

host cell mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1045
UniProtKB-SubCell:SL-0407

C

Seeded From UniProt

complete

involved_in

GO:0039657

suppression by virus of host gene expression

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1190

P

Seeded From UniProt

complete

involved_in

GO:0030683

evasion or tolerance by virus of host immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0899

P

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

involved_in

GO:0019083

viral transcription

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1195

P

Seeded From UniProt

complete

involved_in

GO:0075526

cap snatching

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1157

P

Seeded From UniProt

complete

involved_in

GO:0039545

suppression by virus of host MAVS activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1097

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0039523

suppression by virus of host RNA polymerase II activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1104

P

Seeded From UniProt

complete

involved_in

GO:0039503

suppression by virus of host innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1090

P

Seeded From UniProt

complete

part_of

GO:0019012

virion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0946
UniProtKB-SubCell:SL-0274

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Long, JC & Fodor, E (2016) The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix. J. Virol. 90 8729-38 PubMed GONUTS page
  2. Huang, TS et al. (1990) Determination of influenza virus proteins required for genome replication. J. Virol. 64 5669-73 PubMed GONUTS page
  3. Mukaigawa, J & Nayak, DP (1991) Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. J. Virol. 65 245-53 PubMed GONUTS page