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HUMAN:XRCC4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) XRCC4
Protein Name(s) DNA repair protein XRCC4

X-ray repair cross-complementing protein 4

External Links
UniProt Q13426
EMBL U40622
AF055285
AF055279
AF055280
AF055281
AF055282
AF055283
AF055284
AF055285
AF055279
AF055280
AF055281
AF055282
AF055283
AF055284
AB017445
BT007216
AK290739
AY940097
CH471084
BC005259
BC016314
CCDS CCDS4058.1
CCDS4059.1
RefSeq NP_003392.1
NP_071801.1
NP_072044.1
XP_005248652.1
UniGene Hs.567359
PDB 1FU1
1IK9
3II6
3MUD
3Q4F
3RWR
3SR2
3W03
PDBsum 1FU1
1IK9
3II6
3MUD
3Q4F
3RWR
3SR2
3W03
DisProt DP00152
ProteinModelPortal Q13426
SMR Q13426
BioGrid 113352
DIP DIP-37957N
IntAct Q13426
MINT MINT-1205583
STRING 9606.ENSP00000342011
PhosphoSite Q13426
DMDM 44888352
MaxQB Q13426
PaxDb Q13426
PRIDE Q13426
DNASU 7518
Ensembl ENST00000282268
ENST00000338635
ENST00000396027
ENST00000511817
GeneID 7518
KEGG hsa:7518
UCSC uc003kia.1
uc003kib.3
uc003kic.3
CTD 7518
GeneCards GC05P082409
HGNC HGNC:12831
HPA HPA006801
HPA051538
MIM 194363
neXtProt NX_Q13426
PharmGKB PA37423
eggNOG NOG69713
GeneTree ENSGT00390000017079
HOGENOM HOG000013067
HOVERGEN HBG059517
InParanoid Q13426
KO K10886
OMA NFSKESC
OrthoDB EOG7288TZ
PhylomeDB Q13426
TreeFam TF101204
Reactome REACT_1022
REACT_9058
ChiTaRS XRCC4
EvolutionaryTrace Q13426
GeneWiki XRCC4
GenomeRNAi 7518
NextBio 29423
PMAP-CutDB Q13426
PRO PR:Q13426
Proteomes UP000005640
Bgee Q13426
CleanEx HS_XRCC4
ExpressionAtlas Q13426
Genevestigator Q13426
GO GO:0030054
GO:0005813
GO:0005829
GO:0032807
GO:0005958
GO:0070419
GO:0005654
GO:0005634
GO:0008022
GO:0071285
GO:0007417
GO:0051103
GO:0006281
GO:0006302
GO:0006303
GO:0075713
GO:0033152
GO:0001701
GO:0045190
GO:0043524
GO:0048146
GO:0051351
GO:0050769
GO:0002328
GO:0010332
GO:0010165
GO:0033077
GO:0016032
Gene3D 1.20.5.370
2.170.210.10
InterPro IPR010585
IPR014751
IPR009089
Pfam PF06632
SUPFAM SSF50809

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070419

nonhomologous end joining complex

PMID:25941166[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070419

nonhomologous end joining complex

PMID:20383123[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051351

positive regulation of ligase activity

PMID:9242410[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051103

DNA ligation involved in DNA repair

PMID:12517771[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032807

DNA ligase IV complex

PMID:9242410[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

NOT|enables

GO:0016874

ligase activity

PMID:9242410[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010165

response to X-ray

PMID:9242410[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

PMID:9259561[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P49917

F

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:9809069[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:P49917

P

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:12517771[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:16439205[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

PMID:9242410[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:9259561[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12589063[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9259561[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16439205[7]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

NOT|enables

GO:0003677

DNA binding

PMID:9259561[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|part_of

GO:0000793

condensed chromosome

PMID:12589063[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1333799
PANTHER:PTN002004633
UniProtKB:Q13426

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002004633
UniProtKB:Q13426

C

Seeded From UniProt

complete

part_of

GO:0005958

DNA-dependent protein kinase-DNA ligase 4 complex

PMID:15194694[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13426

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21768349[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13426

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16169070[13]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13426

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071285

cellular response to lithium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XI44
ensembl:ENSRNOP00000048754

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009089
InterPro:IPR010585

C

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009089
InterPro:IPR010585

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009089
InterPro:IPR010585

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21070942[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13426-2

F

Seeded From UniProt

complete

involved_in

GO:0075713

establishment of integrated proviral latency

Reactome:R-HSA-162592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

Reactome:R-HSA-5693571

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5693604
Reactome:R-HSA-5693574
Reactome:R-HSA-5687360
Reactome:R-HSA-4568848
Reactome:R-HSA-175258
Reactome:R-HSA-175177

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Craxton, A et al. (2015) XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair. Cell Death Differ. 22 890-7 PubMed GONUTS page
  2. ↑ Roberts, SA et al. (2010) Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature 464 1214-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Grawunder, U et al. (1997) Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388 492-5 PubMed GONUTS page
  4. ↑ 4.0 4.1 Lee, JW et al. (2003) Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Res. 63 22-4 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Critchlow, SE et al. (1997) Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7 588-98 PubMed GONUTS page
  6. ↑ Grawunder, U et al. (1998) DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2 477-84 PubMed GONUTS page
  7. ↑ 7.0 7.1 Ahnesorg, P et al. (2006) XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124 301-13 PubMed GONUTS page
  8. ↑ 8.0 8.1 Przewloka, MR et al. (2003) In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex. Mol. Biol. Cell 14 685-97 PubMed GONUTS page
  9. ↑ 9.0 9.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. ↑ Wang, YG et al. (2004) Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J. Biol. Chem. 279 37282-90 PubMed GONUTS page
  11. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  12. ↑ Ropars, V et al. (2011) Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining. Proc. Natl. Acad. Sci. U.S.A. 108 12663-8 PubMed GONUTS page
  13. ↑ Stelzl, U et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 957-68 PubMed GONUTS page
  14. ↑ Hammel, M et al. (2010) XLF regulates filament architecture of the XRCC4·ligase IV complex. Structure 18 1431-42 PubMed GONUTS page
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