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HV1N5:POL
Contents
| Species (Taxon ID) | Human immunodeficiency virus type 1 group M subtype B (isolate NY5)(HIV-1). (11698) | |
| Gene Name(s) | gag-pol | |
| Protein Name(s) | Gag-Pol polyprotein
Pr160Gag-Pol Matrix protein p17 MA Capsid protein p24 CA Spacer peptide p2 Nucleocapsid protein p7 NC Transframe peptide TF p6-pol p6* Protease PR Retropepsin Reverse transcriptase/ribonuclease H Exoribonuclease H p66 RT p51 RT p15 Integrase IN | |
| External Links | ||
| UniProt | P12497 | |
| EMBL | M19921 | |
| PDB | 1A43 1A8O 1AFV 1AK4 1AUM 1B92 1B9D 1B9F 1BAJ 1BHL 1BI4 1BIS 1BIU 1BIZ 1BL3 1GWP 1HIW 1HYV 1HYZ 1ITG 1K6Y 1M9D 1QS4 1UPH 1WJB 1WJD 1WKN 1ZA9 2B4J 2GOL 2GON 2H3F 2H3I 2H3Q 2H3V 2H3Z 2HMX 2HVP 2ITG 2JPR 2JYG 2JYL 2LF4 2LYA 2LYB 2M3Z 2M8L 2M8N 2M8P 2ONT 2PWM 2PWO 2PXR 2X2D 2XDE 2XV6 2XXM 3AV9 3AVA 3AVB 3AVC 3AVF 3AVG 3AVH 3AVJ 3AVK 3AVL 3AVM 3AVN 3DIK 3DPH 3DS0 3DS1 3DS2 3DS3 3DS4 3DS5 3DTJ 3GV2 3H47 3H4E 3L3U 3L3V 3LPT 3LPU 3LRY 3MGE 3NF6 3NF7 3NF8 3NF9 3NFA 3P05 3P0A 3S85 3WNE 3WNF 3WNG 3WNH 4AH9 4AHR 4AHS 4AHT 4AHU 4AHV 4COC 4COP 4DGA 4DGE 4DMN 4E1M 4E1N 4E91 4E92 4GVM 4GW6 4ID1 4IPY 4JLH 4JMU 4LQW 4NX4 4O0J 4O55 4O5B 4PHV 5HVP 9HVP | |
| PDBsum | 1A43 1A8O 1AFV 1AK4 1AUM 1B92 1B9D 1B9F 1BAJ 1BHL 1BI4 1BIS 1BIU 1BIZ 1BL3 1GWP 1HIW 1HYV 1HYZ 1ITG 1K6Y 1M9D 1QS4 1UPH 1WJB 1WJD 1WKN 1ZA9 2B4J 2GOL 2GON 2H3F 2H3I 2H3Q 2H3V 2H3Z 2HMX 2HVP 2ITG 2JPR 2JYG 2JYL 2LF4 2LYA 2LYB 2M3Z 2M8L 2M8N 2M8P 2ONT 2PWM 2PWO 2PXR 2X2D 2XDE 2XV6 2XXM 3AV9 3AVA 3AVB 3AVC 3AVF 3AVG 3AVH 3AVJ 3AVK 3AVL 3AVM 3AVN 3DIK 3DPH 3DS0 3DS1 3DS2 3DS3 3DS4 3DS5 3DTJ 3GV2 3H47 3H4E 3L3U 3L3V 3LPT 3LPU 3LRY 3MGE 3NF6 3NF7 3NF8 3NF9 3NFA 3P05 3P0A 3S85 3WNE 3WNF 3WNG 3WNH 4AH9 4AHR 4AHS 4AHT 4AHU 4AHV 4COC 4COP 4DGA 4DGE 4DMN 4E1M 4E1N 4E91 4E92 4GVM 4GW6 4ID1 4IPY 4JLH 4JMU 4LQW 4NX4 4O0J 4O55 4O5B 4PHV 5HVP 9HVP | |
| DisProt | DP00410 | |
| IntAct | P12497 | |
| BindingDB | P12497 | |
| EvolutionaryTrace | P12497 | |
| GO | GO:0030430 GO:0042025 GO:0020002 GO:0016020 GO:0019013 GO:0004190 GO:0003677 GO:0003887 GO:0004533 GO:0042802 GO:0003723 GO:0003964 GO:0004523 GO:0005198 GO:0008270 GO:0015074 GO:0006310 GO:0075713 GO:0039651 GO:0039657 GO:0046718 GO:0075732 GO:0019076 | |
| Gene3D | 1.10.10.200 1.10.1200.30 1.10.150.90 1.10.375.10 2.30.30.10 2.40.70.10 3.30.420.10 4.10.60.10 | |
| InterPro | IPR001969 IPR000721 IPR001037 IPR001584 IPR017856 IPR003308 IPR000071 IPR012344 IPR018061 IPR001995 IPR021109 IPR008916 IPR008919 IPR010999 IPR012337 IPR002156 IPR000477 IPR010659 IPR010661 IPR001878 | |
| Pfam | PF00540 PF00607 PF00552 PF02022 PF00075 PF00665 PF00077 PF00078 PF06815 PF06817 PF00098 | |
| PRINTS | PR00234 | |
| SMART | SM00343 | |
| SUPFAM | SSF46919 SSF47353 SSF47836 SSF47943 SSF50122 SSF50630 SSF53098 SSF57756 | |
| PROSITE | PS50175 PS00141 PS50994 PS51027 PS50879 PS50878 PS50158 PS50876 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004518 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090502 |
RNA phosphodiester bond hydrolysis, endonucleolytic |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004523 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090503 |
RNA phosphodiester bond hydrolysis, exonucleolytic |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004533 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001037 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003964 |
RNA-directed DNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004190 |
aspartic-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004523 |
RNA-DNA hybrid ribonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006278 |
RNA-dependent DNA biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015074 |
DNA integration |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003964 |
RNA-directed DNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003887 |
DNA-directed DNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004533 |
exoribonuclease H activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P12497:PRO_0000042395 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039651 |
induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044826 |
viral genome integration into host DNA |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044174 |
host cell endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075732 |
viral penetration into host nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039657 |
suppression by virus of host gene expression |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075713 |
establishment of integrated proviral latency |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039526 |
modulation by virus of host apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019013 |
viral nucleocapsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015074 |
DNA integration |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003887 |
DNA-directed DNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003964 |
RNA-directed DNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004190 |
aspartic-type endopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072494 |
host multivesicular body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Maignan, S et al. (1998) Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J. Mol. Biol. 282 359-68 PubMed GONUTS page
- ↑ Saad, JS et al. (2006) Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly. Proc. Natl. Acad. Sci. U.S.A. 103 11364-9 PubMed GONUTS page
- ↑ Pornillos, O et al. (2009) X-ray structures of the hexameric building block of the HIV capsid. Cell 137 1282-92 PubMed GONUTS page
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