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HUMAN:VPRBP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) VPRBP (synonyms: DCAF1, KIAA0800, RIP)
Protein Name(s) Protein VPRBP

DDB1- and CUL4-associated factor 1 HIV-1 Vpr-binding protein VprBP Serine/threonine-protein kinase VPRBP Vpr-interacting protein

External Links
UniProt Q9Y4B6
EMBL AB018343
AC092037
BC022792
BC110371
AL080145
AF061935
CCDS CCDS74943.1
CCDS74944.1
PIR T12529
RefSeq NP_001165375.1
NP_055518.1
XP_005276808.1
XP_005276809.1
XP_005276810.1
XP_005276811.1
XP_005276812.1
XP_006713489.1
XP_006713490.1
UniGene Hs.716623
PDB 3WA0
4CC9
4P7I
4PXW
PDBsum 3WA0
4CC9
4P7I
4PXW
ProteinModelPortal Q9Y4B6
SMR Q9Y4B6
BioGrid 115079
DIP DIP-47048N
IntAct Q9Y4B6
MINT MINT-4947153
STRING 9606.ENSP00000273612
PhosphoSite Q9Y4B6
DMDM 147742890
MaxQB Q9Y4B6
PaxDb Q9Y4B6
PRIDE Q9Y4B6
Ensembl ENST00000335891
ENST00000423656
ENST00000504652
GeneID 9730
KEGG hsa:9730
UCSC uc003dbe.2
uc021wys.1
CTD 9730
GeneCards GC03M051433
HGNC HGNC:30911
HPA HPA036142
neXtProt NX_Q9Y4B6
PharmGKB PA142670621
eggNOG NOG237621
GeneTree ENSGT00390000005874
HOGENOM HOG000007026
HOVERGEN HBG108659
InParanoid Q9Y4B6
KO K11789
OMA XAFSARE
PhylomeDB Q9Y4B6
Reactome REACT_75842
UniPathway UPA00143
ChiTaRS VPRBP
GeneWiki VPRBP
GenomeRNAi 9730
NextBio 36604
PRO PR:Q9Y4B6
Proteomes UP000005640
Bgee Q9Y4B6
CleanEx HS_VPRBP
ExpressionAtlas Q9Y4B6
Genevestigator Q9Y4B6
GO GO:0005737
GO:0005634
GO:0005524
GO:1990244
GO:0030183
GO:0035212
GO:1990245
GO:0000122
GO:0016567
GO:0006351
GO:0033151
GO:0016032
Gene3D 1.25.10.10
2.130.10.10
InterPro IPR011989
IPR016024
IPR006594
IPR015943
IPR017986
SMART SM00667
SUPFAM SSF48371
SSF50978
PROSITE PS50896

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0080008

Cul4-RING E3 ubiquitin ligase complex

PMID:16949367[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030331

estrogen receptor binding

PMID:28068668[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P03372

F

Seeded From UniProt

complete

involved_in

GO:1990245

histone H2A-T120 phosphorylation

PMID:24140421[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990244

histone kinase activity (H2A-T120 specific)

PMID:24140421[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035212

cell competition in a multicellular organism

PMID:20644714[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033151

V(D)J recombination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q80TR8

P

Seeded From UniProt

complete

involved_in

GO:0030183

B cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q80TR8

P

Seeded From UniProt

complete

colocalizes_with

GO:0008180

COP9 signalosome

PMID:18850735[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20178741[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:24140421[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1990245

histone H2A-T120 phosphorylation

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000319712
UniProtKB:Q9Y4B6

P

Seeded From UniProt

complete

enables

GO:1990244

histone kinase activity (H2A-T120 specific)

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000319712
UniProtKB:Q9Y4B6

F

Seeded From UniProt

complete

part_of

GO:0080008

Cul4-RING E3 ubiquitin ligase complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000319709
TAIR:locus:2126296
UniProtKB:Q9Y4B6

C

Seeded From UniProt

complete

enables

GO:0030331

estrogen receptor binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000319712
UniProtKB:Q9Y4B6

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000319709
TAIR:locus:2126296
UniProtKB:Q9Y4B6

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001650

fibrillar center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0033151

V(D)J recombination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80TR8
ensembl:ENSMUSP00000123865

P

Seeded From UniProt

complete

involved_in

GO:0030183

B cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80TR8
ensembl:ENSMUSP00000123865

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033270

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Jin, J et al. (2006) A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell 23 709-21 PubMed GONUTS page
  2. ↑ Britschgi, A et al. (2017) The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature 541 541-545 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Kim, K et al. (2013) VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. Mol. Cell 52 459-67 PubMed GONUTS page
  4. ↑ Tamori, Y et al. (2010) Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 8 e1000422 PubMed GONUTS page
  5. ↑ Fang, L et al. (2008) Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J. Proteome Res. 7 4914-25 PubMed GONUTS page
  6. ↑ Li, W et al. (2010) Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 140 477-90 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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