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HUMAN:WDR5
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | WDR5 (synonyms: BIG3) | |
| Protein Name(s) | WD repeat-containing protein 5
BMP2-induced 3-kb gene protein | |
| External Links | ||
| UniProt | P61964 | |
| EMBL | AJ011376 AK000552 BC001635 | |
| CCDS | CCDS6981.1 | |
| RefSeq | NP_060058.1 NP_438172.1 XP_005272220.1 | |
| UniGene | Hs.397638 | |
| PDB | 2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4CY1 4CY2 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4GM9 4GMB 4IA9 4O45 4QL1 4Y7R 5EAL 5EAM 5EAP 5EAR | |
| PDBsum | 2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4CY1 4CY2 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4GM9 4GMB 4IA9 4O45 4QL1 4Y7R 5EAL 5EAM 5EAP 5EAR | |
| ProteinModelPortal | P61964 | |
| SMR | P61964 | |
| BioGrid | 116272 | |
| DIP | DIP-29223N | |
| IntAct | P61964 | |
| MINT | MINT-1464227 | |
| STRING | 9606.ENSP00000351446 | |
| BindingDB | P61964 | |
| ChEMBL | CHEMBL1075317 | |
| GuidetoPHARMACOLOGY | 2831 | |
| iPTMnet | P61964 | |
| PhosphoSite | P61964 | |
| BioMuta | WDR5 | |
| DMDM | 48429182 | |
| MaxQB | P61964 | |
| PaxDb | P61964 | |
| PRIDE | P61964 | |
| DNASU | 11091 | |
| Ensembl | ENST00000358625 | |
| GeneID | 11091 | |
| KEGG | hsa:11091 | |
| UCSC | uc004cey.3 | |
| CTD | 11091 | |
| GeneCards | WDR5 | |
| HGNC | HGNC:12757 | |
| MIM | 609012 | |
| neXtProt | NX_P61964 | |
| PharmGKB | PA37361 | |
| eggNOG | KOG0266 ENOG410XP3K | |
| GeneTree | ENSGT00810000125363 | |
| HOGENOM | HOG000091642 | |
| HOVERGEN | HBG055117 | |
| InParanoid | P61964 | |
| KO | K14963 | |
| OMA | CIKTLPA | |
| OrthoDB | EOG7MH0ZD | |
| PhylomeDB | P61964 | |
| TreeFam | TF314125 | |
| Reactome | R-HSA-3214841 R-HSA-3214847 R-HSA-3214858 | |
| SignaLink | P61964 | |
| EvolutionaryTrace | P61964 | |
| GeneWiki | WDR5 | |
| GenomeRNAi | 11091 | |
| NextBio | 42156 | |
| PRO | PR:P61964 | |
| Proteomes | UP000005640 | |
| Bgee | P61964 | |
| CleanEx | HS_WDR5 | |
| ExpressionAtlas | P61964 | |
| Genevisible | P61964 | |
| GO | GO:0005671 GO:0000123 GO:0035097 GO:0071339 GO:0005654 GO:0005634 GO:0048188 GO:0006325 GO:0043966 GO:0051568 GO:0043984 GO:0043981 GO:0043982 GO:0031175 GO:0035948 GO:0001501 GO:0006351 | |
| Gene3D | 2.130.10.10 | |
| InterPro | IPR020472 IPR015943 IPR001680 IPR019775 IPR017986 | |
| Pfam | PF00400 | |
| PRINTS | PR00320 | |
| SMART | SM00320 | |
| SUPFAM | SSF50978 | |
| PROSITE | PS00678 PS50082 PS50294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0044666 |
MLL3/4 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035064 |
methylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043966 |
histone H3 acetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005671 |
Ada2/Gcn5/Ada3 transcription activator complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0071339 |
MLL1 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048188 |
Set1C/COMPASS complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048188 |
Set1C/COMPASS complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0046972 |
histone acetyltransferase activity (H4-K16 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0043996 |
histone acetyltransferase activity (H4-K8 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0043995 |
histone acetyltransferase activity (H4-K5 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043984 |
histone H4-K16 acetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043982 |
histone H4-K8 acetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043981 |
histone H4-K5 acetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0042800 |
histone methyltransferase activity (H3-K4 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000123 |
histone acetyltransferase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040066 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048188 |
Set1C/COMPASS complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040066 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042393 |
