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HUMAN:UROM

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UMOD
Protein Name(s) Uromodulin

Tamm-Horsfall urinary glycoprotein THP Uromodulin, secreted form

External Links
UniProt P07911
EMBL M15881
M17778
AY162970
AY162963
AY162964
AY162965
AY162967
AY162968
AY162969
AK127643
AK055722
AK091961
AC106796
BC035975
CCDS CCDS10583.1
CCDS61876.1
PIR A30452
RefSeq NP_001008390.1
NP_001265543.1
NP_003352.2
XP_006721149.1
XP_006721150.1
XP_006721151.1
UniGene Hs.654425
ProteinModelPortal P07911
SMR P07911
BioGrid 113216
IntAct P07911
STRING 9606.ENSP00000306279
UniCarbKB P07911
DMDM 137116
PaxDb P07911
PRIDE P07911
Ensembl ENST00000302509
ENST00000396134
ENST00000570689
GeneID 7369
KEGG hsa:7369
UCSC uc002dgz.3
CTD 7369
GeneCards GC16M020344
GeneReviews UMOD
H-InvDB HIX0012858
HGNC HGNC:12559
HPA CAB009446
HPA043420
HPA054721
MIM 162000
191845
603860
609886
neXtProt NX_P07911
Orphanet 34149
209886
PharmGKB PA37199
eggNOG NOG44010
GeneTree ENSGT00530000063244
HOGENOM HOG000293303
HOVERGEN HBG004349
InParanoid P07911
KO K18274
OrthoDB EOG7SFHWJ
PhylomeDB P07911
TreeFam TF330284
GeneWiki Tamm%E2%80%93Horsfall_protein
GenomeRNAi 7369
NextBio 28856
PRO PR:P07911
Proteomes UP000005640
Bgee P07911
CleanEx HS_UMOD
ExpressionAtlas P07911
Genevestigator P07911
GO GO:0031225
GO:0016324
GO:0016323
GO:0060170
GO:0031410
GO:0005615
GO:0070062
GO:0019898
GO:0005794
GO:0045121
GO:0072372
GO:0000922
GO:0005509
GO:0019864
GO:0006968
GO:0048878
GO:0007588
GO:0007157
GO:0007159
GO:0072218
GO:0072221
GO:0072233
GO:0008285
GO:1990266
GO:2000021
GO:0010033
Gene3D 2.40.155.10
InterPro IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR024731
IPR023413
IPR009030
IPR001507
IPR017977
Pfam PF12947
PF07645
PF00100
PRINTS PR00023
SMART SM00181
SM00179
SM00241
SUPFAM SSF57184
PROSITE PS00010
PS01186
PS50026
PS01187
PS00682
PS51034

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1990266

neutrophil migration

PMID:20798515[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019864

IgG binding

PMID:20798515[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:20798515[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:20798515[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007159

leukocyte cell-cell adhesion

PMID:20798515[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:20798515[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:20172860[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031225

anchored component of membrane

PMID:2249987[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:7028707[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:7028707[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:20172860[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:18025791[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072233

metanephric thick ascending limb development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X17
ensembl:ENSMUSP00000033263

P

Seeded From UniProt

complete

involved_in

GO:0072221

metanephric distal convoluted tubule development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X17
ensembl:ENSMUSP00000033263

P

Seeded From UniProt

complete

involved_in

GO:0072218

metanephric ascending thin limb development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X17
ensembl:ENSMUSP00000033263

P

Seeded From UniProt

complete

involved_in

GO:0050801

ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X17
ensembl:ENSMUSP00000033263

P

Seeded From UniProt

complete

involved_in

GO:0048878

chemical homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X17
ensembl:ENSMUSP00000033263

P

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X17
ensembl:ENSMUSP00000033263

C

Seeded From UniProt

complete

involved_in

GO:0007588

excretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X17
ensembl:ENSMUSP00000033263

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

part_of

GO:0019898

extrinsic component of membrane

PMID:7873609[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:2409603[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006968

cellular defense response

PMID:2409603[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-8855954

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969

C

Seeded From UniProt

complete

part_of

GO:0031225

anchored component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0336

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0060170

ciliary membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0305

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0026

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0015

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Schmid, M et al. (2010) Uromodulin facilitates neutrophil migration across renal epithelial monolayers. Cell. Physiol. Biochem. 26 311-8 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ 4.0 4.1 Zaucke, F et al. (2010) Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression. Hum. Mol. Genet. 19 1985-97 PubMed GONUTS page
  5. ↑ Rindler, MJ et al. (1990) Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is a phosphatidylinositol-linked membrane protein. J. Biol. Chem. 265 20784-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 Sikri, KL et al. (1981) Localization of Tamm-Horsfall glycoprotein in the human kidney using immuno-fluorescence and immuno-electron microscopical techniques. J. Anat. 132 597-605 PubMed GONUTS page
  7. ↑ Trzpis, M et al. (2007) Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys. Nephron Exp. Nephrol. 107 e119-31 PubMed GONUTS page
  8. ↑ Prasadan, K et al. (1995) Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine. Biochim. Biophys. Acta 1260 328-32 PubMed GONUTS page
  9. ↑ 9.0 9.1 Muchmore, AV & Decker, JM (1985) Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women. Science 229 479-81 PubMed GONUTS page
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