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HUMAN:ZN423

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ZNF423 (synonyms: KIAA0760, NPHP14, OAZ)
Protein Name(s) Zinc finger protein 423

Olf1/EBF-associated zinc finger protein hOAZ Smad- and Olf-interacting zinc finger protein

External Links
UniProt Q2M1K9
EMBL BC112315
BC112317
AF221712
AB018303
CCDS CCDS32445.1
CCDS61930.1
RefSeq NP_001258549.1
NP_055884.2
XP_005255913.1
UniGene Hs.530930
Hs.744482
PDB 2MDG
PDBsum 2MDG
ProteinModelPortal Q2M1K9
SMR Q2M1K9
BioGrid 116718
IntAct Q2M1K9
MINT MINT-2819859
STRING 9606.ENSP00000262383
PhosphoSite Q2M1K9
DMDM 121941357
PaxDb Q2M1K9
PRIDE Q2M1K9
DNASU 23090
Ensembl ENST00000262383
ENST00000561648
ENST00000562520
ENST00000562871
ENST00000563137
GeneID 23090
KEGG hsa:23090
UCSC uc010vgn.3
CTD 23090
GeneCards GC16M049524
HGNC HGNC:16762
HPA HPA015258
MIM 604557
614844
neXtProt NX_Q2M1K9
Orphanet 2318
PharmGKB PA134903681
eggNOG COG5048
GeneTree ENSGT00800000124054
HOGENOM HOG000155793
HOVERGEN HBG052773
InParanoid Q2M1K9
OMA FIEHCQM
OrthoDB EOG7NGQB0
PhylomeDB Q2M1K9
TreeFam TF331504
ChiTaRS ZNF423
GeneWiki ZNF423
GenomeRNAi 23090
NextBio 44239
PRO PR:Q2M1K9
Proteomes UP000005640
Bgee Q2M1K9
CleanEx HS_ZNF423
ExpressionAtlas Q2M1K9
Genevisible Q2M1K9
GO GO:0005634
GO:0003677
GO:0046872
GO:0030154
GO:0045892
GO:0007399
GO:0007219
GO:0030513
GO:0045893
GO:0006351
Gene3D 3.30.160.60
InterPro IPR007087
IPR015880
IPR013087
Pfam PF00096
SMART SM00355
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

PMID:27238639[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q80TS5

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q8VIG1

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10660046[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:10660046[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030513

positive regulation of BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q80TS5

P

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q80TS5

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10660046[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037618
MGI:MGI:1353563
PANTHER:PTN001227002
ZFIN:ZDB-GENE-100318-5

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000286
FB:FBgn0000289
FB:FBgn0003448
MGI:MGI:1096393
MGI:MGI:1353563
MGI:MGI:2139287
MGI:MGI:2176606
MGI:MGI:98330
PANTHER:PTN001227002
RGD:1310136
SGD:S000004972
UniProtKB:O43623
UniProtKB:Q2M1K9
UniProtKB:Q4WJ81
UniProtKB:Q8NAP3
UniProtKB:Q9P1Z0
UniProtKB:Q9Y2X9
WB:WBGene00001324

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037618
MGI:MGI:1353563
PANTHER:PTN001227002
RGD:1310136
UniProtKB:Q9Y2X9

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003448
FB:FBgn0037617
FB:FBgn0039860
PANTHER:PTN001227002

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80TS5
ensembl:ENSMUSP00000105282

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80TS5
ensembl:ENSMUSP00000105282

P

Seeded From UniProt

complete

involved_in

GO:0030513

positive regulation of BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80TS5
ensembl:ENSMUSP00000105282

P

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80TS5
ensembl:ENSMUSP00000105282

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80TS5
ensembl:ENSMUSP00000105282

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Shao, M et al. (2016) Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. Cell Metab. 23 1167-1184 PubMed GONUTS page
  2. 2.0 2.1 2.2 Hata, A et al. (2000) OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100 229-40 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page