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HUMAN:WDR62
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | WDR62 (synonyms: C19orf14) | |
| Protein Name(s) | WD repeat-containing protein 62 | |
| External Links | ||
| UniProt | O43379 | |
| EMBL | AK090617 BX647726 AL133651 AD000813 AC004144 BC017261 BC058939 | |
| CCDS | CCDS33001.1 CCDS46059.1 | |
| PIR | T01437 | |
| RefSeq | NP_001077430.1 NP_775907.4 | |
| UniGene | Hs.116244 | |
| ProteinModelPortal | O43379 | |
| SMR | O43379 | |
| BioGrid | 129863 | |
| IntAct | O43379 | |
| MINT | MINT-1376343 | |
| STRING | 9606.ENSP00000384792 | |
| PhosphoSite | O43379 | |
| MaxQB | O43379 | |
| PaxDb | O43379 | |
| PRIDE | O43379 | |
| DNASU | 284403 | |
| Ensembl | ENST00000270301 ENST00000401500 ENST00000587391 | |
| GeneID | 284403 | |
| KEGG | hsa:284403 | |
| UCSC | uc002odb.2 uc002odc.2 uc002odd.2 | |
| CTD | 284403 | |
| GeneCards | GC19P036545 | |
| GeneReviews | WDR62 | |
| HGNC | HGNC:24502 | |
| HPA | CAB046468 HPA043255 HPA043639 | |
| MIM | 604317 613583 | |
| neXtProt | NX_O43379 | |
| Orphanet | 2512 | |
| PharmGKB | PA134963627 | |
| eggNOG | COG2319 | |
| GeneTree | ENSGT00770000120572 | |
| HOGENOM | HOG000010231 | |
| HOVERGEN | HBG108669 | |
| InParanoid | O43379 | |
| OMA | LASTFLW | |
| OrthoDB | EOG74N5FW | |
| PhylomeDB | O43379 | |
| TreeFam | TF323254 | |
| SignaLink | O43379 | |
| ChiTaRS | WDR62 | |
| GeneWiki | WDR62 | |
| GenomeRNAi | 284403 | |
| NextBio | 94836 | |
| PRO | PR:O43379 | |
| Proteomes | UP000005640 | |
| Bgee | O43379 | |
| CleanEx | HS_WDR62 | |
| ExpressionAtlas | O43379 | |
| Genevestigator | O43379 | |
| GO | GO:0005737 GO:0005634 GO:0000922 GO:0021987 GO:0022008 | |
| Gene3D | 2.130.10.10 | |
| InterPro | IPR011047 IPR015943 IPR001680 IPR017986 | |
| Pfam | PF00400 | |
| SMART | SM00320 | |
| SUPFAM | SSF50978 SSF50998 | |
| PROSITE | PS50082 PS50294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
F |
Figure 1B. |
complete | |||||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007099 |
centriole replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021987 |
cerebral cortex development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000922 |
spindle pole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000922 |
spindle pole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001871421 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007052 |
mitotic spindle organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001871421 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001871421 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000922 |
spindle pole |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001871421 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007052 |
mitotic spindle organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005814 |
centriole |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000922 |
spindle pole |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Cohen-Katsenelson, K et al. (2013) Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins. J. Biol. Chem. 288 7294-304 PubMed GONUTS page
- ↑ 2.0 2.1 Kodani, A et al. (2015) Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife 4 PubMed GONUTS page
- ↑ 3.0 3.1 Yu, TW et al. (2010) Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture. Nat. Genet. 42 1015-20 PubMed GONUTS page
- ↑ 4.0 4.1 Bilgüvar, K et al. (2010) Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature 467 207-10 PubMed GONUTS page
- ↑ Nicholas, AK et al. (2010) WDR62 is associated with the spindle pole and is mutated in human microcephaly. Nat. Genet. 42 1010-4 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Xu, D et al. (2014) Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Rep 6 104-16 PubMed GONUTS page
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