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HUMAN:ZN363
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RCHY1 (synonyms: ARNIP, CHIMP, PIRH2, RNF199, ZNF363) | |
| Protein Name(s) | RING finger and CHY zinc finger domain-containing protein 1
Androgen receptor N-terminal-interacting protein CH-rich-interacting match with PLAG1 E3 ubiquitin-protein ligase Pirh2 RING finger protein 199 Zinc finger protein 363 p53-induced RING-H2 protein hPirh2 | |
| External Links | ||
| UniProt | Q96PM5 | |
| EMBL | GQ250944 GQ250945 GQ250946 AF247041 AF255666 AF305424 AB209072 AY888047 GU937000 AK091501 AC096759 CH471057 BC047393 | |
| CCDS | CCDS34012.1 CCDS3567.1 CCDS63990.1 CCDS63991.1 CCDS63992.1 | |
| RefSeq | NP_001009922.1 NP_001265465.1 NP_001265466.1 NP_001265467.1 NP_056251.2 | |
| UniGene | Hs.48297 | |
| PDB | 2JRJ 2K2C 2K2D | |
| PDBsum | 2JRJ 2K2C 2K2D | |
| ProteinModelPortal | Q96PM5 | |
| SMR | Q96PM5 | |
| BioGrid | 117406 | |
| DIP | DIP-43981N | |
| IntAct | Q96PM5 | |
| MINT | MINT-3057007 | |
| STRING | 9606.ENSP00000321239 | |
| PhosphoSite | Q96PM5 | |
| DMDM | 32700008 | |
| REPRODUCTION-2DPAGE | Q96PM5 | |
| MaxQB | Q96PM5 | |
| PaxDb | Q96PM5 | |
| PRIDE | Q96PM5 | |
| DNASU | 25898 | |
| Ensembl | ENST00000324439 ENST00000380840 ENST00000505105 ENST00000507014 ENST00000512706 ENST00000513257 | |
| GeneID | 25898 | |
| KEGG | hsa:25898 | |
| UCSC | uc003hik.3 uc003hil.3 uc010iip.3 | |
| CTD | 25898 | |
| GeneCards | GC04M076405 | |
| HGNC | HGNC:17479 | |
| HPA | HPA030339 | |
| MIM | 607680 | |
| neXtProt | NX_Q96PM5 | |
| PharmGKB | PA38240 | |
| eggNOG | NOG325406 | |
| GeneTree | ENSGT00390000008853 | |
| HOGENOM | HOG000231827 | |
| HOVERGEN | HBG062959 | |
| InParanoid | Q96PM5 | |
| KO | K10144 | |
| OMA | CGSYNTA | |
| OrthoDB | EOG7XH6QG | |
| PhylomeDB | Q96PM5 | |
| TreeFam | TF323762 | |
| BRENDA | 6.3.2.19 | |
| Reactome | REACT_75842 | |
| UniPathway | UPA00143 | |
| ChiTaRS | RCHY1 | |
| EvolutionaryTrace | Q96PM5 | |
| GeneWiki | RCHY1 | |
| GenomeRNAi | 25898 | |
| NextBio | 35483477 | |
| PRO | PR:Q96PM5 | |
| Proteomes | UP000005640 | |
| Bgee | Q96PM5 | |
| CleanEx | HS_RCHY1 | |
| ExpressionAtlas | Q96PM5 | |
| Genevestigator | Q96PM5 | |
| GO | GO:0005737 GO:0016607 GO:0005634 GO:0000151 GO:0016874 GO:0002039 GO:0042803 GO:0004842 GO:0008270 GO:0032436 GO:0031398 GO:0051865 GO:0016567 GO:0042787 | |
| Gene3D | 2.20.28.10 3.30.40.10 | |
| InterPro | IPR004039 IPR008913 IPR017921 IPR001841 IPR013083 | |
| Pfam | PF05495 PF13639 | |
| SMART | SM00184 | |
| PROSITE | PS51266 PS51270 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000151 |
ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5XIE4 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051865 |
protein autoubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070987 |
error-free translesion synthesis |
Reactome:R-HSA-110320 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5655170 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
Reactome:R-HSA-5655170 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1A shows the staining of the nucleus through co-localization via DAPI staining. RING finger and CHY zinc finger domain-containing protein 1/RCHY1-Homo sapiens |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhang, L et al. (2005) A new human gene hNTKL-BP1 interacts with hPirh2. Biochem. Biophys. Res. Commun. 330 293-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Corcoran, CA et al. (2009) Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J. Biol. Chem. 284 21955-70 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Sheng, Y et al. (2008) Molecular basis of Pirh2-mediated p53 ubiquitylation. Nat. Struct. Mol. Biol. 15 1334-42 PubMed GONUTS page
- ↑ Dong, L et al. (2015) Human Pirh2 is a novel inhibitor of prototype foamy virus replication. Viruses 7 1668-84 PubMed GONUTS page
p
- GO:0002039 ! p53 binding
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0031398 ! positive regulation of protein ubiquitination
- Primates
- GO:0051865 ! protein autoubiquitination
- GO:0042803 ! protein homodimerization activity
- GO:0016567 ! protein ubiquitination
u
