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PMID:17082457

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Citation

Shirane, M and Nakayama, KI (2006) Protrudin induces neurite formation by directional membrane trafficking. Science 314:818-21

Abstract

Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a mammalian protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphorylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted protrudin association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus, protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation.

Links

PubMed Online version:10.1126/science.1134027

Keywords

Amino Acid Sequence; Animals; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Adhesion Molecules/metabolism; Cell Line; Cell Membrane/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Guanosine Diphosphate/metabolism; HeLa Cells; Humans; MAP Kinase Kinase 1/metabolism; Membrane Proteins; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nerve Growth Factor/pharmacology; Nerve Growth Factor/physiology; Neurites/physiology; PC12 Cells; Phosphorylation; RNA Interference; Rats; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Vesicular Transport Proteins; rab GTP-Binding Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:RB11A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q5T4F4

F

Seeded From UniProt

complete

HUMAN:RB11A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q7L804

F

Seeded From UniProt

complete

HUMAN:FKBP8

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q5T4F4

F

Seeded From UniProt

complete

MOUSE:ZFY27

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ZFY27

located_in

GO:0030424: axon

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ZFY27

located_in

GO:0032584: growth cone membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ZFY27

located_in

GO:0030425: dendrite

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ZFY27

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P62491

F

Seeded From UniProt

complete

HUMAN:ZFY27

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q14318

F

Seeded From UniProt

complete

RAT:ZFY27

located_in

GO:0055038: recycling endosome membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:ZFY27

located_in

GO:0032584: growth cone membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

RAT:ZFY27

involved_in

GO:0031175: neuron projection development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ZFY27

involved_in

GO:0048011: neurotrophin TRK receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ZFY27

involved_in

GO:0072659: protein localization to plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RFIP2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P62491

F

Seeded From UniProt

complete

HUMAN:ZFY27

involved_in

GO:0031175: neuron projection development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RB11A

involved_in

GO:0072659: protein localization to plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RB11A

involved_in

GO:0031175: neuron projection development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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