histone binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001483578 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040066 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61965 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035948 |
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61965 |
P |
Seeded From UniProt |
complete | ||
| GO:0051572 |
negative regulation of histone H3-K4 methylation |
ECO:0000314 |
P |
"The MLL3 core complex in the presence of WDR5 shows only H3K4 monomethylation activity that is stimulated in comparison with the isolated MLL3 SET domain but is ∼64-fold slower than the monomethylation rate catalyzed by the MLL1 core complex" Fig. 1D, 1F, 6A and Table 1 |
complete | |||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61965 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001501 |
skeletal system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61965 |
P |
Seeded From UniProt |
complete | ||
| GO:0051571 |
positive regulation of histone H3-K4 methylation |
ECO:0000314 |
P |
WDR5 stimulates H3K4 monomethylation and dimethylation in complex MLL1 Figure 1C When the assays were conducted with complexes that omitted the WDR5 subunit, the MLL1 core complex displayed a 64-fold decrease in the rate of H3K4 mono-methylation compared with the holo-MLL1 core complex and nearly abolished detectable levels of H3K4 di-methylation (Fig. 1E and Table 1) |
complete | |||||
|
involved_in |
GO:0031175 |
neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q498M4 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q498M4 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045652 |
regulation of megakaryocyte differentiation |
Reactome:R-HSA-8936459 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8956045 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
- ↑ Han, Z et al. (2006) Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol. Cell 22 137-44 PubMed GONUTS page
- ↑ 3.0 3.1 Wang, YL et al. (2008) Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J. Biol. Chem. 283 33808-15 PubMed GONUTS page
- ↑ Dou, Y et al. (2005) Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121 873-85 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lee, JH et al. (2007) Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. J. Biol. Chem. 282 13419-28 PubMed GONUTS page
- ↑ 6.0 6.1 Patel, A et al. (2009) On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J. Biol. Chem. 284 24242-56 PubMed GONUTS page
- ↑ Wu, M et al. (2008) Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol. Cell. Biol. 28 7337-44 PubMed GONUTS page
- ↑ Lee, JH & Skalnik, DG (2008) Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Mol. Cell. Biol. 28 609-18 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 Cai, Y et al. (2010) Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J. Biol. Chem. 285 4268-72 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 11.0 11.1 Shinsky, SA & Cosgrove, MS (2015) Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex. J. Biol. Chem. 290 25819-33 PubMed GONUTS page
h
- Haplorrhini
- GO:0000123 ! histone acetyltransferase complex
- GO:0042393 ! histone binding
- GO:0042800 ! histone H3K4 methyltransferase activity
- GO:0046972 ! histone H4K16 acetyltransferase activity
- GO:0043995 ! histone H4K5 acetyltransferase activity
- GO:0043996 ! histone H4K8 acetyltransferase activity
- GO:0035097 ! histone methyltransferase complex
- Hominidae
- Homo
- Homo sapiens
m
o
- GO:0005671 ! obsolete Ada2/Gcn5/Ada3 transcription activator complex
- GO:0043981 ! obsolete histone H4-K5 acetylation
- GO:0051568 ! obsolete histone H3-K4 methylation
- GO:0043966 ! obsolete histone H3 acetylation
- GO:0043982 ! obsolete histone H4-K8 acetylation
- GO:0043984 ! obsolete histone H4-K16 acetylation
- GO:0051572 ! obsolete negative regulation of histone H3-K4 methylation
- GO:0051571 ! obsolete positive regulation of histone H3-K4 methylation
- GO:0035948 ! obsolete positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
