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HUMAN:ZFY27

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ZFYVE27
Protein Name(s) Protrudin

Zinc finger FYVE domain-containing protein 27

External Links
UniProt Q5T4F4
EMBL AK057481
AK097945
AK074876
AK296295
AK296588
AK299735
AL358938
AL358938
AL358938
BC030621
AL834235
CCDS CCDS31263.1
CCDS31264.1
CCDS53562.1
CCDS53563.1
CCDS53564.1
CCDS53565.1
RefSeq NP_001002261.1
NP_001002262.1
NP_001167590.1
NP_001167591.1
NP_001167592.1
NP_001167593.1
NP_653189.3
XP_005269559.1
XP_005269560.1
XP_005269561.1
XP_005269563.1
UniGene Hs.744075
PDB 1X4U
PDBsum 1X4U
ProteinModelPortal Q5T4F4
SMR Q5T4F4
BioGrid 125623
IntAct Q5T4F4
PhosphoSite Q5T4F4
DMDM 74744927
MaxQB Q5T4F4
PaxDb Q5T4F4
PRIDE Q5T4F4
Ensembl ENST00000337540
ENST00000357540
ENST00000359980
ENST00000370610
ENST00000370613
ENST00000393677
GeneID 118813
KEGG hsa:118813
UCSC uc001kol.2
uc001kom.2
uc001koq.3
uc021pwq.1
CTD 118813
GeneCards GC10P099486
HGNC HGNC:26559
HPA HPA037523
MIM 610243
610244
neXtProt NX_Q5T4F4
PharmGKB PA134863310
eggNOG NOG28771
GeneTree ENSGT00390000013298
HOVERGEN HBG054907
InParanoid Q5T4F4
OMA SYKRLEI
OrthoDB EOG7VTDNG
PhylomeDB Q5T4F4
TreeFam TF331044
ChiTaRS ZFYVE27
EvolutionaryTrace Q5T4F4
GenomeRNAi 118813
NextBio 35535086
PRO PR:Q5T4F4
Proteomes UP000005640
Bgee Q5T4F4
ExpressionAtlas Q5T4F4
Genevestigator Q5T4F4
GO GO:0030424
GO:0030425
GO:0005783
GO:0005789
GO:0032584
GO:0016021
GO:0055038
GO:0046872
GO:0031175
GO:0048011
GO:0072659
Gene3D 3.30.40.10
InterPro IPR000306
IPR017455
IPR011011
IPR013083
Pfam PF01363
SMART SM00064
SUPFAM SSF57903
PROSITE PS50178

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0071782

endoplasmic reticulum tubular network

PMID:23969831[1]

ECO:0000314

C

Figure 1

complete
CACAO 8513

involved_in

GO:0071787

endoplasmic reticulum tubular network formation

PMID:24668814[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071782

endoplasmic reticulum tubular network

PMID:24668814[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071787

endoplasmic reticulum tubular network formation

PMID:23969831[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043621

protein self-association

PMID:23969831[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030176

integral component of endoplasmic reticulum membrane

PMID:23969831[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045773

positive regulation of axon extension

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TXX3

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

PMID:21976701[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071782

endoplasmic reticulum tubular network

PMID:23969831[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072659

protein localization to plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6P7B7

P

Seeded From UniProt

complete

part_of

GO:0055038

recycling endosome membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6P7B7

C

Seeded From UniProt

complete

involved_in

GO:0048011

neurotrophin TRK receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6P7B7

P

Seeded From UniProt

complete

part_of

GO:0032584

growth cone membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TXX3

C

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

PMID:17082457[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TXX3

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TXX3

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:19289470[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072659

protein localization to plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000122700
RGD:735177

P

Seeded From UniProt

complete

involved_in

GO:0071787

endoplasmic reticulum tubular network formation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000122700
UniProtKB:Q5T4F4

P

Seeded From UniProt

complete

part_of

GO:0071782

endoplasmic reticulum tubular network

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919602
PANTHER:PTN000122700
UniProtKB:Q5T4F4

C

Seeded From UniProt

complete

involved_in

GO:0048011

neurotrophin TRK receptor signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002684487
RGD:735177

P

Seeded From UniProt

complete

involved_in

GO:0045773

positive regulation of axon extension

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919602
PANTHER:PTN002684487

P

Seeded From UniProt

complete

enables

GO:0043621

protein self-association

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000122700
UniProtKB:Q5T4F4

F

Seeded From UniProt

complete

part_of

GO:0032584

growth cone membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919602
PANTHER:PTN002684487
RGD:735177

C

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002684487
RGD:735177
UniProtKB:Q5T4F4

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919602
PANTHER:PTN000122700
UniProtKB:Q5T4F4

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071782

endoplasmic reticulum tubular network

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

C

Seeded From UniProt

complete

involved_in

GO:0045773

positive regulation of axon extension

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

P

Seeded From UniProt

complete

part_of

GO:0032584

growth cone membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

C

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TXX3
ensembl:ENSMUSP00000130684

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000306

F

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0032584

growth cone membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0289

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

part_of

GO:0055038

recycling endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0231

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Chang, J et al. (2013) Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Proc. Natl. Acad. Sci. U.S.A. 110 14954-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Hashimoto, Y et al. (2014) Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. J. Biol. Chem. 289 12946-61 PubMed GONUTS page
  3. ↑ Matsuzaki, F et al. (2011) Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Mol. Biol. Cell 22 4602-20 PubMed GONUTS page
  4. ↑ Shirane, M & Nakayama, KI (2006) Protrudin induces neurite formation by directional membrane trafficking. Science 314 818-21 PubMed GONUTS page
  5. ↑ Saita, S et al. (2009) Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. J. Biol. Chem. 284 13766-77 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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